Article Information
Corresponding Author: Emmanuel Futier, MD, PhD, Département de Médecine Périopératoire, Anesthésie Réanimation,
Hôpital Estaing, 1 place Lucie Aubrac, 63003 Clermont-Ferrand, France (
efutier@
123456chu-clermontferrand.fr
).
Group Information: The INPRESS Study Group investigators are listed at the end of this article.
Accepted for Publication: August 30, 2017.
Published Online: September 27, 2017. doi:10.1001/jama.2017.14172
Author Contributions: Drs Futier and Jaber had full access to all of the data in the study and take responsibility
for the integrity of the data and the accuracy of the data analysis.
Concept and design: Futier, Lefrant, Julia, Tavernier, Bazin, Constantin, Pereira, Jaber.
Acquisition, analysis, or interpretation of data: Futier, Lefrant, Guinot, Godet, Lorne, Cuvillon, Bertran, Leone, Pastene, Piriou,
Molliex, Albanese, Julia, Imhoff, Constantin, Pereira, Jaber.
Drafting of the manuscript: Futier, Cuvillon, Leone, Tavernier, Pereira, Jaber.
Critical revision of the manuscript for important intellectual content: Futier, Lefrant, Guinot, Godet, Lorne, Bertran, Leone, Pastene, Piriou, Molliex,
Albanese, Julia, Tavernier, Imhoff, Bazin, Constantin, Pereira, Jaber.
Statistical analysis: Pereira.
Obtained funding: Futier, Julia.
Administrative, technical, or material support: Futier, Lefrant, Guinot, Godet, Cuvillon, Leone, Piriou, Julia, Bazin, Jaber.
Supervision: Futier, Godet, Bertran, Julia, Constantin, Jaber.
Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential
Conflicts of Interest. Dr Futier reported receiving consulting fees from Edwards Lifesciences
and Dräger; lecture fees from Dräger, GE Healthcare, Fresenius Kabi, and Fisher and
Paykel Healthcare; and travel reimbursement from Fisher and Paykel Healthcare. Dr
Leone reported receiving personal fees from LFB and Augettant and nonfinancial support
from MSD. Dr Julia reported being an inventor on a patent owned by Aguettant. Dr Bazin
reported receiving honoraria for expertise from General Electric, Ambu, and MSD and
a grant from General Electric. No other disclosures were reported.
Funding/Support: This study was funded by the
University Hospital of Clermont-Ferrand and was supported in part by a grant from
Aguettant.
Role of the Funder/Sponsor: The funders had no role in the design and conduct of the study; collection, management,
analysis, and interpretation of the data; preparation, review, or approval of the
manuscript; and decision to submit the manuscript for publication. The steering committee
designed the study, vouches for protocol adherence, and made the decision to submit
the manuscript for publication. All drugs used in the study were purchased from the
manufacturers, who had no role in the study.
Intraoperative Norepinephrine to Control Arterial Pressure (INPRESS) Study Group Investigators: The INPRESS Study Group investigators are as follows:
Steering Committee: Emmanuel Futier, MD, PhD (principal investigator; Hôpital Estaing, Centre Hospitalier
Universitaire Clermont-Ferrand), Jean-Yves Lefrant, MD, PhD (project scientist; Centre
Hospitalier Universitaire Nîmes, l’Hôpital Carémeau), Samir Jaber, MD, PhD (project
scientist; Centre Hospitalier Universitaire Montpellier, Hôpital Saint-Eloi), Jean-Michel
Julia, MD (project scientist; Clinique du Parc), Jean-Etienne Bazin, MD, PhD (chair;
Centre Hospitalier Universitaire Clermont-Ferrand), and Jean-Michel Constantin, MD,
PhD (vice chair; Centre Hospitalier Universitaire Clermont-Ferrand);
Scientific Committee: Emmanuel Futier, MD, PhD (Hôpital Estaing, Centre Hospitalier Universitaire Clermont-Ferrand),
Samir Jaber, MD, PhD (Centre Hospitalier Universitaire Montpellier, Hôpital Saint-Eloi),
Jean-Yves Lefrant, MD, PhD (Centre Hospitalier Universitaire Nîmes, l’Hôpital Carémeau),
Marc Leone, MD, PhD (Assistance Publique Hôpitaux de Marseille, Hôpital Nord), Matthieu
Biais, MD, PhD (Centre Hospitalier Universitaire de Bordeaux, Hôpital Pellegrin),
and Benoit Tavernier, MD, PhD (Centre Hospitalier Universitaire Lille);
Trial Management Committee: Emmanuel Futier, MD, PhD, Jean-Yves Lefrant, MD, PhD, and Samir Jaber, MD, PhD;
Trial Monitoring and Research Coordinators: Dominique Morand, Christine Rolhion, and Justine Bourdier (Direction de la Recherche
Clinique, Centre Hospitalier Universitaire Clermont-Ferrand);
Data and Safety Monitoring Committee: Karim Asehnoune, MD, PhD (Nantes, France), Catherine Paugam-Burtz, MD, PhD (Assistance
Publique Hôpitaux de Paris, Paris, France), and Nicolas Molinari, PhD (biostatistician;
Montpellier, France);
Statistical and Data Coordination: Bruno Pereira, PhD;
Writing Committee: Emmanuel Futier, MD, PhD, Samir Jaber, MD, PhD, and Jean-Michel Constantin, MD, PhD;
and
INPRESS Participating Clinical Centers: Hôpital Estaing, Centre Hospitalier Universitaire Clermont-Ferrand (Antoine Petit,
MD, Sebastien Christophe, MD, Marie Vignaud, MD, Oana Cherbis, MD, Adeline Gerard,
MD, and Emmanuel Futier, MD, PhD), Hospices Civils de Lyon, Centre Hospitalier Lyon
Sud (Vincent Piriou, MD, PhD, Etienne Imhoff, MD, Camille Parent, MD, and Aline Steghens,
MD), Assistance Publique Hôpitaux de Marseille, Hôpital Nord (Marc Leone, MD, PhD,
Marie-France Brunier Mercier, MD, Malik Haddam, MD, Ludovic Richiardone, MD, Clement
Brun, MD, and Remy Bardin, MD), Assistance Publique Hôpitaux de Marseille, Hôpital
de la Conception (Jacques Albanese, MD, PhD), Clinique du Parc (Matthieu Ponrouch,
MD, and Jean-Michel Julia, MD), Centre Hospitalier Universitaire Saint-Etienne (Serge
Molliex, MD, PhD), Centre Hospitalier Universitaire Nîmes, l’Hôpital Carémeau (Jean-Yves
Lefrant, MD, PhD, Philippe Cuvillon, MD, PhD, and Sebastien Bertran, MD), Institut
du Cancer Val d’Aurelle, Montpellier (Gilles Leclerc, MD, and Christian Popescu Horatiu,
MD), and Centre Hospitalier Universitaire Amiens (Emmanuel Lorne, MD, PhD, Pierre-Gregoire
Guinot, MD, PhD, Bruno de Broca, MD, and Marc-Olivier Fischer, MD, PhD).
Additional Contributions: We thank all the patients who participated in the study; the clinical and research
staff at all trial sites, without whose assistance the INPRESS study would never have
been completed; and the monitors of the trial. Dominique Morand (Direction de la Recherche
Clinique, Centre Hospitalier Universitaire Clermont-Ferrand) coordinated the monitoring
of the trial and Mervyn Singer, MD (Bloomsbury Institute of Intensive Care Medicine,
University College London), provided valuable advice during the preparation of the
manuscript; they received no compensation.