Occurrence and incidence rate of peripheral intravascular catheter-related phlebitis and complications in critically ill patients: a prospective cohort study (AMOR-VENUS study)

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Abstract

Background

The lack of precise information on the epidemiology of peripheral intravascular catheter (PIVC)-related phlebitis and complications in critically ill patients results in the absence of appropriate preventive measures. Therefore, we aimed to describe the epidemiology of the use of PIVCs and the incidence/occurrence of phlebitis and complications in the intensive care unit (ICU).

Methods

This prospective multicenter cohort study was conducted in 23 ICUs in Japan. All consecutive patients aged ≥ 18 years admitted to the ICU were enrolled. PIVCs inserted prior to ICU admission and those newly inserted after ICU admission were included in the analysis. Characteristics of the ICU, patients, and PIVCs were recorded. The primary and secondary outcomes were the occurrence and incidence rate of PIVC-related phlebitis and complications (catheter-related blood stream infection [CRBSI] and catheter failure) during the ICU stay.

Results

We included 2741 patients and 7118 PIVCs, of which 48.2% were inserted in the ICU. PIVC-related phlebitis occurred in 7.5% (95% confidence interval [CI] 6.9–8.2%) of catheters (3.3 cases / 100 catheter-days) and 12.9% (95% CI 11.7–14.2%) of patients (6.3 cases / 100 catheter-days). Most PIVCs were removed immediately after diagnosis of phlebitis (71.9%). Grade 1 was the most common phlebitis (72.6%), while grade 4 was the least common (1.5%). The incidence rate of CRBSI was 0.8% (95% CI 0.4–1.2%). In cases of catheter failure, the proportion and incidence rate per 100 intravenous catheter-days of catheter failure were 21% (95% CI 20.0-21.9%) and 9.1 (95% CI 8.7–10.0), respectively.

Conclusion

PIVC-related phlebitis and complications were common in critically ill patients. The results suggest the importance of preventing PIVC-related complications, even in critically ill patients.

Trial registration

UMIN-CTR, the Japanese clinical trial registry (registration number: UMIN000028019, July 1, 2017).

Supplementary Information

The online version contains supplementary material available at 10.1186/s40560-020-00518-4.

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Most cited references 39

Record: found
Abstract: found
Article: not found

A new method of classifying prognostic comorbidity in longitudinal studies: Development and validation

Mary Charlson, Peter Pompei, Kathy Ales … (1987)

The objective of this study was to develop a prospectively applicable method for classifying comorbid conditions which might alter the risk of mortality for use in longitudinal studies. A weighted index that takes into account the number and the seriousness of comorbid disease was developed in a cohort of 559 medical patients. The 1-yr mortality rates for the different scores were: "0", 12% (181); "1-2", 26% (225); "3-4", 52% (71); and "greater than or equal to 5", 85% (82). The index was tested for its ability to predict risk of death from comorbid disease in the second cohort of 685 patients during a 10-yr follow-up. The percent of patients who died of comorbid disease for the different scores were: "0", 8% (588); "1", 25% (54); "2", 48% (25); "greater than or equal to 3", 59% (18). With each increased level of the comorbidity index, there were stepwise increases in the cumulative mortality attributable to comorbid disease (log rank chi 2 = 165; p less than 0.0001). In this longer follow-up, age was also a predictor of mortality (p less than 0.001). The new index performed similarly to a previous system devised by Kaplan and Feinstein. The method of classifying comorbidity provides a simple, readily applicable and valid method of estimating risk of death from comorbid disease for use in longitudinal studies. Further work in larger populations is still required to refine the approach because the number of patients with any given condition in this study was relatively small.

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Record: found
Abstract: found
Article: not found

A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study.

