Manganese: recent advances in understanding its transport and neurotoxicity.

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Abstract

The present review is based on presentations from the meeting of the Society of Toxicology in San Diego, CA (March 2006). It addresses recent developments in the understanding of the transport of manganese (Mn) into the central nervous system (CNS), as well as brain imaging and neurocognitive studies in non-human primates aimed at improving our understanding of the mechanisms of Mn neurotoxicity. Finally, we discuss potential therapeutic modalities for treating Mn intoxication in humans.

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Journal

Journal ID (iso-abbrev): Toxicol Appl Pharmacol

Title: Toxicology and applied pharmacology

Publisher: Elsevier BV

ISSN: 0041-008X

ISSN (Print): 0041-008X

Publication date (Electronic): Jun 01 2007

Volume: 221

Issue: 2

Affiliations

[1 ] Department of Pediatrics, and The Kennedy Center for Research on Human Development, Vanderbilt University, School of Medicine, Nashville, TN 37232-2495, USA. michael.aschner@vanderbilt.edu

Article

Publisher Item ID: S0041-008X(07)00106-8 Mid ID: NIHMS25211

DOI: 10.1016/j.taap.2007.03.001

PMC ID: 1950780

PubMed ID: 17466353

SO-VID: 9932f606-a7d4-4d52-a12b-fb92eef27981

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