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Abstract
Recent studies have highlighted important roles for long noncoding RNAs (lncRNAs)
during the complex process of carcinogenesis. H19 is an example of an lncRNA that
can function either as a tumor promoter or a tumor suppressor. Here, we investigated
the role of H19 in papillary thyroid carcinoma (PTC). First, we assessed H19 expression
levels in human PTC tissues and PTC cell lines using quantitative real-time PCR. We
also established H19-overexpressed PTC cell lines with lentiviral vectors to investigate
the effects of H19 on the proliferation and migration of PTC cells. Our results suggest
that H19 is downregulated in PTC tissues and in PTC cell lines compared to controls.
Decreased H19 expression was correlated with lymph node metastasis. H19 overexpression
reduced PTC cell proliferation and migration. It also inhibited the expression of
tumor necrosis factor receptor 2. These results suggest that H19 inhibits tumorigenesis
in PTC and may be utilized as a potential diagnostic tool for PTC.