Journal ID (nlm-ta): PLoS Pathog
Journal ID (iso-abbrev): PLoS Pathog
Journal ID (publisher-id): plos
Journal ID (pmc): plospath
Title:
PLoS Pathogens
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Print):
1553-7366
ISSN
(Electronic):
1553-7374
Publication date
(Electronic):
14
September
2016
Publication date Collection:
September
2016
Volume: 12
Issue: 9
Electronic Location Identifier: e1005864
Affiliations
[1
]Department of Microbiology and Immunology, Weill Medical College of Cornell University,
New York, New York, United States of America
[2
]Department of Surgery, Duke University Medical Center, Durham, North Carolina, United
States of America
[3
]Department of Integrative Structural and Computational Biology, International AIDS
Vaccine Initiative (IAVI) Neutralizing Antibody Center and the Collaboration for AIDS
Vaccine Discovery (CAVD), The Scripps Research Institute, La Jolla, California, United
States of America
[4
]Department of Medical Microbiology, Academic Medical Center, University of Amsterdam,
Amsterdam, The Netherlands
[5
]Department of Medicinal Chemistry, University of Washington, Seattle, Washington,
United States of America
[6
]Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research
Institute, La Jolla, California, United States of America
[7
]The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla,
California, United States of America
Miller School of Medicine, UNITED STATES
Author notes
The authors have declared that no competing interests exist.
-
Conceived and designed the experiments: PJK IAW ABW STB RWS JPM.
-
Performed the experiments: CCL DCM TJK.
-
Analyzed the data: PJK DCM IAW ABW JPM.
-
Contributed reagents/materials/analysis tools: AC MGo RPR PP GO MJvG KKL MGu.
-
Wrote the paper: PJK DCM IAW ABW RWS JPM.
-
Funded and supervised the study: PJK KKL DCM IAW ABW STB RWS JPM.
Article
Publisher ID:
PPATHOGENS-D-16-01438
DOI: 10.1371/journal.ppat.1005864
PMC ID: 5023125
PubMed ID: 27627672
SO-VID: 978aceb1-e00a-490b-819b-ec2d574ed63a
Copyright © © 2016 Klasse et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
Funded by: funder-id http://dx.doi.org/10.13039/100000060, National Institute of Allergy and Infectious Diseases;
Award ID: AI082362
Award Recipient
:
John P. Moore
Funded by: funder-id http://dx.doi.org/10.13039/100000060, National Institute of Allergy and Infectious Diseases;
Award ID: AI110657
Award Recipient
:
John P. Moore
Funded by: funder-id http://dx.doi.org/10.13039/100000060, National Institute of Allergy and Infectious Diseases;
Award ID: AI36082
Award Recipient
:
John P. Moore
Funded by: funder-id http://dx.doi.org/10.13039/100000060, National Institute of Allergy and Infectious Diseases;
Award ID: R21 AI112389
Award Recipient
:
Kelly K. Lee
Funded by: funder-id http://dx.doi.org/10.13039/100000060, National Institute of Allergy and Infectious Diseases;
Award ID: 1UM1 AI100663
Funded by: funder-id http://dx.doi.org/10.13039/100000865, Bill and Melinda Gates Foundation;
Award ID: OPP1132237
Award Recipient
:
John P. Moore
The non-animal research was supported by NIH grants P01 AI082362 and P01 AI110657
(JPM, RWS, IAW, ABW, and PJK), R37 AI36082 (JPM and PJK), R21 AI112389 (KKL), and
the NIH-NIAID NHP Humoral Immunology Laboratory Contract HHSN27201100016C (DCM). The
animal studies were supported by the Bill and Melinda Gates Foundation grant OPP1132237
(JPM) and by NIH award 1UM1 AI100663 to the Scripps CHAVI-ID. RWS is a recipient of
a Vidi grant from the Netherlands Organization for Scientific Research (NWO) and a
Starting Investigator Grant from the European Research Council (ERC-StG-2011–280829-SHEV).
The websites of funders are:
https://www.nih.gov/;
www.gatesfoundation.org/;
www.nwo.nl/en; and
https://urldefense.proofpoint.com/v2/url?u=https-3A__erc.europa.eu_&d=DQIGaQ&c=lb62iw4YL4RFalcE2hQUQealT9-RXrryqt9KZX2qu2s&r=2N3t39aZ_4KEOrbiUwyFkPKri6222-E9wUuL6_nZopY&m=fSU92ENQQMj2OPa7ViZ5oYpgIHRKFn_UPliT6aadeD0&s=mhkiEPltQEqDCR1CCgeVAUNlvNNAvWo8IHkaKQvyAPU&e=. The funders had no role in study design, data collection and analysis, decision
to publish, or preparation of the manuscript.
