The odontoblastic differentiation of dental mesenchymal stem cells: molecular regulation mechanism and related genetic syndromes

Author(s): Houwen Pan ¹ ^, ² ^, ³ ^, ⁴ ^, ⁵ ^, ⁶ , Yiling Yang ¹ ^, ² ^, ³ ^, ⁴ ^, ⁵ ^, ⁶ , Hongyuan Xu ¹ ^, ² ^, ³ ^, ⁴ ^, ⁵ ^, ⁶ , Anting Jin ¹ ^, ² ^, ³ ^, ⁴ ^, ⁵ ^, ⁶ , Xiangru Huang ¹ ^, ² ^, ³ ^, ⁴ ^, ⁵ ^, ⁶ , Xin Gao ¹ ^, ² ^, ³ ^, ⁴ ^, ⁵ ^, ⁶ , Siyuan Sun ¹ ^, ² ^, ³ ^, ⁴ ^, ⁵ ^, ⁶ , Yuanqi Liu ¹ ^, ² ^, ³ ^, ⁴ ^, ⁵ ^, ⁶ , Jingyi Liu ¹ ^, ² ^, ³ ^, ⁴ ^, ⁵ ^, ⁶ , Tingwei Lu ¹ ^, ² ^, ³ ^, ⁴ ^, ⁵ ^, ⁶ , Xinyu Wang ¹ ^, ² ^, ³ ^, ⁴ ^, ⁵ ^, ⁶ , Yanfei Zhu ¹ ^, ² ^, ³ ^, ⁴ ^, ⁵ ^, ⁶ ^, ^* ^, , Lingyong Jiang ¹ ^, ² ^, ³ ^, ⁴ ^, ⁵ ^, ⁶ ^, ^* ^,

Publication date (Electronic): 25 September 2023

Journal: Frontiers in Cell and Developmental Biology

Publisher: Frontiers Media S.A.

Keywords: odontoblastic differentiation, dental mesenchymal stem cells, molecular regulation, signaling pathway, genetic syndrome

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Abstract

Dental mesenchymal stem cells (DMSCs) are multipotent progenitor cells that can differentiate into multiple lineages including odontoblasts, osteoblasts, chondrocytes, neural cells, myocytes, cardiomyocytes, adipocytes, endothelial cells, melanocytes, and hepatocytes. Odontoblastic differentiation of DMSCs is pivotal in dentinogenesis, a delicate and dynamic process regulated at the molecular level by signaling pathways, transcription factors, and posttranscriptional and epigenetic regulation. Mutations or dysregulation of related genes may contribute to genetic diseases with dentin defects caused by impaired odontoblastic differentiation, including tricho-dento-osseous (TDO) syndrome, X-linked hypophosphatemic rickets (XLH), Raine syndrome (RS), hypophosphatasia (HPP), Schimke immuno-osseous dysplasia (SIOD), and Elsahy-Waters syndrome (EWS). Herein, recent progress in the molecular regulation of the odontoblastic differentiation of DMSCs is summarized. In addition, genetic syndromes associated with disorders of odontoblastic differentiation of DMSCs are discussed. An improved understanding of the molecular regulation and related genetic syndromes may help clinicians better understand the etiology and pathogenesis of dentin lesions in systematic diseases and identify novel treatment targets.

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Functional Classification and Experimental Dissection of Long Noncoding RNAs

Florian Kopp, Joshua Mendell (2018)

Over the last decade, it has been increasingly demonstrated that the genomes of many species are pervasively transcribed, resulting in the production of numerous long noncoding RNAs (lncRNAs). At the same time, it is now appreciated that many types of DNA regulatory elements, such as enhancers and promoters, regularly initiate bidirectional transcription. Thus, discerning functional noncoding transcripts from a vast transcriptome is a paramount priority, and challenge, for the lncRNA field. In this review, we aim to provide a conceptual and experimental framework for classifying and elucidating lncRNA function. We categorize lncRNA loci into those that regulate gene expression in cis versus those that perform functions in trans , and propose an experimental approach to dissect lncRNA activity based on these classifications. These strategies to further understand lncRNAs promise to reveal new and unanticipated biology, with great potential to advance our understanding of normal physiology and disease.

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Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities.

Roel Nusse, Hans Clevers (2017)

The WNT signal transduction cascade is a main regulator of development throughout the animal kingdom. Wnts are also key drivers of most types of tissue stem cells in adult mammals. Unsurprisingly, mutated Wnt pathway components are causative to multiple growth-related pathologies and to cancer. Here, we describe the core Wnt/β-catenin signaling pathway, how it controls stem cells, and contributes to disease. Finally, we discuss strategies for Wnt-based therapies.

