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      Sarcoidose et spondylarthrite ankylosante: une association rare Translated title: Sarcoidosis and ankylosing spondylitis: a rare association

      case-report

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          Abstract

          L’association spondylarthrite ankylosante et sarcoïdose est rare, seize cas ont été publiés dans la littérature, nous en rapportons un nouveau cas. Cette association qui pose des problèmes diagnostiques est probablement fortuite du fait de l’absence de facteurs génétiques prédisposant partagés et du petit nombre des cas publiés, mais elle suggère l’hypothèse d’une liaison physiopathologique entre eux.

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          An assessment of back pain and the prevalence of sacroiliitis in sarcoidosis.

          George Kitas, R Shave, M Cushley … (2004)
          Sarcoidosis is a chronic granulomatous multisystem disease in which arthritis is relatively common. Arthritis of the sacroiliac joints (sacroiliitis) has been described in sarcoidosis but is thought to be rare. The objective of this study was to determine the prevalence of sacroiliitis in a secondary-care population of patients with sarcoidosis. Patients attending a specialist secondary-care sarcoidosis clinic underwent evaluation of spinal symptoms using a standard back pain questionnaire, examination of spinal mobility, and laboratory measurements of erythrocyte sedimentation rate, C-reactive protein, serum angiotensin-converting enzyme, and neopterin/creatinine ratio. Tissue typing for the presence of the human leukocyte antigen (HLA)-B27 allele was undertaken. Radiographs of the sacroiliac joints were obtained in each patient and reviewed independently by two observers; a further observer reviewed disputed radiographs. Sixty-one patients completed the assessments (80.3% of all patients invited to participate). Forty-nine of 61 patients (80.3%) reported having back pain at some point in their lives. Thirty-one of 61 patients (50.8%) had a score on the back pain questionnaire suggestive of inflammatory spinal disease, but only 3 of these patients had erosive damage of the sacroiliac joints on radiography indicating sacroiliitis. One further patient had erosive damage on radiography, making a total of four individuals with evidence of sacroiliitis, a prevalence of 6.6%. Four patients (one patient with sacroiliitis) were positive for HLA-B27. The back pain questionnaire had a sensitivity of 75% and a specificity of 51% for sacroiliitis in this population. The prevalence of spondyloarthropathy in the normal population has been estimated to be 1.9%. In the sarcoid population studied the prevalence was 6.6% suggesting a possible association between these two conditions. The standard back pain questionnaire for the identification of inflammatory spinal disease had a low sensitivity and specificity in this population.
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            A co-occurrence of sarcoidosis and ankylosing spondylitis: a case report.

            H Cay, Hilal Kocabas, C Kaçar … (2008)
            Sarcoidosis is an inflammatory multi-system disease, which may cause articular involvement. By causing sacroiliitis, it may mimic spondyloarthropathies. A case with a co-occurrence of sarcoidosis and late-onset of typical ankylosing spondylitis was presented and a possible association between these two entities was discussed.
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              Ankylosing spondylitis and sarcoidosis--coincidence or association? Case report and review of the literature.

              R Speich, G. Stucki, Andrea von Berg … (1992)
              We report a 25-year-old woman presenting with sarcoidosis and bilateral sacroiliitis. Her sarcoidosis related symptoms (malaise, cough and dyspnoea) improved dramatically under treatment with steroids but severe back pain persisted. Only seven similar cases have been described over the last 40 years and the question of a possible association between the two diseases has been raised. However, prevalence data from the literature and the apparent lack of genetic links are better arguments for coincidence than for association.
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                Author and article information

                Journal
                Journal ID (nlm-ta): Pan Afr Med J
                Journal ID (publisher-id): pamj
                Title: The Pan African Medical Journal
                Publisher: African Field Epidemiology Network
                ISSN (Electronic): 1937-8688
                Publication date Collection: 2011
                Publication date (Electronic): 14 March 2011
                Volume: 8
                Electronic Location Identifier: 23
                Affiliations
                [1 ]Service de Rhumatologie, CHU Hassan II, Fès, Maroc
                Author notes
                [& ]Corresponding author: Fatima Zahra El Ouazzani, Service de Rhumatologie, CHU Hassan II, Fès, Maroc
                Article
                PMC ID: 3201588
                PubMed ID: 22121432
                SO-VID: 94d713e5-bcdc-4b1f-833b-e92422b77abb
                Copyright © © Fatima Zahra El Ouazzani et al.
                License:

                The Pan African Medical Journal - ISSN 1937-8688. This is an Open Access article distributed under the terms of the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                Date received : 18 December 2010
                Date accepted : 09 March 2011
                Categories
                Subject: Case Report
                Subject: Epidemiology/Public Health

                ScienceOpen disciplines: Medicine
                Keywords: spondylarthrite ankylosante,sarcoïdose,sacro-iliite,hla b27,spondylarthropathie
                Data availability:
                ScienceOpen disciplines: Medicine
                Keywords: spondylarthrite ankylosante, sarcoïdose, sacro-iliite, hla b27, spondylarthropathie

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