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      Crosstalk between Interleukin-1β and Type I Interferons Signaling in Autoinflammatory Diseases

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      Author(s):
      Editor(s): ,
      Publication date (Electronic):
      Journal: Cells
      Publisher: MDPI
      Keywords: inflammation, type I interferons, interleukin-1β, crosstalk

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          Abstract

          Interleukin-1β (IL-1β) and type I interferons (IFNs) are major cytokines involved in autoinflammatory/autoimmune diseases. Separately, the overproduction of each of these cytokines is well described and constitutes the hallmark of inflammasomopathies and interferonopathies, respectively. While their interaction and the crosstalk between their downstream signaling pathways has been mostly investigated in the frame of infectious diseases, little information on their interconnection is still available in the context of autoinflammation promoted by sterile triggers. In this review, we will examine the respective roles of IL-1β and type I IFNs in autoinflammatory/rheumatic diseases and analyze their potential connections in the pathophysiology of some of these diseases, which could reveal novel therapeutic opportunities.

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          DAMP-sensing receptors in sterile inflammation and inflammatory diseases

          Tao Gong, Lei Liu, Wei Jiang … (2019)
          The innate immune system has the capacity to detect 'non-self' molecules derived from pathogens, known as pathogen-associated molecular patterns, via pattern recognition receptors. In addition, an increasing number of endogenous host-derived molecules, termed damage-associated molecular patterns (DAMPs), have been found to be sensed by various innate immune receptors. The recognition of DAMPs, which are produced or released by damaged and dying cells, promotes sterile inflammation, which is important for tissue repair and regeneration, but can also lead to the development of numerous inflammatory diseases, such as metabolic disorders, neurodegenerative diseases, autoimmune diseases and cancer. Here we examine recent discoveries concerning the roles of DAMP-sensing receptors in sterile inflammation and in diseases resulting from dysregulated sterile inflammation, and then discuss insights into the cross-regulation of these receptors and their ligands.
          Article 0 comments Cited 640 times – based on 0 reviews     Review now
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            Shared and Distinct Functions of Type I and Type III Interferons

            Helen M. Lazear, John W Schoggins, Michael S. Diamond (2019)
            Type I interferons (IFNs) (IFN-α, IFN-β) and type III IFNs (IFN-λ) share many properties, including induction by viral infection, activation of shared signaling pathways, and transcriptional programs. However, recent discoveries have revealed context-specific functional differences. Here, we provide a comprehensive review of type I and type III IFN activities, highlighting shared and distinct features from molecular mechanisms through physiological responses. Beyond discussing canonical antiviral functions, we consider the adaptive immune priming, anti-tumor, and autoimmune functions of IFNs. We discuss a model wherein type III IFNs serve as a front-line defense that controls infection at epithelial barriers while minimizing damaging inflammatory responses, reserving the more potent type I IFN response for when local responses are insufficient. In this context, we discuss current therapeutic applications targeting these cytokine pathways and highlight gaps in understanding of the biology of type I and type III IFNs in health and disease.
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              Trial of Anifrolumab in Active Systemic Lupus Erythematosus

              Eric F Morand, Richard Furie, Yoshiya Tanaka … (2020)
              Anifrolumab, a human monoclonal antibody to type I interferon receptor subunit 1 investigated for the treatment of systemic lupus erythematosus (SLE), did not have a significant effect on the primary end point in a previous phase 3 trial. The current phase 3 trial used a secondary end point from that trial as the primary end point.
              Article 0 comments Cited 426 times – based on 0 reviews     Review now
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                Author and article information

                Contributors
                Silvia Fischer: Role: Academic Editor
                Elisabeth Deindl: Role: Academic Editor
                Journal
                Journal ID (nlm-ta): Cells
                Journal ID (iso-abbrev): Cells
                Journal ID (publisher-id): cells
                Title: Cells
                Publisher: MDPI
                ISSN (Electronic): 2073-4409
                Publication date (Electronic): 08 May 2021
                Publication date Collection: May 2021
                Volume: 10
                Issue: 5
                Electronic Location Identifier: 1134
                Affiliations
                Laboratoire d’ImmunoRhumatologie Moléculaire, Institut National de la Santé et de la Recherche Médicale (INSERM) UMR_S 1109, Institut Thématique Interdisciplinaire (ITI) de Médecine de Précision de Strasbourg, Transplantex NG, Faculté de Médecine, Fédération Hospitalo-Universitaire OMICARE, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de Strasbourg, 67085 Strasbourg, France; pgeorgel@ 123456unistra.fr
                Author information
                https://orcid.org/0000-0001-6853-7080
                Article
                Publisher ID: cells-10-01134
                DOI: 10.3390/cells10051134
                PMC ID: 8150590
                PubMed ID: 34066649
                SO-VID: 9684ddd7-b4f8-4199-938b-813fdaa2b228
                Copyright © © 2021 by the author.
                License:

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( https://creativecommons.org/licenses/by/4.0/).

                History
                Date received : 28 March 2021
                Date accepted : 06 May 2021
                Categories
                Subject: Review

                Keywords: inflammation,type i interferons,interleukin-1β,crosstalk
                Data availability:
                Keywords: inflammation, type i interferons, interleukin-1β, crosstalk

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