Discovery, research and development of axalion® active insecticide: dimpropyridaz ^†

Abstract

Dimpropyridaz is a novel insecticide active ingredient (a.i.) for the control of piercing and sucking pests. The discovery of dimpropyridaz included the synthesis of thousands of compound analogs which were investigated for their potential efficacy and registrability. Dimpropyridaz is the sole representative of the pyridazine pyrazolecarboxamide class, Insecticide Resistance Action Committee ( IRAC) Group 36. The novel mode of action is characterized by disrupting the function of an insect's chordotonal organs in a way that is distinctly different from IRAC Groups 9 and 29. Dimpropyridaz demonstrates translaminar and systemic effects as well as high selectivity, providing both application flexibility and, when applied according to the label, beneficial organism, and environmental compatibility. Dimpropyridaz, powered formulations will be available in select markets, covering a broad range of vegetable, fruit, row crop, and ornamental production segments. Dimpropyridaz also has commercial registered name: Axalion Active. This review will focus on a broad outline of the chemical preparation, regulatory overview, and select biological performance and represents a summary of the information shared during the invited lecture at the 15th IUPAC (International Union of Pure and Applied Chemistry) International Congress of Crop Protection Chemistry held in New Delhi, India in March 2023. © 2024 BASF. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.