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Abstract
Diabetes leads to markedly accelerated rates of many associated macrovascular complications
like hypertension and atherosclerosis, and microvascular complications like nephropathy
and retinopathy. High glucose, the hallmark of diabetes, drives changes in vascular
and inflammatory cells that promote the development of these complications. Understanding
the molecular processes involved in the development of diabetes and its debilitating
complications can lead to much needed newer clinical therapies. Recently, long-noncoding
RNAs (lncRNAs) have been shown to be important in the biology of vascular cells and
there is growing evidence that lncRNAs are also involved in the cell biology relevant
to diabetic vascular complications. In this review, we provide an overview of lncRNAs
that function in vascular cells, and those that have been linked to diabetic complications.