J R Le Gall, S Lemeshow, F Saulnier (1993)

To develop and validate a new Simplified Acute Physiology Score, the SAPS II, from a large sample of surgical and medical patients, and to provide a method to convert the score to a probability of hospital mortality. The SAPS II and the probability of hospital mortality were developed and validated using data from consecutive admissions to 137 adult medical and/or surgical intensive care units in 12 countries. The 13,152 patients were randomly divided into developmental (65%) and validation (35%) samples. Patients younger than 18 years, burn patients, coronary care patients, and cardiac surgery patients were excluded. Vital status at hospital discharge. The SAPS II includes only 17 variables: 12 physiology variables, age, type of admission (scheduled surgical, unscheduled surgical, or medical), and three underlying disease variables (acquired immunodeficiency syndrome, metastatic cancer, and hematologic malignancy). Goodness-of-fit tests indicated that the model performed well in the developmental sample and validated well in an independent sample of patients (P = .883 and P = .104 in the developmental and validation samples, respectively). The area under the receiver operating characteristic curve was 0.88 in the developmental sample and 0.86 in the validation sample. The SAPS II, based on a large international sample of patients, provides an estimate of the risk of death without having to specify a primary diagnosis. This is a starting point for future evaluation of the efficiency of intensive care units.

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Record: found
Abstract: not found
Article: not found

The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine.

J. Vincent, R. Moreno, J Takala … (1996)

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Author and article information

Contributors

Hideto Yasuda:

ORCID: http://orcid.org/0000-0003-3153-1595

yasudahideto@me.com

: hyasuda1021@gmail.com

Journal

Journal ID (nlm-ta): J Intensive Care

Journal ID (iso-abbrev): J Intensive Care

Title: Journal of Intensive Care

Publisher: BioMed Central (London )

ISSN (Electronic): 2052-0492

Publication date (Electronic): 6 January 2021

Publication date PMC-release: 6 January 2021

Publication date Collection: 2021

Volume: 9

Electronic Location Identifier: 3

Affiliations

[1 ]GRID grid.410804.9, ISNI 0000000123090000, Department of Emergency and Critical Care Medicine, , Jichi Medical University Saimata Medical Center, ; 1-847, Amanuma-cho, Oomiya-ku, Saitama-shi, Saitama, 330-8503 Japan

[2 ]GRID grid.412096.8, ISNI 0000 0001 0633 2119, Department of Clinical Research Education and Training Unit, , Keio University Hospital Clinical and Translational Research Center (CTR), ; Tokyo, Japan

[3 ]GRID grid.26091.3c, ISNI 0000 0004 1936 9959, Department of Preventive Medicine and Public Health, , Keio University School of Medicine, ; Tokyo, Japan

[4 ]GRID grid.414927.d, ISNI 0000 0004 0378 2140, Department of Intensive Care Medicine, , Kameda Medical Center, ; Chiba, Japan

[5 ]GRID grid.414936.d, ISNI 0000 0004 0418 6412, Department of Critical Care Medicine, , Japanese Red Cross Society Wakayama Medical Center, ; Wakayama, Japan

[6 ]GRID grid.410775.0, ISNI 0000 0004 1762 2623, Emergency and Critical Care Medicine, , Japanese Red Cross Musashino Hospital, ; Tokyo, Japan

[7 ]GRID grid.414927.d, ISNI 0000 0004 0378 2140, Department of Medical Engineer, , Kameda Medical Center, ; Chiba, Japan

[8 ]GRID grid.257022.0, ISNI 0000 0000 8711 3200, Department of Emergency and Critical Care Medicine, Graduate School of Biomedical and Health Sciences, , Hiroshima University, ; Hiroshima, Japan

[9 ]GRID grid.413006.0, Division of Clinical Laboratory and Infection Control, , Yamagata University Hospital, ; Yamagata, Japan

[10 ]GRID grid.26091.3c, ISNI 0000 0004 1936 9959, Biostatistics, Clinical and Translational Research Center, , Keio University School of Medicine, ; Tokyo, Japan

[11 ]GRID grid.268441.d, ISNI 0000 0001 1033 6139, Faculty of Data Science, , Yokohama City University School of Data Science, ; Yokohama, Japan

[12 ]GRID grid.412764.2, ISNI 0000 0004 0372 3116, Department of Pharmacy, , St. Marianna University Hospital, ; Kanagawa, Japan

[13 ]GRID grid.412757.2, ISNI 0000 0004 0641 778X, Intensive Care Unit, , Tohoku University Hospital, ; Miyagi, Japan

