For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
14
views
145
references
 Top references
cited by
54
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
1 collections
    0
    shares
      273
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: not found

      COVID–19 and chronic kidney disease: an updated overview of reviews

      review-article

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Background

          Coronavirus disease (COVID–19) has resulted in the death of more than 3.5 million people worldwide. While COVID–19 mostly affects the lungs, different comorbidities can have an impact on its outcomes. We performed an overview of reviews to assess the effect of Chronic Kidney Disease (CKD) on contracting COVID–19, hospitalization, mortality, and disease severity.

          Methods

          We searched published and preprint databases. We updated the reviews by searching for primary studies published after August 2020, and prioritized reviews that are most updated and of higher quality using the AMSTAR tool.

          Results

          We included 69 systematic reviews and 66 primary studies. Twenty-eight reviews reported on the prevalence of CKD among patients with COVID–19, which ranged from 0.4 to 49.0%. One systematic review showed an increased risk of hospitalization in patients with CKD and COVID–19 (RR = 1.63, 95% CI 1.03–2.58) (Moderate certainty). Primary studies also showed a statistically significant increase of hospitalization in such patients. Thirty-seven systematic reviews assessed mortality risk in patients with CKD and COVID–19. The pooled estimates from primary studies for mortality in patients with CKD and COVID–19 showed a HR of 1.48 (95% CI 1.33–1.65) (Moderate certainty), an OR of 1.77 (95% CI 1.54–2.02) (Moderate certainty) and a RR of 1.6 (95% CI 0.88–2.92) (Low certainty).

          Conclusions

          Our review highlights the impact of CKD on the poor outcomes of COVID–19, underscoring the importance of identifying strategies to prevent COVID–19 infection among patients with CKD.

          Graphical abstract

          Supplementary Information

          The online version contains supplementary material available at 10.1007/s40620-021-01206-8.

          Related collections

          Most cited references145

          • Record: found
          • Abstract: not found
          • Article: not found

          GRADE: an emerging consensus on rating quality of evidence and strength of recommendations.

          Gordon Guyatt, Andrew D Oxman, Gunn E. Vist … (2008)
          Article 0 comments Cited 4078 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration

            Alessandro Liberati, Douglas G. Altman, Jennifer Tetzlaff … (2010)
            Systematic reviews and meta-analyses are essential to summarise evidence relating to efficacy and safety of healthcare interventions accurately and reliably. The clarity and transparency of these reports, however, are not optimal. Poor reporting of systematic reviews diminishes their value to clinicians, policy makers, and other users. Since the development of the QUOROM (quality of reporting of meta-analysis) statement—a reporting guideline published in 1999—there have been several conceptual, methodological, and practical advances regarding the conduct and reporting of systematic reviews and meta-analyses. Also, reviews of published systematic reviews have found that key information about these studies is often poorly reported. Realising these issues, an international group that included experienced authors and methodologists developed PRISMA (preferred reporting items for systematic reviews and meta-analyses) as an evolution of the original QUOROM guideline for systematic reviews and meta-analyses of evaluations of health care interventions. The PRISMA statement consists of a 27-item checklist and a four-phase flow diagram. The checklist includes items deemed essential for transparent reporting of a systematic review. In this explanation and elaboration document, we explain the meaning and rationale for each checklist item. For each item, we include an example of good reporting and, where possible, references to relevant empirical studies and methodological literature. The PRISMA statement, this document, and the associated website (www.prisma-statement.org/) should be helpful resources to improve reporting of systematic reviews and meta-analyses.
            Article 0 comments Cited 3736 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: found
              Is Open Access

              OpenSAFELY: factors associated with COVID-19 death in 17 million patients

              Elizabeth J Williamson, Alex J Walker, Krishnan Bhaskaran … (2020)
              COVID-19 has rapidly impacted on mortality worldwide. 1 There is unprecedented urgency to understand who is most at risk of severe outcomes, requiring new approaches for timely analysis of large datasets. Working on behalf of NHS England we created OpenSAFELY: a secure health analytics platform covering 40% of all patients in England, holding patient data within the existing data centre of a major primary care electronic health records vendor. Primary care records of 17,278,392 adults were pseudonymously linked to 10,926 COVID-19 related deaths. COVID-19 related death was associated with: being male (hazard ratio 1.59, 95%CI 1.53-1.65); older age and deprivation (both with a strong gradient); diabetes; severe asthma; and various other medical conditions. Compared to people with white ethnicity, black and South Asian people were at higher risk even after adjustment for other factors (HR 1.48, 1.29-1.69 and 1.45, 1.32-1.58 respectively). We have quantified a range of clinical risk factors for COVID-19 related death in the largest cohort study conducted by any country to date. OpenSAFELY is rapidly adding further patients’ records; we will update and extend results regularly.
              Article 0 comments Cited 3062 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Contributors
                Reem A. Mustafa: rmustafa@kumc.edu
                Journal
                Journal ID (nlm-ta): J Nephrol
                Journal ID (iso-abbrev): J Nephrol
                Title: Journal of Nephrology
                Publisher: Springer International Publishing (Cham )
                ISSN (Print): 1121-8428
                ISSN (Electronic): 1724-6059
                Publication date (Electronic): 11 January 2022
                Pages: 1-17
                Affiliations
                [1 ]GRID grid.17063.33, ISNI 0000 0001 2157 2938, Division of Nephrology, , University of Toronto, ; Toronto, ON Canada
                [2 ]GRID grid.266515.3, ISNI 0000 0001 2106 0692, Division of Nephrology and Hypertension, Department of Internal Medicine, Medical Center, , University of Kansas, ; Kansas City, KS USA
                [3 ]GRID grid.266515.3, ISNI 0000 0001 2106 0692, School of Medicine, , University of Kansas, ; Kansas City, KS USA
                [4 ]GRID grid.25073.33, ISNI 0000 0004 1936 8227, Department of Health Research Methods, Evidence and Impact, , McMaster University, ; Hamilton, ON Canada
                Article
                Publisher ID: 1206
                DOI: 10.1007/s40620-021-01206-8
                PMC ID: 8747880
                PubMed ID: 35013985
                SO-VID: 9811bc28-c2dc-4729-8a58-ef7d8cee5c5f
                Copyright © © The Author(s) under exclusive licence to Italian Society of Nephrology 2021
                License:

                This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.

                History
                Date received : 30 July 2021
                Date accepted : 8 November 2021
                Categories
                Subject: Systematic Reviews

                Keywords: covid–19,sars–cov–2,chronic kidney disease (ckd),mortality,hospitalization
                Data availability:
                Keywords: covid–19, sars–cov–2, chronic kidney disease (ckd), mortality, hospitalization

                Comments

                Comment on this article

                scite_

                Similar content273

                See all similar

                Cited by52

                See all cited by

                Most referenced authors3,991

                See all reference authors