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      Applications of emerging extracellular vesicles technologies in the treatment of inflammatory diseases

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          Abstract

          The emerging extracellular vesicles technologies is an advanced therapeutic approach showing promising potential for addressing inflammatory diseases. These techniques have been proven to have positive effects on immune modulation and anti-inflammatory responses. With these advancements, a comprehensive review and update on the role of extracellular vesicles in inflammatory diseases have become timely. This review aims to summarize the research progress of extracellular vesicle technologies such as plant-derived extracellular vesicles, milk-derived extracellular vesicles, mesenchymal stem cell-derived extracellular vesicles, macrophage-derived extracellular vesicles, etc., in the treatment of inflammatory diseases. It elucidates their potential significance in regulating inflammation, promoting tissue repair, and treating diseases. The goal is to provide insights for future research in this field, fostering the application and development of extracellular vesicle technology in the treatment of inflammatory diseases.

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          Extracellular vesicles: Exosomes, microvesicles, and friends

          Graça Raposo, Willem Stoorvogel (2013)
          Cells release into the extracellular environment diverse types of membrane vesicles of endosomal and plasma membrane origin called exosomes and microvesicles, respectively. These extracellular vesicles (EVs) represent an important mode of intercellular communication by serving as vehicles for transfer between cells of membrane and cytosolic proteins, lipids, and RNA. Deficiencies in our knowledge of the molecular mechanisms for EV formation and lack of methods to interfere with the packaging of cargo or with vesicle release, however, still hamper identification of their physiological relevance in vivo. In this review, we focus on the characterization of EVs and on currently proposed mechanisms for their formation, targeting, and function.
          Article 0 comments Cited 1854 times – based on 0 reviews     Review now
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            Extracellular vesicles: biology and emerging therapeutic opportunities.

            Samir El Andaloussi, Imre Mäger, Xandra O. Breakefield … (2013)
            Within the past decade, extracellular vesicles have emerged as important mediators of intercellular communication, being involved in the transmission of biological signals between cells in both prokaryotes and higher eukaryotes to regulate a diverse range of biological processes. In addition, pathophysiological roles for extracellular vesicles are beginning to be recognized in diseases including cancer, infectious diseases and neurodegenerative disorders, highlighting potential novel targets for therapeutic intervention. Moreover, both unmodified and engineered extracellular vesicles are likely to have applications in macromolecular drug delivery. Here, we review recent progress in understanding extracellular vesicle biology and the role of extracellular vesicles in disease, discuss emerging therapeutic opportunities and consider the associated challenges.
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              Exosomes Facilitate Therapeutic Targeting of Oncogenic Kras in Pancreatic Cancer

              Sushrut Kamerkar, Valerie LeBleu, Hikaru Sugimoto … (2017)
              Summary The mutant form of the GTPase KRAS is a key driver of pancreatic cancer but remains a challenging therapeutic target. Exosomes, extracellular vesicles generated by all cells, are naturally present in the blood. Here we demonstrate that enhanced retention of exosomes in circulation, compared to liposomes, is due to CD47 mediated protection of exosomes from phagocytosis by monocytes and macrophages. Exosomes derived from normal fibroblast-like mesenchymal cells were engineered to carry siRNA or shRNA specific to oncogenic KRASG12D (iExosomes), a common mutation in pancreatic cancer. Compared to liposomes, iExosomes target oncogenic Kras with an enhanced efficacy that is dependent on CD47, and is facilitated by macropinocytosis. iExosomes treatment suppressed cancer in multiple mouse models of pancreatic cancer and significantly increased their overall survival. Our results inform on a novel approach for direct and specific targeting of oncogenic Kras in tumors using iExosomes.
              Article 0 comments Cited 827 times – based on 0 reviews     Review now
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                Author and article information

                Contributors
                Kecheng Lou: URI : https://loop.frontiersin.org/people/1636160Role: Role:
                Hui Luo: Role: Role:
                Xinghua Jiang: Role: Role:
                Shangzhi Feng: URI : https://loop.frontiersin.org/people/1673497Role: Role:
                Journal
                Journal ID (nlm-ta): Front Immunol
                Journal ID (iso-abbrev): Front Immunol
                Journal ID (publisher-id): Front. Immunol.
                Title: Frontiers in Immunology
                Publisher: Frontiers Media S.A.
                ISSN (Electronic): 1664-3224
                Publication date (Electronic): 13 March 2024
                Publication date Collection: 2024
                Volume: 15
                Electronic Location Identifier: 1364401
                Affiliations
                [1] 1 Department of Urology, Jiujiang University Clinic College/Hospital , Jiujiang, Jiangxi, China
                [2] 2 Department of Urology, Lanxi People’s Hospital , Jinhua, Zhejiang, China
                [3] 3 The First Clinical College, Gannan Medical University , Ganzhou, Jiangxi, China
                [4] 4 Department of Urology, Jingdezhen Second People’s Hospital , Jingdezhen, Jiangxi, China
                Author notes

                Edited by: Fabien Touzot, University of Montreal, Canada

                Reviewed by: Sadiq Umar, University of Illinois Chicago, United States

                Zhenhua Li, Brigham and Women’s Hospital and Harvard Medical School, United States

                *Correspondence: Shangzhi Feng, 1131718266@ 123456qq.com
                Article
                DOI: 10.3389/fimmu.2024.1364401
                PMC ID: 10965547
                PubMed ID: 38545101
                SO-VID: 97d92fad-6e19-4481-8478-9cdf2843f216
                Copyright © Copyright © 2024 Lou, Luo, Jiang and Feng
                License:

                This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

                History
                Date received : 02 January 2024
                Date accepted : 04 March 2024
                Page count
                Figures: 2, Tables: 1, Equations: 0, References: 153, Pages: 11, Words: 4687
                Funding
                The author(s) declare that no financial support was received for the research, authorship, and/or publication of this article.
                Categories
                Subject: Immunology
                Subject: Review
                Custom metadata
                section-in-acceptance Inflammation

                ScienceOpen disciplines: Immunology
                Keywords: extracellular vesicles,inflammatory,plant-derived evs,milk-derived evs,msc-derived evs,macrophage-derived evs
                Data availability:
                ScienceOpen disciplines: Immunology
                Keywords: extracellular vesicles, inflammatory, plant-derived evs, milk-derived evs, msc-derived evs, macrophage-derived evs

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