Potential Anticancer Properties of Osthol: A Comprehensive Mechanistic Review

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Abstract

Cancer is caused by uncontrolled cell proliferation which has the potential to occur in different tissues and spread into surrounding and distant tissues. Despite the current advances in the field of anticancer agents, rapidly developing resistance against different chemotherapeutic drugs and significantly higher off-target effects cause millions of deaths every year. Osthol is a natural coumarin isolated from Apiaceaous plants which has demonstrated several pharmacological effects, such as antineoplastic, anti-inflammatory and antioxidant properties. We have attempted to summarize up-to-date information related to pharmacological effects and molecular mechanisms of osthol as a lead compound in managing malignancies. Electronic databases, including PubMed, Cochrane library, ScienceDirect and Scopus were searched for in vitro, in vivo and clinical studies on anticancer effects of osthol. Osthol exerts remarkable anticancer properties by suppressing cancer cell growth and induction of apoptosis. Osthol’s protective and therapeutic effects have been observed in different cancers, including ovarian, cervical, colon and prostate cancers as well as chronic myeloid leukemia, lung adenocarcinoma, glioma, hepatocellular, glioblastoma, renal and invasive mammary carcinoma. A large body of evidence demonstrates that osthol regulates apoptosis, proliferation and invasion in different types of malignant cells which are mediated by multiple signal transduction cascades. In this review, we set spotlights on various pathways which are targeted by osthol in different cancers to inhibit cancer development and progression.

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Cancer Statistics, 2008

A. Jemal, R. Siegel, E. Ward … (2008)

Each year, the American Cancer Society estimates the number of new cancer cases and deaths expected in the United States in the current year and compiles the most recent data on cancer incidence, mortality, and survival based on incidence data from the National Cancer Institute, Centers for Disease Control and Prevention, and the North American Association of Central Cancer Registries and mortality data from the National Center for Health Statistics. Incidence and death rates are age-standardized to the 2000 US standard million population. A total of 1,437,180 new cancer cases and 565,650 deaths from cancer are projected to occur in the United States in 2008. Notable trends in cancer incidence and mortality include stabilization of incidence rates for all cancer sites combined in men from 1995 through 2004 and in women from 1999 through 2004 and a continued decrease in the cancer death rate since 1990 in men and since 1991 in women. Overall cancer death rates in 2004 compared with 1990 in men and 1991 in women decreased by 18.4% and 10.5%, respectively, resulting in the avoidance of over a half million deaths from cancer during this time interval. This report also examines cancer incidence, mortality, and survival by site, sex, race/ethnicity, education, geographic area, and calendar year, as well as the proportionate contribution of selected sites to the overall trends. Although much progress has been made in reducing mortality rates, stabilizing incidence rates, and improving survival, cancer still accounts for more deaths than heart disease in persons under age 85 years. Further progress can be accelerated by supporting new discoveries and by applying existing cancer control knowledge across all segments of the population.

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Curcumin: A review of anti-cancer properties and therapeutic activity in head and neck squamous cell carcinoma

Reason Wilken, Mysore Veena, Marilene B Wang … (2011)

Curcumin (diferuloylmethane) is a polyphenol derived from the Curcuma longa plant, commonly known as turmeric. Curcumin has been used extensively in Ayurvedic medicine for centuries, as it is nontoxic and has a variety of therapeutic properties including anti-oxidant, analgesic, anti-inflammatory and antiseptic activity. More recently curcumin has been found to possess anti-cancer activities via its effect on a variety of biological pathways involved in mutagenesis, oncogene expression, cell cycle regulation, apoptosis, tumorigenesis and metastasis. Curcumin has shown anti-proliferative effect in multiple cancers, and is an inhibitor of the transcription factor NF-κB and downstream gene products (including c-myc, Bcl-2, COX-2, NOS, Cyclin D1, TNF-α, interleukins and MMP-9). In addition, curcumin affects a variety of growth factor receptors and cell adhesion molecules involved in tumor growth, angiogenesis and metastasis. Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide and treatment protocols include disfiguring surgery, platinum-based chemotherapy and radiation, all of which may result in tremendous patient morbidity. As a result, there is significant interest in developing adjuvant chemotherapies to augment currently available treatment protocols, which may allow decreased side effects and toxicity without compromising therapeutic efficacy. Curcumin is one such potential candidate, and this review presents an overview of the current in vitro and in vivo data supporting its therapeutic activity in head and neck cancer as well as some of the challenges concerning its development as an adjuvant chemotherapeutic agent.

