Clara Restrepo: Role: Writing – original draft
Mónica Gutierrez-Rivas: Role: Methodology
Yolanda M. Pacheco: Role: Conceptualization
Marcial García: Role: Methodology
Julià Blanco: Role: Conceptualization
Luz M. Medrano: Role: Methodology
María A. Navarrete-Muñoz: Role: Methodology
Félix Gutiérrez: Role: Data curationRole: Resources
Pilar Miralles: Role: Data curationRole: Resources
David Dalmau: Role: Data curationRole: Resources
Juan Luis Gómez: Role: Data curationRole: Resources
Miguel Górgolas: Role: Data curationRole: Resources
Alfonso Cabello: Role: Data curationRole: Resources
Salvador Resino:
ORCID: http://orcid.org/0000-0001-8783-0450
Role: ConceptualizationRole: Formal analysis
José M. Benito:
ORCID: http://orcid.org/0000-0002-7172-049X
Role: ConceptualizationRole: Formal analysisRole: Funding acquisitionRole: Project
administrationRole: SoftwareRole: SupervisionRole: ValidationRole: VisualizationRole:
Writing – original draftRole: Writing – review & editing
Norma Rallón: Role: ConceptualizationRole: Formal analysisRole: Funding acquisitionRole: Project
administrationRole: SoftwareRole: SupervisionRole: ValidationRole: VisualizationRole:
Writing – original draftRole: Writing – review & editing
Golo Ahlenstiel: Role: Editor
Journal ID (nlm-ta): PLoS One
Journal ID (iso-abbrev): PLoS ONE
Journal ID (publisher-id): plos
Journal ID (pmc): plosone
Title:
PLoS ONE
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Electronic):
1932-6203
Publication date
(Electronic):
28
March
2019
Publication date Collection: 2019
Volume: 14
Issue: 3
Electronic Location Identifier: e0214421
Affiliations
[1
]
HIV and Viral Hepatitis Research Laboratory, Instituto de Investigación Sanitaria-Fundación
Jiménez Díaz, Universidad Autónoma de Madrid (IIS-FJD, UAM), Madrid, Spain
[2
]
Hospital Universitario Rey Juan Carlos, Móstoles (Madrid), Spain
[3
]
Instituto de Salud Carlos III, Madrid, Spain
[4
]
Laboratory of Immunology, Instituto de Biomedicina de Sevilla (IBiS)/UGC Clinical
Laboratories, Hospital Universitario Virgen del Rocío, Sevilla, Spain
[5
]
IrsiCaixa AIDS Research Institute, Badalona, Spain
[6
]
Hospital General Universitario de Elche & University Miguel Hernández, Alicante, Spain
[7
]
Hospital General Universitario Gregorio Marañón, Madrid, Spain
[8
]
Hospital Universitari Mutua Terrasa, Terrasa, Spain
[9
]
Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain
[10
]
Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain
Western Sydney University, AUSTRALIA
Author notes
Competing Interests: The authors have declared that no competing interests exist.
‡ These authors also contributed equally to this work.
¶ The clinical centers and research groups that contribute to CoRIS and HIV Biobank
are shown in
S1 Text. Lead author for this group: MA Muñoz-Fernández, Laboratory of Molecular Immuno-Biology,
Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria
Gregorio Marañón, Madrid, Spain. e-mail:
mmunoz.hgugm@
123456gmail.com
Author information
Article
Publisher ID:
PONE-D-18-36250
DOI: 10.1371/journal.pone.0214421
PMC ID: 6438540
PubMed ID: 30921390
SO-VID: 98ff1a42-7fa3-4ee0-825e-0ebb3d32471b
Copyright © © 2019 Restrepo et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
This work has been (partially) funded by the Spanish AIDS Research Network RD12/0017/0031,
RD16/0025/0013, RD16CIII/0002/0002, and PI14CIII/00011 projects as part of the Health
Research and Development Strategy, State Plan for Scientific and Technical Research
and Innovation (2008-2011, 2013-2016) and co-financed by Institute of Health Carlos
III, ISCIII-Sub-Directorate General for Research Assessment and Promotion and European
Regional Development Fund (ERDF). M Gutierrez-Rivas is funded by project RD16CIII/0002/0002.
