For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
5
views
Article has an altmetric score of 2
194
references
 Top references
cited by
2
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      314
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      DHCR24 in Tumor Diagnosis and Treatment: A Comprehensive Review

      review-article
      Author(s): , MD 1 , 2 , 3 , 4 , , MS 2 , 3 , 4 , 5 ,
      Publication date (Electronic):
      Journal: Technology in Cancer Research & Treatment
      Publisher: SAGE Publications
      Keywords: DHCR24, cholesterol, ROS, tumor, apoptosis

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          As an important nutrient in the human body, cholesterol can not only provide structural components for the body's cells, but also can be transformed into a variety of active substances to regulate cell signaling pathways. As an important cholesterol synthase, DHCR24 participates in important regulatory processes in the body. The application of DHCR24 in tumor clinical diagnosis and treatment also attracts much attention. This article reviews the structure and regulatory characteristics of DHCR24, and the research of DHCR24 on tumor progression. We summarize the possible mechanisms of DHCR24 promoting tumor progression through reactive oxygen species (ROS), p53, Ras and PI3K-AKT pathways. Through our review, we hope to provide more research ideas and reference value for the application of DHCR24 in tumor prevention and treatment.

          Related collections

          Most cited references194

          • Record: found
          • Abstract: found
          • Article: not found

          Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

          Hyuna Sung, Jacques Ferlay, Rebecca Siegel … (2021)
          This article provides an update on the global cancer burden using the GLOBOCAN 2020 estimates of cancer incidence and mortality produced by the International Agency for Research on Cancer. Worldwide, an estimated 19.3 million new cancer cases (18.1 million excluding nonmelanoma skin cancer) and almost 10.0 million cancer deaths (9.9 million excluding nonmelanoma skin cancer) occurred in 2020. Female breast cancer has surpassed lung cancer as the most commonly diagnosed cancer, with an estimated 2.3 million new cases (11.7%), followed by lung (11.4%), colorectal (10.0 %), prostate (7.3%), and stomach (5.6%) cancers. Lung cancer remained the leading cause of cancer death, with an estimated 1.8 million deaths (18%), followed by colorectal (9.4%), liver (8.3%), stomach (7.7%), and female breast (6.9%) cancers. Overall incidence was from 2-fold to 3-fold higher in transitioned versus transitioning countries for both sexes, whereas mortality varied <2-fold for men and little for women. Death rates for female breast and cervical cancers, however, were considerably higher in transitioning versus transitioned countries (15.0 vs 12.8 per 100,000 and 12.4 vs 5.2 per 100,000, respectively). The global cancer burden is expected to be 28.4 million cases in 2040, a 47% rise from 2020, with a larger increase in transitioning (64% to 95%) versus transitioned (32% to 56%) countries due to demographic changes, although this may be further exacerbated by increasing risk factors associated with globalization and a growing economy. Efforts to build a sustainable infrastructure for the dissemination of cancer prevention measures and provision of cancer care in transitioning countries is critical for global cancer control.
          Article 0 comments Cited 40438 times – based on 0 reviews     Review now
          Article has an altmetric score of 3606
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Mechanisms and regulation of cholesterol homeostasis

            Jie Luo, Hongyuan Yang, Bao-Liang Song (2019)
            Cholesterol homeostasis is vital for proper cellular and systemic functions. Disturbed cholesterol balance underlies not only cardiovascular disease but also an increasing number of other diseases such as neurodegenerative diseases and cancers. The cellular cholesterol level reflects the dynamic balance between biosynthesis, uptake, export and esterification - a process in which cholesterol is converted to neutral cholesteryl esters either for storage in lipid droplets or for secretion as constituents of lipoproteins. In this Review, we discuss the latest advances regarding how each of the four parts of cholesterol metabolism is executed and regulated. The key factors governing these pathways and the major mechanisms by which they respond to varying sterol levels are described. Finally, we discuss how these pathways function in a concerted manner to maintain cholesterol homeostasis.
            Article 0 comments Cited 608 times – based on 0 reviews     Review now
            Article has an altmetric score of 54
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes.

