For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
0
views
32
references
 Top references
cited by
0
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      512
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Postoperative C-reactive protein levels correlate with reduced spinal column mobility after median sternotomy: a prospective cohort study

      research-article

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Background

          The sternum is connected to the spinal column via the ribs, forming the thorax. Therefore, it is necessary to consider the effect of a midline sternotomy on the spinal column, but no in vivo studies have been conducted to date. We investigated the changes in the range of motion of the spinal column before and after midline sternotomy and the perioperative factors that have the greatest influence.

          Methods

          The participants were patients who had undergone cardiac surgery through a standby midline sternotomy. Spinal range of motion in forward flexion was measured before and after surgery. The following perioperative factors were investigated: operating time, days to postoperative measurement, C-reactive protein (CRP) measurement on the third postoperative day, the day of the start of bed release, and the stage of bed release progression on the second postoperative day. Statistics were compared between the two groups before and after surgery for each factor. Multiple regression analysis (forced entry method) was then performed with the change in spinal range of motion, which showed statistical differences between the preoperative and postoperative groups, as the dependent variable and each perioperative factor as the independent variable.

          Results

          The study included 93 patients. Postoperatively, there was a significant decrease in thoracic spine range of motion. Multiple regression analysis showed that an increase in CRP on the third postoperative day was responsible for the decrease in thoracic range of motion (β=−0.30, P<0.01).

          Conclusions

          After median sternotomy, thoracic spine range of motion was decreased and correlated with postoperative inflammation.

          Related collections

          Most cited references32

          • Record: found
          • Abstract: found
          • Article: found
          Is Open Access

          Keloid and Hypertrophic Scars Are the Result of Chronic Inflammation in the Reticular Dermis

          Rei Ogawa (2017)
          Keloids and hypertrophic scars are caused by cutaneous injury and irritation, including trauma, insect bite, burn, surgery, vaccination, skin piercing, acne, folliculitis, chicken pox, and herpes zoster infection. Notably, superficial injuries that do not reach the reticular dermis never cause keloidal and hypertrophic scarring. This suggests that these pathological scars are due to injury to this skin layer and the subsequent aberrant wound healing therein. The latter is characterized by continuous and histologically localized inflammation. As a result, the reticular layer of keloids and hypertrophic scars contains inflammatory cells, increased numbers of fibroblasts, newly formed blood vessels, and collagen deposits. Moreover, proinflammatory factors, such as interleukin (IL)-1α, IL-1β, IL-6, and tumor necrosis factor-α are upregulated in keloid tissues, which suggests that, in patients with keloids, proinflammatory genes in the skin are sensitive to trauma. This may promote chronic inflammation, which in turn may cause the invasive growth of keloids. In addition, the upregulation of proinflammatory factors in pathological scars suggests that, rather than being skin tumors, keloids and hypertrophic scars are inflammatory disorders of skin, specifically inflammatory disorders of the reticular dermis. Various external and internal post-wounding stimuli may promote reticular inflammation. The nature of these stimuli most likely shapes the characteristics, quantity, and course of keloids and hypertrophic scars. Specifically, it is likely that the intensity, frequency, and duration of these stimuli determine how quickly the scars appear, the direction and speed of growth, and the intensity of symptoms. These proinflammatory stimuli include a variety of local, systemic, and genetic factors. These observations together suggest that the clinical differences between keloids and hypertrophic scars merely reflect differences in the intensity, frequency, and duration of the inflammation of the reticular dermis. At present, physicians cannot (or at least find it very difficult to) control systemic and genetic risk factors of keloids and hypertrophic scars. However, they can use a number of treatment modalities that all, interestingly, act by reducing inflammation. They include corticosteroid injection/tape/ointment, radiotherapy, cryotherapy, compression therapy, stabilization therapy, 5-fluorouracil (5-FU) therapy, and surgical methods that reduce skin tension.
          Article 0 comments Cited 271 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            A new skin-surface device for measuring the curvature and global and segmental ranges of motion of the spine: reliability of measurements and comparison with data reviewed from the literature.

