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      • Record: found
      • Abstract: found
      • Article: found

      Simulation in Perimetry – Program Perisim 2000

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          Abstract

          The program Perisim 2000 enables one to simulate the interaction of a number of visual field examination strategies with a number of stored visual fields, both normal and pathological, with several patterns of observer (patient) behavior. A considerable number of visual fields, patient behavior patterns and examination strategies, including a full bracketing strategy, Gonzalez de la Rosa’s tendency-oriented perimetry (TOP) and Weber’s dynamic program, are available. Statistical programs are also incorporated. While the examination strategies to be used in the simulations must be selected from a predefined list, new visual field and observer patterns may be defined by the user. The results may be shown as numerical tables, symbolic or gray tone, pseudocolor or profile displays. Cumulative defect curves may also be selected. The learning/teaching benefits of the program Perisim 2000 are considerable. It is easy to understand and to operate, and ample explanations are available at each step of the program.

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          Most cited references3

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          Quantification of interpoint topographic correlations of threshold values in glaucomatous visual fields.

          Augusto Azuara-Blanco, David Manuel Folgado-de la Rosa, Maximino Abraldes … (2002)
          The authors sought to quantify neighboring and distant interpoint correlations of threshold values within the visual field in patients with glaucoma. Visual fields of patients with confirmed or suspected glaucoma were analyzed (n = 255). One eye per patient was included. Patients were examined using the 32 program of the Octopus 1-2-3. Linear regression analysis among each of the locations and the rest of the points of the visual field was performed, and the correlation coefficient was calculated. The degree of correlation was categorized as high (r(2) > 0.66), moderate (0.66 > or = r(2) > 0.33), or low (r(2) < or = 0.33). The standard error of threshold estimation was calculated. Most locations of the visual field had high and moderate correlations with neighboring points and with distant locations corresponding to the same nerve fiber bundle. Locations of the visual field had low correlations with those of the opposite hemifield, with the exception of locations temporal to the blind spot. The standard error of threshold estimation increased from 0.6 to 0.9 dB with an r(2) reduction of 0.1. Locations of the visual field have highest interpoint correlation with neighboring points and with distant points in areas corresponding to the distribution of the retinal nerve fiber layer. The quantification of interpoint correlations may be useful in the design and interpretation of visual field tests in patients with glaucoma.
          Article 0 comments Cited 9 times – based on 0 reviews     Review now
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            Perimetry—The information theoretical basis for its automation

            Pierre Koch, Alfred Roulier, Franz Fankhauser (1972)
            Article 0 comments Cited 3 times – based on 0 reviews     Review now
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              2-[ 125 I]Iodomelatonin Binding Sites in the Quail Liver: Characterization and the Effect of Guanosine 5´- O -(3-Thiotriphosphate)

              Q Wan, S.F. Pang (1995)
              Melatonin receptors were studied in quail livers using the melatonin agonist 2-[ 125 I]iodomelatonin ([ 125 I]MEL) as the radioligand. The specific binding of [ 125 I]MEL to membrane preparations of liver was rapid, stable, saturable, reversible and of high affinity. Scatchard analysis of the specific binding data indicated an equilibrium dissociation constant (K d ) of 19.4 ± 1.01 pmol/l (n = 7) and a maximum number of binding sites (B max ) of 1.16 ±0.19 fmol/mg protein (n = 7) in the quail liver collected at mid-light. The Hill coefficient approached 1.0, suggesting a single class of [ 125 I]MEL binding sites in the quail liver. The diurnal variation study showed that the value of K d was 64.4% higher (p max . The kinetic analysis showed that the K d value was 25.0 ± 3.94 pmol/l at mid-light, which was comparable with values determined from saturation studies. Aside from 2-iodomelatonin, melatonin and 6-chloromelatonin, all indole analogs and neurotransmitters tested in inhibition studies had slight or no displacement of [ 125 I]MEL binding. These studies demonstrated that [ 125 I]MEL binding sites were highly specific for melatonin. The presence of 10 and 50 µmoI/l guanosine 5´- O -(3-thiotriphosphate) significantly increased (p d values and depressed the B max values, proposing that [ 125 I]MEL binding sites in quail livers were coupled to a G-protein. Our results indicate that melatonin may exert a direct action on liver functions.
              Article 0 comments Cited 1 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (publisher-id): OPH
                Journal ID (nlm-ta): Ophthalmologica
                Journal ID (doi): 10.1159/issn.0030-3755
                Title: Ophthalmologica
                Publisher: S. Karger AG
                ISSN (Print): 0030-3755
                ISSN (Electronic): 1423-0267
                Publication date Subscription-year: 2005
                Publication date (Print): June 2005
                Publication date (Electronic): 08 June 2005
                Volume: 219
                Issue: 3
                Pages: 123-128
                Affiliations
                aLindenhofspital, Bern, Schweiz; bInstitute of Gerontology, Kings College, London, UK
                Article
                Publisher ID: 85243 Other ID: Ophthalmologica 2005;219:123–128
                DOI: 10.1159/000085243
                PubMed ID: 15947496
                SO-VID: 99366d1f-45a7-43c5-8535-d3c5b07abdd0
                Copyright © © 2005 S. Karger AG, Basel
                License:

                Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

                History
                Date received : 05 May 2004
                Page count
                Figures: 5, Tables: 1, References: 11, Pages: 6
                Categories
                Subject: Review

                ScienceOpen disciplines: Vision sciences,Ophthalmology & Optometry,Pathology
                Keywords: Dynamic program,Perisim 2000,Tendency-oriented perimetry program,Perimetry simulation,Octopus
                Data availability:
                ScienceOpen disciplines: Vision sciences, Ophthalmology & Optometry, Pathology
                Keywords: Dynamic program, Perisim 2000, Tendency-oriented perimetry program, Perimetry simulation, Octopus

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