[14 ]GRID grid.415020.2, ISNI 0000 0004 0467 0255, Department of Anesthesiology and Critical Care Medicine, , Jichi Medical University Saitama Medical Center, ; Saitama, Japan

[15 ]GRID grid.416814.e, ISNI 0000 0004 1772 5040, Department of Emergency and Critical Care Medicine, , Okayama Saiseikai General Hospital, ; Okayama, Japan

[16 ]GRID grid.415980.1, ISNI 0000 0004 1764 753X, Intensive Care Unit, , Mitsui Memorial Hospital, ; Tokyo, Japan

[17 ]GRID grid.411731.1, ISNI 0000 0004 0531 3030, Department of Anesthesiology and Intensive Care Medicine, , International University of Health and Welfare, School of Medicine, ; Chiba, Japan

[18 ]Intensive Care Unit, Sakai city medical center, Osaka, Japan

[19 ]Emergency And Critical Care Medicine, Nerima Hikarigaoka Hospital, Tokyo, Japan

[20 ]GRID grid.416684.9, ISNI 0000 0004 0378 7419, Division of Critical Care Medicine, , Saiseikai Utsunomiya Hospital, ; Tochigi, Japan

[21 ]GRID grid.414159.c, ISNI 0000 0004 0378 1009, Department of Emergency and Intensive Care Medicine, , JA Hiroshima General Hospital, ; Hiroshima, Japan

[22 ]GRID grid.411873.8, ISNI 0000 0004 0616 1585, Division of Intensive Care Unit, , Nagasaki University Hospital, ; Nagasaki, Japan

[23 ]GRID grid.471800.a, Emergency Medical Center, , Kagawa University Hospital, ; Kagawa, Japan

[24 ]GRID grid.415604.2, ISNI 0000 0004 1763 8262, Division of Emergency Medicine, , Japanese Red Cross Kyoto Daiichi Hospital, ; Kyoto, Japan

[25 ]GRID grid.416827.e, ISNI 0000 0000 9413 4421, Intensive Care Unit, , Okinawa Chubu Hospital, ; Okinawa, Japan

[26 ]GRID grid.413006.0, Critical Care Center, , Yamagata University Hospital, ; Yamagata, Japan

[27 ]GRID grid.415887.7, ISNI 0000 0004 1769 1768, Intensive Care Unit, , Kochi Medical School Hospital, ; Kochi, Japan

[28 ]Intensive Care Unit, Shiroyama Hospital, Osaka, Japan

[29 ]GRID grid.416612.6, ISNI 0000 0004 1774 5826, Department of Acute Care and General Medicine, , Saiseikai Kumamoto Hospital, ; Kumamoto, Japan

[30 ]GRID grid.256115.4, ISNI 0000 0004 1761 798X, Emergency Intensive Care Unit, , Fujita Health University, ; Nagoya, Japan

Author information

Hideto Yasuda http://orcid.org/0000-0003-3153-1595

Article

Publisher ID: 518

DOI: 10.1186/s40560-020-00518-4

PMC ID: 7789473

PubMed ID: 33407891

SO-VID: 9ee5b25a-21b5-4213-9846-58fc33e50f62

License:

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

History

Date received : 23 October 2020

Date accepted : 23 December 2020

Funding

Funded by: Grants-in-Aid for Scientific Research, Japan Society For The Promotion Of Science

Award ID: 17K15870

Award Recipient : Hideto Yasuda

Custom metadata

Keywords: catheter,catheter-related infections,critically ill patient,epidemiology,intensive care unit,phlebitis

Data availability:

Keywords: catheter, catheter-related infections, critically ill patient, epidemiology, intensive care unit, phlebitis

Occurrence and incidence rate of peripheral intravascular catheter-related phlebitis and complications in critically ill patients: a prospective cohort study (AMOR-VENUS study)

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Abstract

Background

Methods

Results

Conclusion

Trial registration

Supplementary Information

Related collections

Pediatric Pulse: Advancing Neonatal and Child Health

Most cited references 39

A new method of classifying prognostic comorbidity in longitudinal studies: Development and validation

A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study.

The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine.

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