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      Fusarium Toxins in Cereals: Occurrence, Legislation, Factors Promoting the Appearance and Their Management

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          Abstract

          Fusarium diseases of small grain cereals and maize cause significant yield losses worldwide. Fusarium infections result in reduced grain yield and contamination with mycotoxins, some of which have a notable impact on human and animal health. Regulations on maximum limits have been established in various countries to protect consumers from the harmful effects of these mycotoxins. Several factors are involved in Fusarium disease and mycotoxin occurrence and among them environmental factors and the agronomic practices have been shown to deeply affect mycotoxin contamination in the field. In the present review particular emphasis will be placed on how environmental conditions and stress factors for the crops can affect Fusarium infection and mycotoxin production, with the aim to provide useful knowledge to develop strategies to prevent mycotoxin accumulation in cereals.

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          Most cited references308

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          Regulation of fungal secondary metabolism.

          Fungi produce a multitude of low-molecular-mass compounds known as secondary metabolites, which have roles in a range of cellular processes such as transcription, development and intercellular communication. In addition, many of these compounds now have important applications, for instance, as antibiotics or immunosuppressants. Genome mining efforts indicate that the capability of fungi to produce secondary metabolites has been substantially underestimated because many of the fungal secondary metabolite biosynthesis gene clusters are silent under standard cultivation conditions. In this Review, I describe our current understanding of the regulatory elements that modulate the transcription of genes involved in secondary metabolism. I also discuss how an improved knowledge of these regulatory elements will ultimately lead to a better understanding of the physiological and ecological functions of these important compounds and will pave the way for a novel avenue to drug discovery through targeted activation of silent gene clusters.
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            Fusarium ear blight (scab) in small grain cereals?a review

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              QTL mapping and marker-assisted selection forFusariumhead blight resistance in wheat: a review

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                Author and article information

                Contributors
                Role: Academic Editor
                Journal
                Molecules
                Molecules
                molecules
                Molecules
                MDPI
                1420-3049
                13 May 2016
                May 2016
                : 21
                : 5
                : 627
                Affiliations
                Department of Land, Environment, Agriculture and Forestry, University of Padua, Campus of Agripolis, Viale Università 16, 35020 Legnaro, Padua, Italy; davide.ferrigo@ 123456unipd.it (D.F.); alessandro.raiola@ 123456unipd.it (A.R.)
                Author notes
                [* ] Correspondence: roberto.causin@ 123456unipd.it ; Tel.: +39-049-8272885
                [†]

                These authors contributed equally to this work.

                Article
                molecules-21-00627
                10.3390/molecules21050627
                6274039
                27187340
                99e3f1e1-5672-4fe1-bc85-10e4188ac675
                © 2016 by the authors.

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license ( http://creativecommons.org/licenses/by/4.0/).

                History
                : 07 March 2016
                : 09 May 2016
                Categories
                Review

                fusarium toxins,fusarium disease,mycotoxin regulation,mycotoxin management

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