Synthesis and biological activity of Schiff and Mannich bases bearing 2,4-dichloro-5-fluorophenyl moiety.

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Abstract

A series of 2,4-dichloro-5-fluorophenyl bearing Mannich base (4 and 5) was prepared from triazole Schiff bases (3) by aminomethylation with formaldehyde and secondary/substituted primary amines. All newly synthesized compounds were screened for their antimicrobial activity. Compounds 3c, 4c, 4e and 4f exhibited promising antibacterial and compounds 3c, 5c, 5e and 5f showed good antifungal activity.

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Journal

Journal ID (iso-abbrev): Bioorg Med Chem

Title: Bioorganic & medicinal chemistry

Publisher: Elsevier BV

ISSN: 0968-0896

ISSN (Print): 0968-0896

Publication date (Electronic): Nov 15 2006

Volume: 14

Issue: 22

Affiliations

[1 ] Department of Chemistry, Mangalore University, Mangalagangothri 574199, India. karthims02@rediffmail.com

Article

Publisher Item ID: S0968-0896(06)00569-4

DOI: 10.1016/j.bmc.2006.07.015

PubMed ID: 16879972

SO-VID: 9d0e35b8-f381-47e9-bfa9-8afba276156a

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