LM Medrano is supported by IISCIII, grant CD14/00002. F. Gutiérrez is supported by
ISCIII, grants PI08/893, PI13/02256 and PI16/01740; FISABIO, grants UGP-14-197 and
UGP-15-232, and RD16/0025/0038. N Rallón is a Miguel Servet investigator from the
ISCIII (grant CP14/00198), Madrid, Spain. MA Navarrete-Muñoz is co-funded by RD16/0025/0013
project and Intramural Research Scholarship from IIS-FJD. M García is co-funded by
CP14/00198 project and Intramural Research Scholarship from IIS-FJD. C Restrepo was
funded by project RD12/0017/0031 and currently is funded by project RD16/0025/0013.
Subject:
Research Article
Subject:
Biology and Life Sciences
Subject:
Genetics
Subject:
Heredity
Subject:
Genetic Mapping
Subject:
Variant Genotypes
Subject:
Biology and Life Sciences
Subject:
Microbiology
Subject:
Medical Microbiology
Subject:
Microbial Pathogens
Subject:
Viral Pathogens
Subject:
Immunodeficiency Viruses
Subject:
HIV
Subject:
Medicine and Health Sciences
Subject:
Pathology and Laboratory Medicine
Subject:
Pathogens
Subject:
Microbial Pathogens
Subject:
Viral Pathogens
Subject:
Immunodeficiency Viruses
Subject:
HIV
Subject:
Biology and Life Sciences
Subject:
Organisms
Subject:
Viruses
Subject:
Viral Pathogens
Subject:
Immunodeficiency Viruses
Subject:
HIV
Subject:
Biology and Life Sciences
Subject:
Organisms
Subject:
Viruses
Subject:
Immunodeficiency Viruses
Subject:
HIV
Subject:
Biology and life sciences
Subject:
Organisms
Subject:
Viruses
Subject:
RNA viruses
Subject:
Retroviruses
Subject:
Lentivirus
Subject:
HIV
Subject:
Biology and Life Sciences
Subject:
Microbiology
Subject:
Medical Microbiology
Subject:
Microbial Pathogens
Subject:
Viral Pathogens
Subject:
Retroviruses
Subject:
Lentivirus
Subject:
HIV
Subject:
Medicine and Health Sciences
Subject:
Pathology and Laboratory Medicine
Subject:
Pathogens
Subject:
Microbial Pathogens
Subject:
Viral Pathogens
Subject:
Retroviruses
Subject:
Lentivirus
Subject:
HIV
Subject:
Biology and Life Sciences
Subject:
Organisms
Subject:
Viruses
Subject:
Viral Pathogens
Subject:
Retroviruses
Subject:
Lentivirus
Subject:
HIV
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Types
Subject:
Animal Cells
Subject:
Blood Cells
Subject:
White Blood Cells
Subject:
T Cells
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Types
Subject:
Animal Cells
Subject:
Immune Cells
Subject:
White Blood Cells
Subject:
T Cells
Subject:
Biology and Life Sciences
Subject:
Immunology
Subject:
Immune Cells
Subject:
White Blood Cells
Subject:
T Cells
Subject:
Medicine and Health Sciences
Subject:
Immunology
Subject:
Immune Cells
Subject:
White Blood Cells
Subject:
T Cells
Subject:
Biology and Life Sciences
Subject:
Genetics
Subject:
Genetic Loci
Subject:
Alleles
Subject:
Medicine and health sciences
Subject:
Infectious diseases
Subject:
Viral diseases
Subject:
HIV infections
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cell Motility
Subject:
Chemotaxis
Subject:
Chemokines
Subject:
Biology and Life Sciences
Subject:
Immunology
Subject:
Immune Response
Subject:
Medicine and Health Sciences
Subject:
Immunology
Subject:
Immune Response
Subject:
Biology and Life Sciences
Subject:
Evolutionary Biology
Subject:
Population Genetics
Subject:
Genetic Polymorphism
Subject:
Biology and Life Sciences
Subject:
Genetics
Subject:
Population Genetics
Subject:
Genetic Polymorphism
Subject:
Biology and Life Sciences
Subject:
Population Biology
Subject:
Population Genetics
Subject:
Genetic Polymorphism