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      Cardiovascular and haematological events post COVID‐19 vaccination: A systematic review

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          Abstract

          Since COVID‐19 took a strong hold around the globe causing considerable morbidity and mortality, a lot of effort was dedicated to manufacturing effective vaccines against SARS‐CoV‐2. Many questions have since been raised surrounding the safety of the vaccines, and a lot of media attention to certain side effects. This caused a state of vaccine hesitancy that may prove problematic in the global effort to control the virus. This review was undertaken with the aim of putting together all the reported cardiovascular and haematological events post COVID‐19 vaccination in published literature and to suggest possible mechanisms to explain these rare phenomena.

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          Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement.

          David Moher, Alessandro Liberati, Jennifer Tetzlaff … (2010)
          Article 0 comments Cited 2318 times – based on 0 reviews     Review now
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            Association of Cardiac Injury With Mortality in Hospitalized Patients With COVID-19 in Wuhan, China

            Shaobo Shi, Mu Qin, Bo Shen … (2020)
            Coronavirus disease 2019 (COVID-19) has resulted in considerable morbidity and mortality worldwide since December 2019. However, information on cardiac injury in patients affected by COVID-19 is limited.
            Article 0 comments Cited 2180 times – based on 0 reviews     Review now
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              mRNA vaccines — a new era in vaccinology

              Norbert Pardi, Michael Hogan, Frederick W. Porter … (2018)
              mRNA vaccines represent a promising alternative to conventional vaccine approaches because of their high potency, capacity for rapid development and potential for low-cost manufacture and safe administration. However, their application has until recently been restricted by the instability and inefficient in vivo delivery of mRNA. Recent technological advances have now largely overcome these issues, and multiple mRNA vaccine platforms against infectious diseases and several types of cancer have demonstrated encouraging results in both animal models and humans. This Review provides a detailed overview of mRNA vaccines and considers future directions and challenges in advancing this promising vaccine platform to widespread therapeutic use.
              Article 0 comments Cited 1611 times – based on 0 reviews     Review now
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                Author and article information

                Contributors
                Pradipta Paul:
                ORCID: https://orcid.org/0000-0001-6283-1596
                prp4005@qatar-med.cornell.edu
                Dalia Zakaria:
                ORCID: https://orcid.org/0000-0001-9020-0038
                dez2003@qatar-med.cornell.edu
                Journal
                Journal ID (nlm-ta): J Cell Mol Med
                Journal ID (iso-abbrev): J Cell Mol Med
                Journal ID (doi): 10.1111/(ISSN)1582-4934
                Journal ID (publisher-id): JCMM
                Title: Journal of Cellular and Molecular Medicine
                Publisher: John Wiley and Sons Inc. (Hoboken )
                ISSN (Print): 1582-1838
                ISSN (Electronic): 1582-4934
                Publication date (Electronic): 29 December 2021
                Publication date (Print): February 2022
                Volume: 26
                Issue: 3 ( doiID: 10.1111/jcmm.v26.3 )
                Pages: 636-653
                Affiliations
                [ 1 ] Weill Cornell Medicine Qatar Doha Qatar
                [ 2 ] Department of Cardiovascular Medicine Cleveland Clinic Cleveland Ohio USA
                Author notes
                [*] [* ] Correspondence

                Dalia Zakaria, Weill Cornell Medicine Qatar, Qatar Foundation, Education City, Al Luqta St. Ar‐Rayyan, P.O. Box 24144, Doha, Qatar.

                Email: dez2003@ 123456qatar-med.cornell.edu

                Author information
                https://orcid.org/0000-0003-1170-6722
                https://orcid.org/0000-0001-7128-2701
                https://orcid.org/0000-0002-8243-7438
                https://orcid.org/0000-0001-6283-1596
                https://orcid.org/0000-0001-9020-0038
                Article
                Publisher ID: JCMM17137
                DOI: 10.1111/jcmm.17137
                PMC ID: 8817142
                PubMed ID: 34967105
                SO-VID: 951678d0-cf77-4f15-9c3c-94db7178615b
                Copyright © © 2021 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.
                License:

                This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

                History
                Date revision received : 05 December 2021
                Date received : 26 September 2021
                Date accepted : 09 December 2021
                Page count
                Figures: 7, Tables: 0, Pages: 18, Words: 14189
                Funding
                Funded by: Qatar National Library
                Categories
                Subject: Review
                Subject: Reviews
                Custom metadata
                source-schema-version-number 2.0
                cover-date February 2022
                details-of-publishers-convertor Converter:WILEY_ML3GV2_TO_JATSPMC version:6.1.1 mode:remove_FC converted:05.02.2022

                ScienceOpen disciplines: Molecular medicine
                Keywords: covid‐19,haemorrhage,myocardial infraction,myocarditis,myopericarditis,pericarditis,thrombocytopenia,thrombosis,vaccine
                Data availability:
                ScienceOpen disciplines: Molecular medicine
                Keywords: covid‐19, haemorrhage, myocardial infraction, myocarditis, myopericarditis, pericarditis, thrombocytopenia, thrombosis, vaccine

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