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Review on Natural Coumarin Lead Compounds for Their Pharmacological Activity

K. Venugopala, K. Rashmi, B. Odhav (2013)

Coumarin (2H-1-benzopyran-2-one) is a plant-derived natural product known for its pharmacological properties such as anti-inflammatory, anticoagulant, antibacterial, antifungal, antiviral, anticancer, antihypertensive, antitubercular, anticonvulsant, antiadipogenic, antihyperglycemic, antioxidant, and neuroprotective properties. Dietary exposure to benzopyrones is significant as these compounds are found in vegetables, fruits, seeds, nuts, coffee, tea, and wine. In view of the established low toxicity, relative cheapness, presence in the diet, and occurrence in various herbal remedies of coumarins, it appears prudent to evaluate their properties and applications further.

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Journal ID (nlm-ta): Nutrients

Journal ID (iso-abbrev): Nutrients

Journal ID (publisher-id): nutrients

Title: Nutrients

Publisher: MDPI

ISSN (Electronic): 2072-6643

Publication date (Electronic): 03 January 2018

Publication date Collection: January 2018

Volume: 10

Issue: 1

Electronic Location Identifier: 36

Affiliations

[1 ]Pharmaceutical Sciences Research Center, School of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah 67146, Iran; yshokoohinia@ 123456kums.ac.ir (Y.S.); fataneh.jafari@ 123456yahoo.com (F.J.); lhosseinzadeh90@ 123456yahoo.com (L.H.)

[2 ]Department of Pharmacognosy and Biotechnology, School of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah 67146, Iran

[3 ]Students Research Committee, School of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah 67146, Iran; zeynabmohamadi47@ 123456yahoo.com (Z.M.); leilibazvandi@ 123456yahoo.com (L.B.)

[4 ]Department of Clinical and Administrative Sciences, College of Pharmacy, Larkin University, Miami, FL 33169, USA; NChow@ 123456ularkin.org

[5 ]School of Health Sciences, University of Turabo, Gurabo 00778, Puerto Rico; pbhattacharyya@ 123456suagm.edu

[6 ]Laboratory for Translational Oncology and Personalized Medicine, Rashid Latif Medical College, Lahore 54000, Pakistan; ammadfarooqi@ 123456rlmclahore.com

[7 ]Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran 1435916471, Iran; Nabavi208@ 123456gmail.com

[8 ]Department of Pharmacology, Faculty of Pharmacy, University of Erciyes, 38039 Kayseri, Turkey; eczbetul@ 123456yahoo.com

[9 ]Department of Pharmaceutical Sciences, College of Pharmacy, Larkin University, Miami, FL 33169, USA

Author notes

[* ]Correspondence: mh.farzaei@ 123456gmail.com (M.H.F.); abishayee@ 123456ularkin.org or abishayee@ 123456gmail.com (A.B.) Tel.: +98-831-427-6493 (M.H.F.); +1-305-760-7511 (A.B.)

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Mükerrem Betül Yerer https://orcid.org/0000-0002-4503-8032

Article

Publisher ID: nutrients-10-00036

DOI: 10.3390/nu10010036

PMC ID: 5793264

PubMed ID: 29301373

SO-VID: 9e2ea522-d7d6-4680-b6e6-764f73c92e29

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Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/).

Potential Anticancer Properties of Osthol: A Comprehensive Mechanistic Review

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Hogrefe Medicine

Most cited references 80

Cancer Statistics, 2008

Curcumin: A review of anti-cancer properties and therapeutic activity in head and neck squamous cell carcinoma

Review on Natural Coumarin Lead Compounds for Their Pharmacological Activity

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