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      Mechanotransduction via the LINC complex regulates DNA replication in myonuclei

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      Journal: The Journal of Cell Biology
      Publisher: Rockefeller University Press

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          Abstract

          Nuclear mechanotransduction has been implicated in the control of chromatin organization and gene expression. Wang et al. show that, in Drosophila myofibers, the LINC complex is required for the regulation of DNA replication and synchronized cell-cycle progression in myonuclei.

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          BoxPlotR: a web tool for generation of box plots.

          Michaela Spitzer, Jan Wildenhain, Juri Rappsilber … (2014)
          Article 0 comments Cited 349 times – based on 0 reviews     Review now
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            RNA polymerase stalling at developmental control genes in the Drosophila melanogaster embryo.

            Julia Zeitlinger, Alexander Stark, Manolis Kellis … (2007)
            It is widely assumed that the key rate-limiting step in gene activation is the recruitment of RNA polymerase II (Pol II) to the core promoter. Although there are well-documented examples in which Pol II is recruited to a gene but stalls, a general role for Pol II stalling in development has not been established. We have carried out comprehensive Pol II chromatin immunoprecipitation microarray (ChIP-chip) assays in Drosophila embryos and identified three distinct Pol II binding behaviors: active (uniform binding across the entire transcription unit), no binding, and stalled (binding at the transcription start site). The notable feature of the approximately 10% genes that are stalled is that they are highly enriched for developmental control genes, which are either repressed or poised for activation during later stages of embryogenesis. We propose that Pol II stalling facilitates rapid temporal and spatial changes in gene activity during development.
            Article 0 comments Cited 258 times – based on 0 reviews     Review now
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              Endoreplication: polyploidy with purpose.

              Hyun Lee, Jean M. Davidson, Robert Duronio (2009)
              A great many cell types are necessary for the myriad capabilities of complex, multicellular organisms. One interesting aspect of this diversity of cell type is that many cells in diploid organisms are polyploid. This is called endopolyploidy and arises from cell cycles that are often characterized as "variant," but in fact are widespread throughout nature. Endopolyploidy is essential for normal development and physiology in many different organisms. Here we review how both plants and animals use variations of the cell cycle, termed collectively as endoreplication, resulting in polyploid cells that support specific aspects of development. In addition, we discuss briefly how endoreplication occurs in response to certain physiological stresses, and how it may contribute to the development of cancer. Finally, we describe the molecular mechanisms that support the onset and progression of endoreplication.
              Article 0 comments Cited 190 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                PubMed ID:: 29650775
                PMC ID:: 5987719
                DOI:: 10.1083/jcb.201708137
                License:
                https://creativecommons.org/licenses/by-nc-sa/4.0/

                ScienceOpen disciplines: Cell biology
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                ScienceOpen disciplines: Cell biology

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