Controlling Shear Stress in 3D Bioprinting is a Key Factor to Balance Printing Resolution and Stem Cell Integrity.

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Abstract

A microvalve-based bioprinting system for the manufacturing of high-resolution, multimaterial 3D-structures is reported. Applying a straightforward fluid-dynamics model, the shear stress at the nozzle site can precisely be controlled. Using this system, a broad study on how cell viability and proliferation potential are affected by different levels of shear stress is conducted. Complex, multimaterial 3D structures are printed with high resolution. This work pioneers the investigation of shear stress-induced cell damage in 3D bioprinting and might help to comprehend and improve the outcome of cell-printing studies in the future.

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Author and article information

Journal

Journal ID (iso-abbrev): Adv Healthc Mater

Title: Advanced healthcare materials

Publisher: Wiley-Blackwell

ISSN (Electronic): 2192-2659

ISSN (Print): 2192-2640

Publication date (Electronic): Feb 04 2016

Volume: 5

Issue: 3

Affiliations

[1 ] Department of Dental Materials and Biomaterials Research, RWTH Aachen University Hospital, Pauwelsstrasse 30, 52074, Aachen, Germany.

[2 ] Institute of Physical Chemistry, RWTH Aachen University, Landoltweg 2, 52074, Aachen, Germany.

[3 ] Department of Materials, Department of Bioengineering and Institute of Biomedical Engineering, Imperial College London, London SW7 2AZ, London, UK.

Article

DOI: 10.1002/adhm.201500677

PubMed ID: 26626828

SO-VID: 950fe2a9-dd47-49f8-9ec4-d44129b45e76

History

Keywords: stem cells,shear stress,rheology,hydrogels,bioprinting

Data availability:

Keywords: stem cells, shear stress, rheology, hydrogels, bioprinting

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