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      • Record: found
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      Prognostic Value of lncRNA PVT1 for Patients with Gastric Cancer: A Meta-Analysis

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      Author(s): 1 , 2 , 3 , 1 , 2 , 4 , 1 , 2 ,
      Publication date (Electronic):
      Journal: Disease Markers
      Publisher: Hindawi

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          Abstract

          Objective

          To evaluate the prognostic value of lncRNA PVT1 for patients with gastric cancer.

          Methods

          A comprehensive literature searching was performed in PubMed, Cochrane Library, Web of Science, Embase, CNKI, CBM, and Wanfang Database to identify published studies on the expression level of lncRNA PVT1 in human gastric cancer. STATA 12.0 was conducted to perform the meta-analysis. Clinical outcomes including patients' age, genders, TNM stage, OS, and DFS were assessed in the study.

          Results

          A total of 8 studies involving 747 patients were included in this meta-analysis. The results of meta-analysis showed that higher expression level of lncRNA PVT1 was associated with GC patients' gender (for male: OR = 2.27, 95% CI: 1.67~3.07, P = 0.000), invasion depth (for T3~4: OR = 3.98, 95% CI: 2.85~5.56, P = 0.000), poorer OS (HR = 1.68, 95% CI: 1.43~1.97, P = 0.000), and DFS (HR = 1.74, 95% CI: 1.44~2.08, P = 0.000).

          Conclusion

          Higher expression level of lncRNA PVT1 is significantly associated with GC patients' gender, invasion depth, poorer OS, and worse DFS. lncRNA PVT1 might act as a novel predictive biomarker of poor prognosis and clinicopathological characteristics for gastric cancer.

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          Most cited references31

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          Functional Classification and Experimental Dissection of Long Noncoding RNAs

          Florian Kopp, Joshua Mendell (2018)
          Over the last decade, it has been increasingly demonstrated that the genomes of many species are pervasively transcribed, resulting in the production of numerous long noncoding RNAs (lncRNAs). At the same time, it is now appreciated that many types of DNA regulatory elements, such as enhancers and promoters, regularly initiate bidirectional transcription. Thus, discerning functional noncoding transcripts from a vast transcriptome is a paramount priority, and challenge, for the lncRNA field. In this review, we aim to provide a conceptual and experimental framework for classifying and elucidating lncRNA function. We categorize lncRNA loci into those that regulate gene expression in cis versus those that perform functions in trans , and propose an experimental approach to dissect lncRNA activity based on these classifications. These strategies to further understand lncRNAs promise to reveal new and unanticipated biology, with great potential to advance our understanding of normal physiology and disease.
          Article 0 comments Cited 1327 times – based on 0 reviews     Review now
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            • Record: found
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            Is Open Access

            Newcastle-Ottawa Scale: comparing reviewers’ to authors’ assessments

            Carson Lo, Dominik Mertz, Mark Loeb (2014)
            Background Lack of appropriate reporting of methodological details has previously been shown to distort risk of bias assessments in randomized controlled trials. The same might be true for observational studies. The goal of this study was to compare the Newcastle-Ottawa Scale (NOS) assessment for risk of bias between reviewers and authors of cohort studies included in a published systematic review on risk factors for severe outcomes in patients infected with influenza. Methods Cohort studies included in the systematic review and published between 2008–2011 were included. The corresponding or first authors completed a survey covering all NOS items. Results were compared with the NOS assessment applied by reviewers of the systematic review. Inter-rater reliability was calculated using kappa (K) statistics. Results Authors of 65/182 (36%) studies completed the survey. The overall NOS score was significantly higher (p < 0.001) in the reviewers’ assessment (median = 6; interquartile range [IQR] 6–6) compared with those by authors (median = 5, IQR 4–6). Inter-rater reliability by item ranged from slight (K = 0.15, 95% confidence interval [CI] = −0.19, 0.48) to poor (K = −0.06, 95% CI = −0.22, 0.10). Reliability for the overall score was poor (K = −0.004, 95% CI = −0.11, 0.11). Conclusions Differences in assessment and low agreement between reviewers and authors suggest the need to contact authors for information not published in studies when applying the NOS in systematic reviews.
            Article 0 comments Cited 741 times – based on 0 reviews     Review now
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              Circular RNA profile identifies circPVT1 as a proliferative factor and prognostic marker in gastric cancer.

              Yu Xu, Ziwen Long, Ye Zhou … (2017)
              Circular RNAs (circRNAs) comprise a novel class of widespread non-coding RNAs that may regulate gene expression in eukaryotes. However, the characterization and function of circRNAs in human cancer remain elusive. Here we identified at least 5500 distinct circRNA candidates and a series of circRNAs that are differentially expressed in gastric cancer (GC) tissues compared with matched normal tissues. We further characterized one circRNA derived from the PVT1 gene and termed it as circPVT1. The expression of circPVT1 is often upregulated in GC tissues due to the amplification of its genomic locus. circPVT1 may promote cell proliferation by acting as a sponge for members of the miR-125 family. The level of circPVT1 was observed as an independent prognostic marker for overall survival and disease-free survival of patients with GC. Our findings suggest that circPVT1 is a novel proliferative factor and prognostic marker in GC.
              Article 0 comments Cited 171 times – based on 0 reviews     Review now
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                Author and article information

                Contributors
                Xiaojun Huang:
                ORCID: https://orcid.org/0000-0002-1196-9381
                Journal
                Journal ID (nlm-ta): Dis Markers
                Journal ID (iso-abbrev): Dis Markers
                Journal ID (publisher-id): DM
                Title: Disease Markers
                Publisher: Hindawi
                ISSN (Print): 0278-0240
                ISSN (Electronic): 1875-8630
                Publication date Collection: 2021
                Publication date (Electronic): 2 December 2021
                Volume: 2021
                Electronic Location Identifier: 5595965
                Affiliations
                1Department of Gastroenterology, Lanzhou University Second Hospital, Lanzhou, China
                2Gansu Provincial Digestive Endoscopy Engineering Research Center, Lanzhou, China
                3Department of General Surgery, Lanzhou University Second Hospital, Lanzhou, China
                4First Clinical Medical College, Lanzhou University, Lanzhou, China
                Author notes

                Academic Editor: Muhammad Tahir ul Qamar

                Author information
                https://orcid.org/0000-0001-8277-8294
                https://orcid.org/0000-0002-1196-9381
                Article
                DOI: 10.1155/2021/5595965
                PMC ID: 8660201
                PubMed ID: 34900027
                SO-VID: 9b45d192-8fda-4c1e-ab03-302cf1610905
                Copyright © Copyright © 2021 Jinyong Hao et al.
                License:

                This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                Date received : 2 March 2021
                Date revision received : 24 September 2021
                Date accepted : 15 October 2021
                Funding
                Funded by: Youth Science and Technology Plan Project of Gansu Province
                Award ID: 20JR10RA755
                Funded by: Key Research and Development Project of Gansu Province
                Award ID: 20YF8FA076
                Categories
                Subject: Research Article

                Data availability:

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