Subject:
Research Article
Subject:
Research and Analysis Methods
Subject:
Model Organisms
Subject:
Animal Models
Subject:
Rabbits
Subject:
Biology and Life Sciences
Subject:
Organisms
Subject:
Animals
Subject:
Vertebrates
Subject:
Amniotes
Subject:
Mammals
Subject:
Rabbits
Subject:
Biology and Life Sciences
Subject:
Immunology
Subject:
Immune Response
Subject:
Medicine and Health Sciences
Subject:
Immunology
Subject:
Immune Response
Subject:
Biology and Life Sciences
Subject:
Physiology
Subject:
Immune Physiology
Subject:
Antigens
Subject:
Medicine and Health Sciences
Subject:
Physiology
Subject:
Immune Physiology
Subject:
Antigens
Subject:
Biology and Life Sciences
Subject:
Immunology
Subject:
Immune System Proteins
Subject:
Antigens
Subject:
Medicine and Health Sciences
Subject:
Immunology
Subject:
Immune System Proteins
Subject:
Antigens
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Proteins
Subject:
Immune System Proteins
Subject:
Antigens
Subject:
Biology and Life Sciences
Subject:
Physiology
Subject:
Immune Physiology
Subject:
Antibodies
Subject:
Medicine and Health Sciences
Subject:
Physiology
Subject:
Immune Physiology
Subject:
Antibodies
Subject:
Biology and Life Sciences
Subject:
Immunology
Subject:
Immune System Proteins
Subject:
Antibodies
Subject:
Medicine and Health Sciences
Subject:
Immunology
Subject:
Immune System Proteins
Subject:
Antibodies
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Proteins
Subject:
Immune System Proteins
Subject:
Antibodies
Subject:
Research and Analysis Methods
Subject:
Immunologic Techniques
Subject:
Immunoassays
Subject:
Enzyme-Linked Immunoassays
Subject:
Biology and Life Sciences
Subject:
Immunology
Subject:
Immune Response
Subject:
Antibody Response
Subject:
Medicine and Health Sciences
Subject:
Immunology
Subject:
Immune Response
Subject:
Antibody Response
Subject:
Biology and Life Sciences
Subject:
Molecular Biology
Subject:
Molecular Biology Techniques
Subject:
Cloning
Subject:
Research and Analysis Methods
Subject:
Molecular Biology Techniques
Subject:
Cloning
Subject:
Biology and Life Sciences
Subject:
Microbiology
Subject:
Medical Microbiology
Subject:
Microbial Pathogens
Subject:
Viral Pathogens
Subject:
Immunodeficiency Viruses
Subject:
HIV
Subject:
HIV-1
Subject:
Medicine and Health Sciences
Subject:
Pathology and Laboratory Medicine
Subject:
Pathogens
Subject:
Microbial Pathogens
Subject:
Viral Pathogens
Subject:
Immunodeficiency Viruses
Subject:
HIV
Subject:
HIV-1
Subject:
Biology and Life Sciences
Subject:
Organisms
Subject:
Viruses
Subject:
Viral Pathogens
Subject:
Immunodeficiency Viruses
Subject:
HIV
Subject:
HIV-1
Subject:
Biology and Life Sciences
Subject:
Organisms
Subject:
Viruses
Subject:
Immunodeficiency Viruses
Subject:
HIV
Subject:
HIV-1
Subject:
Biology and life sciences
Subject:
Organisms
Subject:
Viruses
Subject:
RNA viruses
Subject:
Retroviruses
Subject:
Lentivirus
Subject:
HIV
Subject:
HIV-1
Subject:
Biology and Life Sciences
Subject:
Microbiology
Subject:
Medical Microbiology
Subject:
Microbial Pathogens
Subject:
Viral Pathogens
Subject:
Retroviruses
Subject:
Lentivirus
Subject:
HIV
Subject:
HIV-1
Subject:
Medicine and Health Sciences
Subject:
Pathology and Laboratory Medicine
Subject:
Pathogens
Subject:
Microbial Pathogens
Subject:
Viral Pathogens
Subject:
Retroviruses
Subject:
Lentivirus
Subject:
HIV
Subject:
HIV-1
Subject:
Biology and Life Sciences
Subject:
Organisms
Subject:
Viruses
Subject:
Viral Pathogens
Subject:
Retroviruses
Subject:
Lentivirus
Subject:
HIV
Subject:
HIV-1