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      Pineal metastasis as first clinical manifestation of colorectal adenocarcinoma: case report Translated title: Metástase pineal como primeira manifestação clinica de adenocarcinoma colorretal: relato de caso

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          Abstract

          Cerebral metastases from colorectal adenocarcinomas occur in 8% of the cases. Diagnosis is usually made when primary disease and widespread metastases are already known. We report the case of a patient with single metastases in the pineal region as the first clinical manifestation of a colorectal adenocarcinoma. A 48-year-old female with Parinaud's syndrome for 15 days prior her admission was evaluated in our clinic. She had no symptoms or signs of colorectal disease. MRI examination revealed an heterogeneous lesion with peritumoral gadolinium enhancement, located in the pineal region. The tumor was radically resected through an infratentorial/supracerebellar approach. Histology showed metastatic carcinoma and immunohistochemical examination showed gastrointestinal tract adenocarcinoma. Metastases to the pineal region are extremely rare and should be considered in the differential diagnosis of tumors of this region.

          Translated abstract

          Metástases cerebrais derivadas de adenocarcinomas colorretais ocorrem em 8% dos casos. Geralmente a doença primária e as metástases em outros órgãos já são conhecidas quando do momento das manifestações neurológicas. Descrevemos um caso de metástase única na região pineal que promoveu a primeira manifestação clínica de adenocarcinoma colorretal. Uma mulher de 48 anos de idade apresentava há quinze dias de sua admissão ao nosso serviço diplopia e síndrome de Parinaud . O exame de ressonância magnética revelou lesão heterogênea localizada na região pineal. O tumor foi completamente retirado por acesso infratentorial/supracerebelar. O exame histológico revelou tumor metastático indiferenciado e o exame imuno-histoquímico demostrou adenocarcinoma do trato gastrointestinal moderadamente diferenciado. Metástases para a região pineal são extremamente raras e devem ser consideradas no diagnóstico diferencial de tumores nesta região.

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          Brain metastases from colon cancer

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            Intracranial metastases to the pineal region. Report of three cases.

            The pineal region is one of the rarest sites in the brain for metastatic involvement of systemic malignant tumors. A review of the literature shows that approximately 70 such cases have been reported previously, and most of them were diagnosed by autopsy. In this brief report we describe three cases of isolated intracranial metastasis to the pineal region that were diagnosed in patients alive. Although occurring rarely, metastatic lesions should be considered in the differential diagnosis of pineal region tumors.
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              Testicular germ cell tumor with pineal metastases

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                Author and article information

                Contributors
                Role: ND
                Role: ND
                Role: ND
                Role: ND
                Journal
                anp
                Arquivos de Neuro-Psiquiatria
                Arq. Neuro-Psiquiatr.
                Academia Brasileira de Neurologia - ABNEURO (São Paulo )
                1678-4227
                March 1999
                : 57
                : 1
                : 92-95
                Affiliations
                [1 ] Curitiba Skull Base Foundation Brazil
                [2 ] Curitiba Skull Base Foundation
                Article
                S0004-282X1999000100018
                10.1590/S0004-282X1999000100018
                98756d17-a29a-48c2-801f-1c90639972e7

                http://creativecommons.org/licenses/by/4.0/

                History
                Product

                SciELO Brazil

                Self URI (journal page): http://www.scielo.br/scielo.php?script=sci_serial&pid=0004-282X&lng=en
                Categories
                NEUROSCIENCES
                PSYCHIATRY

                Neurosciences,Clinical Psychology & Psychiatry
                pineal tumors,cerebral metastases,colorectal adenocarcinoma,tumores da pineal,metástases cerebrais,adenocarcinoma colorretal

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