Intratumor heterogeneity in hepatocellular carcinoma.

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Abstract

Morphologic intratumor heterogeneity is well known to exist in hepatocellular carcinoma (HCC), but very few systematic analyses of this phenomenon have been performed. The aim of this study was to comprehensively characterize morphologic intratumor heterogeneity in HCC. Also, taken into account were well-known immunohistochemical markers and molecular changes in liver cells that are considered in proposed classifications of liver cell neoplasms or discussed as molecular therapeutic targets.

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Journal

Journal ID (iso-abbrev): Clin. Cancer Res.

Title: Clinical cancer research : an official journal of the American Association for Cancer Research

ISSN: 1078-0432

ISSN (Print): 1078-0432

Publication date (Electronic): Apr 15 2015

Volume: 21

Issue: 8

Affiliations

[1 ] Institute of Surgical Pathology, University Hospital Zurich, Zurich, Switzerland. Leibniz Institute for Prevention Research and Epidemiology, BIPS, Bremen, Germany.

[2 ] Institute of Surgical Pathology, University Hospital Zurich, Zurich, Switzerland.

[3 ] Institute of Surgical Pathology, University Hospital Zurich, Zurich, Switzerland. Institute of Virology, Technische Universität München (TUM) and Helmholtz Zentrum München für Gesundheit und Umwelt (HMGU), Germany.

[4 ] Institute of Surgical Pathology, University Hospital Zurich, Zurich, Switzerland. achim.weber@usz.ch.

Article

Publisher Item ID: 1078-0432.CCR-14-0122

DOI: 10.1158/1078-0432.CCR-14-0122

PubMed ID: 25248380

SO-VID: 9f6faa37-c150-4ba2-9675-ca3a149d503e

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