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      Generalized granuloma annulare associated with essential thrombocythemia

      case-report

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          Abstract

          The only myeloproliferative neoplasm associated with generalized granuloma annulare (GA) is chronic myelogenous leukemia (CML). We present the first reported case of GA in a patient with essential thrombocythemia (ET). Future work investigating the shared pathophysiology of GA‐associated CML and ET may improve our understanding of GA pathophysiology and treatment.

          Abstract

          The only myeloproliferative neoplasm associated with generalized granuloma annulare (GA) is chronic myelogenous leukemia (CML). We present the first reported case of GA in a patient with essential thrombocythemia (ET). Future work investigating the shared pathophysiology of GA‐associated CML and ET may improve our understanding of GA pathophysiology and treatment.

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          Janus kinase inhibition induces disease remission in cutaneous sarcoidosis and granuloma annulare

          William Damsky, Durga Thakral, Meaghan K. McGeary … (2019)
          Sarcoidosis and granuloma annulare (GA) are cutaneous granulomatous disorders that can be difficult to treat. There is evidence of underlying Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway activation in sarcoidosis, suggesting that JAK inhibition might be effective.
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            Granuloma annulare

            Misha Rosenbach, Evan W. Piette (2016)
            Granuloma annulare (GA) represents a cutaneous reaction pattern of unknown cause with a variety of previously described potential disease associations and triggers. This review attempts to synthesize the available data regarding potential etiopathogenesis, reviews the available data on potential GA disease associations and work-up indicated for patients with GA, and discusses potential inciting triggers. In the final part, this article describes the available treatments options and supporting data, and provides a framework for approaching management of patients with GA. The previous accompanying article provided a comprehensive overview of the available information known about the clinical variants, epidemiology, genetics, and histology of GA.
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              Granuloma annulare skin profile shows activation of Th1, Th2, and JAK pathways

              Michelle Min, Jianni Wu, Helen He … (2019)
              Granuloma annulare (GA) is an inflammatory skin disorder. Localized GA is often self-resolving, but generalized GA is often recalcitrant to treatments. There are no targeted treatments for GA, largely due to lack of mechanistic understanding. Recently, tumor necrosis factor antagonism showed promise in GA, suggesting an underlying immune pathogenesis.
              Article 0 comments Cited 23 times – based on 0 reviews     Review now
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                Author and article information

                Contributors
                Sai P. Polineni:
                ORCID: https://orcid.org/0000-0002-2948-3275
                spp50@med.miami.edu
                Journal
                Journal ID (nlm-ta): Clin Case Rep
                Journal ID (iso-abbrev): Clin Case Rep
                Journal ID (doi): 10.1002/(ISSN)2050-0904
                Journal ID (publisher-id): CCR3
                Title: Clinical Case Reports
                Publisher: John Wiley and Sons Inc. (Hoboken )
                ISSN (Electronic): 2050-0904
                Publication date (Electronic): 23 March 2020
                Publication date Collection: June 2020
                Volume: 8
                Issue: 6 ( doiID: 10.1002/ccr3.v8.6 )
                Pages: 1065-1068
                Affiliations
                [ 1 ] University of Miami Miller School of Medicine Miami Florida
                [ 2 ] Good Health Clinic Tavernier Florida
                Author notes
                [*] [* ] Correspondence

                Sai P. Polineni, University of Miami Miller School of Medicine, Miami, FL.

                Email: spp50@ 123456med.miami.edu

                Author information
                https://orcid.org/0000-0002-2948-3275
                Article
                Publisher ID: CCR32812
                DOI: 10.1002/ccr3.2812
                PMC ID: 7303850
                SO-VID: 9ca31192-05ee-4807-9cdf-0c2e5fa99608
                Copyright © © 2020 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd.
                License:

                This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

                History
                Date received : 12 February 2020
                Date revision received : 29 February 2020
                Date accepted : 02 March 2020
                Page count
                Figures: 3, Tables: 0, Pages: 4, Words: 1666
                Categories
                Subject: Case Report
                Subject: Case Reports
                Custom metadata
                source-schema-version-number 2.0
                cover-date June 2020
                details-of-publishers-convertor Converter:WILEY_ML3GV2_TO_JATSPMC version:5.8.4 mode:remove_FC converted:19.06.2020

                Keywords: essential thrombocythemia,generalized granuloma annulare,jak2,janus kinase 2,myeloproliferative neoplasm
                Data availability:
                Keywords: essential thrombocythemia, generalized granuloma annulare, jak2, janus kinase 2, myeloproliferative neoplasm

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