Role of polymorphic variants of MTR gene A2756G and SHMT1 gene C1420T in the development of prostatic cancer in residents of the Western Siberian Region of Russia.

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Abstract

Allelic variants of folate cycle enzyme genes can contribute to predisposition to cancer. The impact of polymorphic loci A2756G of MTR gene and of C1420T of SHMT1 gene for the risk of prostatic cancer was studied in residents of West Siberia. The frequency of alleles of these loci in patients (N=371) and controls (N=285) was determined and the data were statistically processed. No statistically significant association with prostatic cancer was detected for any of the studied loci.

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Journal

Journal ID (iso-abbrev): Bull Exp Biol Med

Title: Bulletin of experimental biology and medicine

Publisher: Springer Science and Business Media LLC

ISSN (Electronic): 1573-8221

ISSN (Print): 0007-4888

Publication date (Electronic): Feb 2012

Volume: 152

Issue: 4

Affiliations

[1 ] Institute of Chemical Biology and Basic Medicine, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia. hamlet85@yandex.ru

Article

DOI: 10.1007/s10517-012-1554-6

PubMed ID: 22803112

SO-VID: 9924a2cd-8ac8-4748-a2be-5dc95ff89422

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