Silencing of tuberin enhances photoreceptor survival and function in a preclinical model of retinitis pigmentosa (an american ophthalmological society thesis).

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Abstract

To assess the functional consequences of silencing of tuberin, an inhibitor of the mTOR signaling pathway, in a preclinical model of retinitis pigmentosa (RP) in order to test the hypothesis that insufficient induction of the protein kinase B (PKB)-regulated tuberin/mTOR self-survival pathway initiates apoptosis.

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Journal

Journal ID (iso-abbrev): Trans Am Ophthalmol Soc

Title: Transactions of the American Ophthalmological Society

ISSN (Electronic): 1545-6110

ISSN (Print): 0065-9533

Publication date (Electronic): Jul 2014

Volume: 112

Affiliations

[1 ] Institute of Human Nutrition, Department of Pathology and Cell Biology and the Department of Ophthalmology, Columbia University, New York, New York.

[2 ] Department of Ophthalmology, Columbia University, New York, New York.

[3 ] Department of Ophthalmology, Columbia University, New York, New York; and Tianjin Medical University Eye Hospital, Tianjin, China.

[4 ] Department of Ophthalmology, Columbia University, New York, New York; and Kresge Eye Institute, Wayne State University, Detroit, Michigan.

[5 ] Department of Ophthalmology, Columbia University, New York, New York; and Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, Massachusetts.

[6 ] Department of Ophthalmology, Columbia University, New York, New York; and Neural Stem Cell Institute, Rensselaer, New York.

[7 ] Omics Lab, Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, Iowa.

Article

PMC ID: 4311672

PubMed ID: 25646031

SO-VID: 9e8221f0-3d56-4367-a2e1-2ea8d4ad8a99

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