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      Factors associated with acceptance of COVID-19 vaccine among University health sciences students in Northwest Nigeria

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          Abstract

          Students of the health sciences are the future frontliners to fight pandemics. The students’ participation in COVID-19 response varies across countries and are mostly for educational purposes. Understanding the determinants of COVID-19 vaccine acceptability is necessary for a successful vaccination program. This study aimed to investigate the factors associated with COVID-19 vaccine acceptance among health sciences students in Northwest Nigeria. The study was an online self-administered cross-sectional study involving a survey among students of health sciences in some selected universities in Northwest Nigeria. The survey collected pertinent data from the students, including socio-demographic characteristics, risk perception for COVID-19, and willingness to accept the COVID-19 vaccine. Multiple logistic regression was used to determine the predictors of COVID-19 vaccine acceptance. A total of 440 responses with a median (interquartile range) age of 23 (4.0) years were included in the study. The prevalence of COVID-19 vaccine acceptance was 40.0%. Factors that independently predict acceptance of the vaccine were age of 25 years and above (adjusted odds ratio, aOR, 2.72; 95% confidence interval, CI, 1.44–5.16; p = 0.002), instructions from heads of institutions (aOR, 11.71; 95% CI, 5.91–23.20; p<0.001), trust in the government (aOR, 20.52; 95% CI, 8.18–51.51; p<0.001) and willingness to pay for the vaccine (aOR, 7.92; 95% CI, 2.63–23.85; p<0.001). The prevalence of COVID-19 vaccine acceptance among students of health sciences was low. Older age, mandate by heads of the institution, trust in the government and readiness to pay for the vaccine were associated with acceptance of the vaccine. Therefore, stakeholders should prioritize strategies that would maximize the vaccination uptake.

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          Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies.

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            Vaccine hesitancy: Definition, scope and determinants.

            The SAGE Working Group on Vaccine Hesitancy concluded that vaccine hesitancy refers to delay in acceptance or refusal of vaccination despite availability of vaccination services. Vaccine hesitancy is complex and context specific, varying across time, place and vaccines. It is influenced by factors such as complacency, convenience and confidence. The Working Group retained the term 'vaccine' rather than 'vaccination' hesitancy, although the latter more correctly implies the broader range of immunization concerns, as vaccine hesitancy is the more commonly used term. While high levels of hesitancy lead to low vaccine demand, low levels of hesitancy do not necessarily mean high vaccine demand. The Vaccine Hesitancy Determinants Matrix displays the factors influencing the behavioral decision to accept, delay or reject some or all vaccines under three categories: contextual, individual and group, and vaccine/vaccination-specific influences.
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              COVID-19 infection: Origin, transmission, and characteristics of human coronaviruses

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                Author and article information

