Fast whole brain MR imaging of dynamic susceptibility contrast changes in the cerebrospinal fluid (cDSC MRI).

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Abstract

The circulation of cerebrospinal fluid (CSF) is closely associated with many aspects of brain physiology. When gadolinium(Gd)-based contrast is administered intravenously, pre- and post-contrast MR signal changes can often be observed in the CSF at certain locations within the intra-cranial space, mainly due to the lack of a blood-brain barrier in the dural blood vessels. This study aims to develop and systemically optimize MRI sequences that can detect dynamic signal changes in the CSF after Gd administration with a sub-millimeter spatial resolution, a temporal resolution of <10 s, and whole brain coverage.

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Author and article information

Journal

Journal ID (iso-abbrev): Magn Reson Med

Title: Magnetic resonance in medicine

Publisher: Wiley

ISSN (Electronic): 1522-2594

ISSN (Print): 0740-3194

Publication date (Electronic): December 2020

Volume: 84

Issue: 6

Affiliations

[1 ] F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland, USA.

[2 ] Neurosection, Division of MRI Research, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

[3 ] Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, USA.

[4 ] Division of Neuroradiology, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

[5 ] Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Article

Mid ID: NIHMS1689762

DOI: 10.1002/mrm.28389

PMC ID: 8113983

PubMed ID: 32621291

SO-VID: 95dd9b07-a771-4ef5-9ce9-90b47313235b

History

Keywords: CSF,ISF,MRI,contrast,gadolinium,lymphatic

Data availability:

Keywords: CSF, ISF, MRI, contrast, gadolinium, lymphatic

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