            G Balaban, Jiří Dvořák, Anne F Mannion … (2004)
            There is an increasing awareness of the risks and dangers of exposure to radiation associated with repeated radiographic assessment of spinal curvature and spinal movements. As such, attempts are continuously being made to develop skin-surface devices for use in examining the progression and response to treatment of various spinal disorders. However, the reliability and validity of measurements recorded with such devices must be established before they can be recommended for use in the research or clinical environment. The aim of this study was to examine the reliability of measurements using a newly developed skin-surface device, the Spinal Mouse. Twenty healthy volunteers (mean age 41 +/- 12 years, nine males, 11 females) took part. On 2 separate days, spinal curvature was measured with the Spinal Mouse during standing, full flexion, and full extension (each three times by each of two examiners). Paired t-tests, intraclass correlation coefficients (ICC), and standard errors of measurement (SEM) with 95% confidence intervals were used to characterise between-day and interexaminer reliability for: standing sacral angle, lumbar lordosis, thoracic kyphosis, and ranges of motion (flexion, extension) of the thoracic spine, lumbar spine, hips, and trunk. The between-day reliability for segmental ranges of flexion was also determined for each motion segment from T1-2 to L5-S1. The majority of parameters measured for the 'global regions' (thoracic, lumbar, or hips) showed good between-day reliability. Depending on the parameter of interest, between-day ICCs ranged from 0.67 to 0.92 for examiner 1 (average 0.82) and 0.57 to 0.95 for examiner 2 (average 0.83); for 70% of the parameters measured, the ICCs were greater than 0.8 and generally highest for the lumbar spine and whole trunk measures. For lumbar spine range of flexion, the SEM was approximately 3 degrees. The ICCs were also good for the interexaminer comparisons, ranging from 0.62 to 0.93 on day 1 (average 0.81) and 0.70 to 0.94 on day 2 (average 0.86), although small systematic differences were sometimes observed in their mean values. The latter were still evident even if both examiners used the same skin markings. For segmental ranges of flexion, the ICCs varied between vertebral levels but overall were lower than for the global measures (average for all levels in all analyses, ICC 0.6). For each examiner, the average between-day SEM over all vertebral levels was approximately 2 degrees. For 'global' regions of the spine, the Spinal Mouse delivered consistently reliable values for standing curvatures and ranges of motion which compared well with those reported in the literature. This suggests that the device can be reliably implemented for in vivo studies of the sagittal profile and range of motion of the spine. As might be expected for the smaller angles being measured, the segmental ranges of flexion showed lower reliability. Their usefulness with regard to the interpretation of individual results and the detection of 'real change' on an individual basis thus remains questionable. Nonetheless, the group mean values showed few between-day differences, suggesting that the device may still be of use in providing clinically interesting data on segmental motion when examining groups of individuals with a given spinal pathology or undergoing some type of intervention.
            Article 0 comments Cited 73 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Thoracic kyphosis, rib mobility, and lung volumes in normal women and women with osteoporosis.

              D E Culham, Ricardo H Flores Jiménez, Christine E. King (1994)
              Lung volumes and rib mobility were measured in 15 women with kyphosis resulting from spinal osteoporosis and in 15 healthy women. The study first sought to determine the relationship between thoracic kyphosis and rib mobility and then sought to determine the effect of kyphosis and associated changes in rib mobility on respiratory function. Spinal deformity in ankylosing spondylitis and scoliosis is associated with alterations in respiratory function. The effect of thoracic kyphosis on respiratory mechanics has not been investigated in an osteoporotic population. Lung volumes were measured using a spirometer, and rib mobility, during maximal inspiratory and expiratory maneuvers, was monitored with four motion sensors placed anteriorly, posteriorly, and laterally on the thorax. Vital capacity, inspiratory capacity, total lung capacity, and lateral expansion of the thorax were lower in the osteoporotic group (P < 0.05). There was a significant negative correlation between kyphosis angle and inspiratory capacity, vital capacity, and lateral expansion of the thorax. Lung volumes and rib mobility were significantly impaired in women with thoracic kyphosis.
              Article 0 comments Cited 36 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Journal
                Journal ID (nlm-ta): J Thorac Dis
                Journal ID (iso-abbrev): J Thorac Dis
                Journal ID (publisher-id): JTD
                Title: Journal of Thoracic Disease
                Publisher: AME Publishing Company
                ISSN (Print): 2072-1439
                ISSN (Electronic): 2077-6624
                Publication date (Electronic): 12 January 2024
                Publication date (Print): 30 January 2024
                Volume: 16
                Issue: 1
                Pages: 469-478
                Affiliations
                [1 ]deptDepartment of Physical Therapy, School of Health Science , International University of Health and Welfare , Tochigi, Japan;
                [2 ]deptDepartments of Physical Therapy, of Rehabilitation , International University of Health and Welfare Hospital , Tochigi, Japan
                Author notes

                Contributions: (I) Conception and design: A Ito; (II) Administrative support: All authors; (III) Provision of study materials or patients: A Ito, H Irie; (IV) Collection and assembly of data: A Ito, H Irie; (V) Data analysis and interpretation: A Ito, T Hara; (VI) Manuscript writing: All authors; (VII) Final approval of manuscript: All authors.

                Correspondence to: Akihiro Ito, RPT, PhD. Department of Physical Therapy, School of Health Science, International University of Health and Welfare, 2600-1 Kitakanemaru, Otawara-shi, Tochigi 324-8501, Japan; Departments of Physical Therapy, of Rehabilitation, International University of Health and Welfare Hospital, 537-3 Iguchi, Nasushiobara-shi, Tochigi 329-2763, Japan. Email: i.akihiro@ 123456iuhw.ac.jp .
                [^]

                ORCID: 0000-0003-2139-3985.

                Article
                Publisher ID: jtd-16-01-469
                DOI: 10.21037/jtd-23-1439
                PMC ID: 10894417
                PubMed ID: 38410601
                SO-VID: 9eb236a7-6810-412d-9b1f-61b7e4749323
                Copyright © 2024 Journal of Thoracic Disease. All rights reserved.
                License:

                Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

                History
                Date received : 13 September 2023
                Date accepted : 08 December 2023
                Funding
                Funded by: Grant-in-Aid for Scientific Research
                Award ID: JSPS KAKENHI grant No. 19K19842
                Categories
                Subject: Original Article

                Keywords: median sternotomy,spine,perioperative,c-reactive protein (crp),multiple regression analysis
                Data availability:
                Keywords: median sternotomy, spine, perioperative, c-reactive protein (crp), multiple regression analysis

                Comments

                Comment on this article