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      Control of ticks and tick-borne diseases in Africa through improved diagnosis and utilisation of data on acaricide resistance

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          Abstract

          A meeting, sponsored by the Bill and Melinda Gates Foundation (BMGF) and organised by Clinglobal, was held at The International Livestock Research Institute (ILRI) in Nairobi, Kenya, from 19th – to 21st October 2022. The meeting assembled a unique group of experts on tick control in Africa. Academia, international agencies (FAO and ILRI), the private Animal Health sector and government veterinary services were represented. The significant outcomes included: (i) a shared commitment to standardisation and improvement of acaricide resistance bioassay protocols, particularly the widely used larval packet test (LPT); (ii) development of novel molecular assays for detecting acaricide resistance; (3) creation of platforms for disseminating acaricide resistance data to farmers, veterinary service providers and veterinary authorities to enable more rational evidence-based control of livestock ticks. Implementation of enhanced control will be facilitated by several recently established networks focused on control of parasites in Africa and globally, whose activities were presented at the meeting. These include a newly launched community of practice on management of livestock ticks, coordinated by FAO, an African module of the World Association for the Advancement of Veterinary Parasitology (WAAVP-AN) and the MAHABA (Managing Animal Health and Acaricides for a Better Africa) initiative of Elanco Animal Health.

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          Most cited references14

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          The global importance of ticks

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            Strategies for the control of Rhipicephalus microplus ticks in a world of conventional acaricide and macrocyclic lactone resistance

            Infestations with the cattle tick, Rhipicephalus microplus, constitute the most important ectoparasite problem for cattle production in tropical and subtropical regions worldwide, resulting in major economic losses. The control of R. microplus is mostly based on the use of conventional acaricides and macrocyclic lactones. However, the intensive use of such compounds has resulted in tick populations that exhibit resistance to all major acaricide chemical classes. Consequently, there is a need for the development of alternative approaches, possibly including the use of animal husbandry practices, synergized pesticides, rotation of acaricides, pesticide mixture formulations, manual removal of ticks, selection for host resistance, nutritional management, release of sterile male hybrids, environmental management, plant species that are unfavourable to ticks, pasture management, plant extracts, essential oils and vaccination. Integrated tick management consists of the systematic combination of at least two control technologies aiming to reduce selection pressure in favour of acaricide-resistant individuals, while maintaining adequate levels of animal production. The purpose of this paper is to present a current review on conventional acaricide and macrocyclic lactone resistance for better understanding and control of resistant ticks with particular emphasis on R. microplus on cattle.
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              A method for measuring the acaricide-susceptibility of the cattle tick Boophilus microplus (Can.)

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                Author and article information

                Contributors
                bishop5030@gmail.com
                n.githaka@cgiar.org
                TBazarusanga@acreafrica.com
                chandra.bhushan@elancoah.com
                babels005@yahoo.fr
                patrick.vudriko@mak.ac.ug
                dennis.muhanguzi@mak.ac.ug
                tumwebazeaggie@gmail.com
                hortonie2000@gmail.com
                caryn.shacklock@afrivet.co.za
                dr.joskiama@gmail.com
                maxime.madder@clinglobal.com
                christine.maritz@up.ac.za
                weining.zhao@fao.org
                francois.maree@clinglobal.com
                kemimajek@hotmail.com
                lenaig.Halos@gatesfoundation.org
                FJongejan@tbdinternationalbv.com
                alec.evans@clinglobal.com
                Journal
                Parasit Vectors
                Parasit Vectors
                Parasites & Vectors
                BioMed Central (London )
                1756-3305
                6 July 2023
                6 July 2023
                2023
                : 16
                : 224
                Affiliations
                [1 ]GRID grid.30064.31, ISNI 0000 0001 2157 6568, Washington State University, ; Pullman, WA USA
                [2 ]GRID grid.419369.0, ISNI 0000 0000 9378 4481, International Livestock Research Institute (ILRI), ; Nairobi, Kenya
                [3 ]Farmers Solutions Ltd., Kigali, Rwanda
                [4 ]Elanco Animal Health, Monheim am Rhein, Germany
                [5 ]GRID grid.423769.d, ISNI 0000 0004 7592 2050, CIRDES, ; Bobo Dioulasso, Burkina Faso
                [6 ]GRID grid.11194.3c, ISNI 0000 0004 0620 0548, Research Centre for Tropical Diseases and Vector Control (RTC) Makerere University, ; Kampala, Uganda
                [7 ]GRID grid.11194.3c, ISNI 0000 0004 0620 0548, Molecular and Computational Biology Research Group, , Makerere University, ; Kampala, Uganda
                [8 ]Veterinary Office Kiboga District, Kiboga, Uganda
                [9 ]Afrivet Tick Unit, Howick, South Africa
                [10 ]Department of Veterinary Services, Kabete, Kenya
                [11 ]Clinglobal, Tamarin, Mauritius
                [12 ]GRID grid.49697.35, ISNI 0000 0001 2107 2298, Department of Biochemistry, Genetics and Microbiology, , University of Pretoria, ; Pretoria, South Africa
                [13 ]United Nations Food and Agriculture Organisation, Rome, Italy
                [14 ]Clinomics, Bloemfontein, South Africa
                [15 ]GRID grid.420153.1, ISNI 0000 0004 1937 0300, Emergency Centre for Transboundary Diseases (ECTAD), Food and Agriculture Organisation of the United Nations, ; Rome, Italy
                [16 ]GRID grid.418309.7, ISNI 0000 0000 8990 8592, Bill and Melinda Gates Foundation, ; Seattle, WA USA
                Article
                5803
                10.1186/s13071-023-05803-3
                10327166
                37415211
                9872c568-9b74-4acc-8b38-3763eedb7db5
                © The Author(s) 2023

                Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

                History
                : 21 February 2023
                : 8 May 2023
                Funding
                Funded by: FundRef http://dx.doi.org/10.13039/100000865, Bill and Melinda Gates Foundation;
                Award ID: OP12113344
                Award ID: OP12113344
                Award ID: OP12113344
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                Award ID: OP12113344
                Award ID: OP12113344
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                Award ID: OP12113344
                Award ID: OP12113344
                Award ID: OP12113344
                Award ID: OP12113344
                Award ID: OP12113344
                Award ID: OP12113344
                Award ID: OP12113344
                Award ID: OP12113344
                Award ID: OP12113344
                Award Recipient :
                Categories
                Meeting Report
                Custom metadata
                © BioMed Central Ltd., part of Springer Nature 2023

                Parasitology
                acaricide resistance,larval packet test (lpt),ticks,rhipicephalus microplus,rhipicephalus appendiculatus,amidines (amitraz), synthetic pyrethroids, organophosphates

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