              Jay Horton, Nila A Shah, Janet A Warrington … (2003)
              The synthesis of fatty acids and cholesterol, the building blocks of membranes, is regulated by three membrane-bound transcription factors: sterol regulatory element-binding proteins (SREBP)-1a, -1c, and -2. Their function in liver has been characterized in transgenic mice that overexpress each SREBP isoform and in mice that lack all three nuclear SREBPs as a result of gene knockout of SREBP cleavage-activating protein (SCAP), a protein required for nuclear localization of SREBPs. Here, we use oligonucleotide arrays hybridized with RNA from livers of three lines of mice (transgenic for SREBP-1a, transgenic for SREBP-2, and knockout for SCAP) to identify genes that are likely to be direct targets of SREBPs in liver. A total of 1,003 genes showed statistically significant increased expression in livers of transgenic SREBP-1a mice, 505 increased in livers of transgenic SREBP-2 mice, and 343 showed decreased expression in Scap-/- livers. A subset of 33 genes met the stringent combinatorial criteria of induction in both SREBP transgenics and decreased expression in SCAP-deficient mice. Of these 33 genes, 13 were previously identified as direct targets of SREBP action. Of the remaining 20 genes, 13 encode enzymes or carrier proteins involved in cholesterol metabolism, 3 participate in fatty acid metabolism, and 4 have no known connection to lipid metabolism. Through application of stringent combinatorial criteria, the transgenic/knockout approach allows identification of genes whose activities are likely to be controlled directly by one family of transcription factors, in this case the SREBPs.
              Article 0 comments Cited 373 times – based on 0 reviews     Review now
              Article has an altmetric score of 19
                Bookmark
                All references

                Author and article information

                Journal
                Journal ID (nlm-ta): Technol Cancer Res Treat
                Journal ID (iso-abbrev): Technol Cancer Res Treat
                Journal ID (publisher-id): TCT
                Journal ID (hwp): sptct
                Title: Technology in Cancer Research & Treatment
                Publisher: SAGE Publications (Sage CA: Los Angeles, CA )
                ISSN (Print): 1533-0346
                ISSN (Electronic): 1533-0338
                Publication date (Electronic): 7 June 2024
                Publication date Collection: 2024
                Volume: 23
                Electronic Location Identifier: 15330338241259780
                Affiliations
                [1 ]Department of Gynecologic Oncology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
                [2 ]National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
                [3 ]Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
                [4 ]Tianjin's Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
                [5 ]Laboratory Animal Center, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
                Author notes
                [*]Zhaosong Wang, Tianjin Medical University Cancer Institute and Hospital, He Xi District, Tianjin, The People's Republic of China. Email: wangzhaosong@ 123456tjmuch.com
                Author information
                https://orcid.org/0000-0003-2217-5138
                Article
                Publisher ID: 10.1177_15330338241259780
                DOI: 10.1177/15330338241259780
                PMC ID: 11162140
                PubMed ID: 38847653
                SO-VID: a0330833-6e46-428a-b647-7eea32cc1708
                Copyright © © The Author(s) 2024
                License:

                This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License ( https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page ( https://us.sagepub.com/en-us/nam/open-access-at-sage).

                History
                Related
                Funding
                Funded by: Seed Foundation of Tianjin Medical University Cancer Institute and Hospital;
                Award ID: #1703
                Categories
                Subject: New insight into targeting biomarkers of solid tumors: Therapy and Mechanism
                Subject: Review
                Custom metadata
                typesetter ts19
                cover-date January-December 2024

                Keywords: dhcr24,cholesterol,ros,tumor,apoptosis
                Data availability:
                Keywords: dhcr24, cholesterol, ros, tumor, apoptosis

                Comments

                Comment on this article

                scite_

                Similar content314

                See all similar

                Cited by2

                See all cited by

                Most referenced authors3,673

                See all reference authors