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The functions of animal microRNAs.

Victor Ambros (2004)

MicroRNAs (miRNAs) are small RNAs that regulate the expression of complementary messenger RNAs. Hundreds of miRNA genes have been found in diverse animals, and many of these are phylogenetically conserved. With miRNA roles identified in developmental timing, cell death, cell proliferation, haematopoiesis and patterning of the nervous system, evidence is mounting that animal miRNAs are more numerous, and their regulatory impact more pervasive, than was previously suspected.

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Author and article information

Contributors

Houwen Pan: URI : https://loop.frontiersin.org/people/2132713/overview

Siyuan Sun: URI : https://loop.frontiersin.org/people/673663/overview

Yanfei Zhu: URI : https://loop.frontiersin.org/people/2224398/overview

Journal

Journal ID (nlm-ta): Front Cell Dev Biol

Journal ID (iso-abbrev): Front Cell Dev Biol

Journal ID (publisher-id): Front. Cell Dev. Biol.

Title: Frontiers in Cell and Developmental Biology

Publisher: Frontiers Media S.A.

ISSN (Electronic): 2296-634X

Publication date (Electronic): 25 September 2023

Publication date Collection: 2023

Volume: 11

Electronic Location Identifier: 1174579

Affiliations

[1] ¹ Center of Craniofacial Orthodontics, Department of Oral and Cranio-Maxillofacial Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai, China

[2] ² College of Stomatology, Shanghai Jiao Tong University , Shanghai, China

[3] ³ National Center for Stomatology , Shanghai, China

[4] ⁴ National Clinical Research Center for Oral Disease , Shanghai, China

[5] ⁵ Shanghai Key Laboratory of Stomatology , Shanghai, China

[6] ⁶ Shanghai Research Institute of Stomatology , Shanghai, China

Author notes

Edited by: Guohua Yuan, Wuhan University, China

Reviewed by: Yuji Mishina, University of Michigan, United States

Kyoko Oka, Fukuoka Dental College, Japan

*Correspondence: Lingyong Jiang, jianglingyong@ 123456sjtu.edu.cn ; Yanfei Zhu, 846248754@ 123456qq.com

Article

Publisher ID: 1174579

DOI: 10.3389/fcell.2023.1174579

PMC ID: 10561098

PubMed ID: 37818127

SO-VID: 97005321-6e0c-4593-b8a6-ed5a8a993057

License:

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

History

Date received : 26 February 2023

Date accepted : 24 August 2023

Funding

This work was supported in part by grants from Fund of Department of Oral and Maxillofacial Surgery (Xi 2022-05); the Interdisciplinary Program of Shanghai Jiao Tong University (YG2023ZD14); the Fundamental Research Funds for the Central Universities; the National Natural Science Foundation of China (82271006, 82101048, 82071083, 81870740, and 81570950); the Natural Science Foundation of Shanghai (21ZR1436900 and 22ZR1436700); the Program of Shanghai Academic/Technology Research Leader (20XD1422300); Clinical Research Plan of SHDC (SHDC2020CR4084); the Cross-disciplinary Research Fund of Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine (JYJC201902 and JYJC202116); the Innovation Research Team of High-Level Local Universities in Shanghai (SSMUZLCX20180501); the Research Discipline Fund No. KQYJXK2020 from Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, and College of Stomatology, Shanghai Jiao Tong University; Original Exploration Project of Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine (JYYC003); Two-Hundred Talent Project of Shanghai Jiao Tong University School of Medicine; the Biomaterials and Regenerative Medicine Institute Cooperative Research Project Shanghai Jiao Tong University School of Medicine (2022LHB02); the Project of Biobank of Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine (YBKB201909, YBKB202216); Joint Research Project of Institute of Biomaterials and Regenerative Medicine, Shanghai Jiao Tong University School of Medicine (2022LHB02).

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section-at-acceptance Stem Cell Research

Keywords: odontoblastic differentiation,dental mesenchymal stem cells,molecular regulation,signaling pathway,genetic syndrome

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Keywords: odontoblastic differentiation, dental mesenchymal stem cells, molecular regulation, signaling pathway, genetic syndrome

The odontoblastic differentiation of dental mesenchymal stem cells: molecular regulation mechanism and related genetic syndromes

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Abstract

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Most cited references 260

Functional Classification and Experimental Dissection of Long Noncoding RNAs

Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities.

The functions of animal microRNAs.

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