Somatic Variants in DNA Damage Response Genes in Ovarian Cancer Patients Using Whole-exome Sequencing.

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Abstract

Several clinical trials have investigated homologous recombination deficiency and BRCA1/2 status to select ovarian cancer patients for treatment with poly(ADP-ribose) polymerase-inhibitors (PARPi), but less attention has been given to other DNA-damage response (DDR) pathways. Therefore, we investigated somatic single/multiple nucleotide variants and small insertions/deletions in exonic and splice-site regions of 356 DDR genes to examine whether genes other than BRCA1/2 are altered.

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Journal

Journal ID (iso-abbrev): Anticancer Res

Title: Anticancer research

Publisher: Anticancer Research USA Inc.

ISSN (Electronic): 1791-7530

ISSN (Print): 0250-7005

Publication date (Electronic): May 2023

Volume: 43

Issue: 5

Affiliations

[1 ] Department of Pathology, Herlev Hospital, University of Copenhagen, Herlev, Denmark.

[2 ] Department of Gynaecology, Juliane Marie Centre, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

[3 ] Department of Pathology, Herlev Hospital, University of Copenhagen, Herlev, Denmark; estrid.hoegdall@regionh.dk.

Article

Publisher Item ID: 43/5/1891

DOI: 10.21873/anticanres.16348

PubMed ID: 37097678

SO-VID: 9cfe7191-db7f-4223-b5ee-de582a39524a

History

Keywords: DNA damage response,Somatic variants,ovarian cancer

Data availability:

Keywords: DNA damage response, Somatic variants, ovarian cancer

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