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Abstract
The major human rhinovirus receptor has been identified with monoclonal antibodies
that inhibit rhinovirus infection. These monoclonal antibodies recognize a 95 kd cell
surface glycoprotein on human cells and on mouse transfectants expressing a rhinovirus
binding phenotype. Purified 95 kd protein binds to rhinovirus in vitro. Protein sequence
from the 95 kd protein showed an identity with that of intercellular adhesion molecule-1
(ICAM-1); a cDNA clone obtained from mouse transfectants expressing the rhinovirus
receptor had essentially the same sequence as ICAM-1. Thus, the major human rhinovirus
receptor is ICAM-1. The gene for this receptor maps to human chromosome 19, which
also contains the genes for a number of other picornavirus receptors.