                Contributors
                Role: ConceptualizationRole: Formal analysisRole: MethodologyRole: ResourcesRole: ValidationRole: VisualizationRole: Writing – original draftRole: Writing – review & editing
                Role: ConceptualizationRole: Formal analysisRole: InvestigationRole: MethodologyRole: ValidationRole: Writing – review & editing
                Role: ConceptualizationRole: MethodologyRole: SoftwareRole: SupervisionRole: Writing – original draftRole: Writing – review & editing
                Role: Data curationRole: Formal analysisRole: Project administrationRole: SupervisionRole: Writing – original draft
                Role: ConceptualizationRole: Data curationRole: Formal analysisRole: SoftwareRole: ValidationRole: VisualizationRole: Writing – original draft
                Role: ConceptualizationRole: Data curationRole: InvestigationRole: MethodologyRole: Project administrationRole: Writing – review & editing
                Role: Formal analysisRole: InvestigationRole: MethodologyRole: Project administrationRole: Writing – review & editing
                Role: InvestigationRole: MethodologyRole: Project administrationRole: SoftwareRole: Writing – original draft
                Role: Data curationRole: InvestigationRole: SoftwareRole: ValidationRole: VisualizationRole: Writing – review & editing
                Role: Formal analysisRole: InvestigationRole: Project administrationRole: SoftwareRole: Writing – review & editing
                Role: Data curationRole: Formal analysisRole: SoftwareRole: ValidationRole: Writing – original draft
                Role: InvestigationRole: Project administrationRole: SoftwareRole: VisualizationRole: Writing – review & editing
                Role: Data curationRole: Formal analysisRole: Project administrationRole: SoftwareRole: ValidationRole: Writing – review & editing
                Role: InvestigationRole: MethodologyRole: Project administrationRole: ValidationRole: VisualizationRole: Writing – review & editing
                Role: Project administrationRole: SoftwareRole: SupervisionRole: ValidationRole: Writing – original draftRole: Writing – review & editing
                Role: Editor
                Journal
                PLoS One
                PLoS One
                plos
                PLoS ONE
                Public Library of Science (San Francisco, CA USA )
                1932-6203
                29 November 2021
                2021
                29 November 2021
                : 16
                : 11
                : e0260672
                Affiliations
                [1 ] School of Pharmaceutical Sciences, Universiti Sains Malaysia, Minden, Pulau Pinang, Malaysia
                [2 ] Faculty of Pharmaceutical Sciences, Department of Clinical Pharmacy and Pharmacy Practice, Ahmadu Bello University, Zaria, Kaduna, Nigeria
                [3 ] Faculty of Pharmaceutical Sciences, Department of Clinical Pharmacy and Pharmacy Management, Kaduna State University, Kaduna, Nigeria
                [4 ] School of Pharmacy and Pharmacology, University of Tasmania, Hobart, Australia
                [5 ] Department of Pharmacology and Therapeutics, Bayero University Kano, Kano, Nigeria
                [6 ] Department of Pharmacology, College of Medicine and Health Sciences, Federal University Dutse, Jigawa, Nigeria
                [7 ] Department of Pharmacology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia
                [8 ] Faculty of Pharmaceutical Sciences, Department of Pharmacology and Therapeutics, Ahmadu Bello University, Zaria, Kaduna, Nigeria
                [9 ] Faculty of Pharmaceutical Sciences, Department of Pharmaceutical and Medicinal Chemistry, Kaduna State University, Kaduna, Nigeria
                [10 ] Department of Pharmaceutics and PharmaceuticalTechnology, Bayero University Kano, Kano, Nigeria
                [11 ] Faculty of Veterinary Medicine, Ahmadu Bello University, Zaria, Kaduna, Nigeria
                [12 ] School of Dental Health Sciences, Shehu Idris Institute of Health Sciences and Technology, Kaduna State University, Makarfi, Kaduna, Nigeria
                [13 ] Faculty of Pharmaceutical Sciences, Department of Pharmacology and Toxicology, Kaduna State University, Kaduna, Nigeria
                University of South Carolina College of Pharmacy, UNITED STATES
                Author notes

                Competing Interests: The authors have declared that no competing interests exist.

                Author information
                https://orcid.org/0000-0002-5021-1610
                https://orcid.org/0000-0003-1975-0648
                https://orcid.org/0000-0003-0402-9639
                Article
                PONE-D-21-25604
                10.1371/journal.pone.0260672
                8629299
                34843594
                994152e5-4a5d-408d-9b04-8e0e2ab67980
                © 2021 Mohammed et al

                This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

                History
                : 20 August 2021
                : 12 November 2021
                Page count
                Figures: 1, Tables: 4, Pages: 15
                Funding
                The author(s) received no specific funding for this work.
                Categories
                Research Article
                Medicine and Health Sciences
                Medical Conditions
                Infectious Diseases
                Infectious Disease Control
                Vaccines
                Medicine and Health Sciences
                Medical Conditions
                Infectious Diseases
                Viral Diseases
                Covid 19
                Medicine and Health Sciences
                Medical Conditions
                Infectious Diseases
                Infectious Disease Control
                Vaccines
                Viral Vaccines
                Biology and Life Sciences
                Microbiology
                Virology
                Viral Vaccines
                Medicine and Health Sciences
                People and Places
                Geographical Locations
                Africa
                Nigeria
                Biology and Life Sciences
                Immunology
                Vaccination and Immunization
                Medicine and Health Sciences
                Immunology
                Vaccination and Immunization
                Medicine and Health Sciences
                Public and Occupational Health
                Preventive Medicine
                Vaccination and Immunization
                Research and Analysis Methods
                Research Design
                Survey Research
                Surveys
                Medicine and Health Sciences
                Epidemiology
                Medical Risk Factors
                Custom metadata
                Data are available at https://doi.org/10.6084/m9.figshare.16920100.v1.
                COVID-19

                Uncategorized
                Uncategorized

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