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      Insect-Protected Event DAS-81419-2 Soybean ( Glycine max L.) Grown in the United States and Brazil Is Compositionally Equivalent to Nontransgenic Soybean

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          Abstract

          The transgenic soybean event DAS-81419-2 contains genes that encode the Cry1F, Cry1Ac, and PAT proteins. Cry1F and Cry1Ac provide protection against key lepidopteran insect pests, while PAT confers tolerance to the herbicide glufosinate. To satisfy regulatory requirements for the safety evaluation of transgenic crops, studies were conducted in the United States and Brazil to evaluate the nutrient and antinutrient composition of event DAS-81419-2 soybean. On the basis of the results of these studies, event DAS-81419-2 soybean is compositionally equivalent to nontransgenic soybean. This conclusion concurs with numerous other published studies in soybean and other crops where compositional equivalence between the transgenic crop and its nontransgenic comparator has been demonstrated.

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          Bacillus thuringiensis and its pesticidal crystal proteins.

          E Schnepf, N Crickmore, J Van Rie … (1998)
          During the past decade the pesticidal bacterium Bacillus thuringiensis has been the subject of intensive research. These efforts have yielded considerable data about the complex relationships between the structure, mechanism of action, and genetics of the organism's pesticidal crystal proteins, and a coherent picture of these relationships is beginning to emerge. Other studies have focused on the ecological role of the B. thuringiensis crystal proteins, their performance in agricultural and other natural settings, and the evolution of resistance mechanisms in target pests. Armed with this knowledge base and with the tools of modern biotechnology, researchers are now reporting promising results in engineering more-useful toxins and formulations, in creating transgenic plants that express pesticidal activity, and in constructing integrated management strategies to insure that these products are utilized with maximum efficiency and benefit.
          Article 0 comments Cited 314 times – based on 0 reviews     Review now
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            Comparison of two GM maize varieties with a near-isogenic non-GM variety using transcriptomics, proteomics and metabolomics.

            J. M. Dijk, Richard M Röhlig, Andreas Engel … (2010)
            The aim of this study was to evaluate the use of four nontargeted analytical methodologies in the detection of unintended effects that could be derived during genetic manipulation of crops. Three profiling technologies were used to compare the transcriptome, proteome and metabolome of two transgenic maize lines with the respective control line. By comparing the profiles of the two transgenic lines grown in the same location over three growing seasons, we could determine the extent of environmental variation, while the comparison with the control maize line allowed the investigation of effects caused by a difference in genotype. The effect of growing conditions as an additional environmental effect was also evaluated by comparing the Bt-maize line with the control line from plants grown in three different locations in one growing season. The environment was shown to play an important effect in the protein, gene expression and metabolite levels of the maize samples tested where 5 proteins, 65 genes and 15 metabolites were found to be differentially expressed. A distinct separation between the three growing seasons was also found for all the samples grown in one location. Together, these environmental factors caused more variation in the different transcript/protein/metabolite profiles than the different genotypes.
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              A metabolomic study of substantial equivalence of field-grown genetically modified wheat.

              John Baker, Nathaniel D Hawkins, Jane Ward … (2006)
              The 'substantial equivalence' of three transgenic wheats expressing additional high-molecular-weight subunit genes and the corresponding parental lines (two lines plus a null transformant) was examined using metabolite profiling of samples grown in replicate field trials on two UK sites (Rothamsted, Hertfordshire and Long Ashton, near Bristol) for 3 years. Multivariate comparison of the proton nuclear magnetic resonance spectra of polar metabolites extracted with deuterated methanol-water showed a stronger influence of site and year than of genotype. Nevertheless, some separation between the transgenic and parental lines was observed, notably between the transgenic line B73-6-1 (which had the highest level of transgene expression) and its parental line L88-6. Comparison of the spectra showed that this separation resulted from increased levels of maltose and/or sucrose in this transgenic line, and that differences in free amino acids were also apparent. More detailed studies of the amino acid composition of material grown in 2000 were carried out using gas chromatography-mass spectrometry. The most noticeable difference was that the samples grown at Rothamsted consistently contained larger amounts of acidic amino acids (glutamic, aspartic) and their amides (glutamine, asparagine). In addition, the related lines, L88-6 and B73-6-1, both contained larger amounts of proline and gamma-aminobutyric acid when grown at Long Ashton than at Rothamsted. The results clearly demonstrate that the environment affects the metabolome and that any differences between the control and transgenic lines are generally within the same range as the differences observed between the control lines grown on different sites and in different years.
              Article 0 comments Cited 60 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (nlm-ta): J Agric Food Chem
                Journal ID (iso-abbrev): J. Agric. Food Chem
                Journal ID (publisher-id): jf
                Journal ID (coden): jafcau
                Title: Journal of Agricultural and Food Chemistry
                Publisher: American Chemical Society
                ISSN (Print): 0021-8561
                ISSN (Electronic): 1520-5118
                Publication date (Electronic): 01 February 2015
                Publication date (Print): 25 February 2015
                Volume: 63
                Issue: 7
                Pages: 2063-2073
                Affiliations
                [† ]Dow AgroSciences LLC , 9330 Zionsville Road, Indianapolis, Indiana 46268, United States
                [‡ ]Dow AgroSciences Industrial Ltda. , Rod. Anhanguera Km 296, Cravinhos, SP 14140-000, Brazil
                [§ ]Covance Laboratories Inc. , 3301 Kinsman Boulevard, Madison, Wisconsin 53704, United States
                Author notes
                [* ]Phone: 317-337-3494. E-mail: BJFast@ 123456dow.com .
                Article
                DOI: 10.1021/jf505015y
                PMC ID: 4342727
                PubMed ID: 25641393
                SO-VID: 9a72040b-6742-454e-824a-24e3560b9b4b
                Copyright © Copyright © 2015 American Chemical Society
                License:

                This is an open access article published under an ACS AuthorChoice License, which permits copying and redistribution of the article or any adaptations for non-commercial purposes.

                History
                Date received : 16 October 2014
                Date accepted : 31 January 2015
                Date revision received : 28 January 2015
                Categories
                Subject: Article
                Custom metadata
                document-id-old-9 jf505015y
                document-id-new-14 jf-2014-05015y
                ccc-price

                ScienceOpen disciplines: Food science & Technology
                Keywords: crop composition,das-81419-2,soybean,safety evaluation,risk assessment
                Data availability:
                ScienceOpen disciplines: Food science & Technology
                Keywords: crop composition, das-81419-2, soybean, safety evaluation, risk assessment

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