Human rabies deaths are preventable through prompt administration of postexposure
prophylaxis (PEP) with rabies immune globulin and rabies vaccine after exposure to
a rabid animal (
1
); there are no known contraindications to receiving PEP (
1
,
2
). Despite widespread availability of PEP in Vietnam, in 2015 the Ministry of Health
(MoH) received reports of pregnant and breastfeeding women with clinically diagnosed
rabies. MoH investigated factors associated with these rabies cases. MoH found that,
during 2015–2016, among 169 cases reported in Vietnam, two probable cases of rabies
were reported in breastfeeding mothers and four in pregnant women, all of whom had
been bitten by dogs. All six patients died. Three of the four pregnant women had cesarean
deliveries. One of the three newborns died from complications believed to be unrelated
to rabies; the fourth pregnant woman contracted rabies too early in pregnancy for
the fetus to be viable. Two of the patients sought care from a medical provider or
traditional healer; however, none sought PEP after being bitten. In each case, families
reported the patient’s fear of risk to the fetus or breastfed child as the primary
barrier to receiving PEP. These findings highlight the need for public health messaging
about the safety and effectiveness of PEP in preventing rabies among all persons with
exposures, including pregnant and breastfeeding women.
Investigation and Results
Human rabies cases are reportable to MoH in Vietnam within 48 hours after clinical
diagnosis, based on the World Health Organization’s probable case definition* (
1
). Probable cases of human rabies are investigated by MoH staff members from the National
Rabies Control Program, using a standardized form to collect information on demographics,
exposure, clinical symptoms, treatment, barriers to receipt of PEP, and outcomes.
Although confirmatory laboratory testing is available, for various reasons including
cultural barriers, hesitation by medical providers to collect specimens, and the cost
of shipping specimens to the national laboratory, very few specimens are collected
(
3
). Vietnam is committed to increasing accessibility of PEP throughout the country.
Bite victims can receive care at any district or provincial medical center but are
responsible for PEP-associated costs (approximately $153 USD for a full course, about
equal to the average monthly salary in Vietnam) (
3
).
To assess risk factors for not receiving rabies PEP, investigation forms for probable
rabies cases identified during 2015–2016 were reviewed. To evaluate the accessibility
of PEP to the six pregnant or breastfeeding women with rabies, the distance and estimated
travel time by automobile or motorized scooter (the primary mode of transportation)
to district and provincial-level medical centers from the homes of the six patients
were measured. The median age of the six pregnant or breastfeeding women with rabies
was 27 years (range = 19–33 years), and all patients had attended at least junior
high school (Table). The mean incubation period (from dog exposure to symptom onset)
was 85 days (range = 49–126 days). The median interval from symptom onset to death
was 2 days (range = 1–4 days).
TABLE
Selected characteristics, animal exposure, signs and symptoms, and treatment for six
fatal rabies cases in pregnant and breastfeeding women — Vietnam 2015–2016
Characteristic
No.
Education
Junior high school
5
Senior high school
1
Dog bite
6
Status of dog at time of patient exposure
Normal*
2
Stray
3
Ill
1
Dog rabies vaccination status
Yes
0
No
2
Unknown
4
Bite location
Foot or leg
5
Hand or arm
1
Rabies signs and symptoms†
Aerophobia (sensitivity to movement of air)
6
Anorexia
3
Anxiety
2
Fever
4
Headache
5
Hydrophobia
4
Insomnia
3
Malaise or fatigue
5
Muscle pain or spams
3
Paresthesia or localized pain
2
Wound treatment
None
2
At home
2
Medical center
1
Traditional healer
1
Received any postexposure prophylaxis
0
* Family reported that the dog appeared normal at the time of exposure. No information
was available regarding the status of the dog after 10 days.
† Patients could have multiple symptoms.
The six patients resided in four of Vietnam’s 63 provinces and major cities. The patients
exhibited classic signs and symptoms of rabies, including aerophobia (sensitivity
to air movement) (six patients), fever (four), and hydrophobia (four). Because of
cultural practices, laboratory confirmation was not available for any of the patients.
Four patients were pregnant at the time of rabies exposure, including three whose
pregnancies were at 32–37 weeks’ gestation at the time of symptom onset, prompting
emergency cesarean delivery. Two neonates survived, and the third died shortly after
delivery from complications believed to be unrelated to rabies. The fourth pregnant
patient developed rabies at approximately 18 weeks’ gestation; therefore, her fetus
could not be saved.
Two other patients were breastfeeding children aged <1 year at the time of rabies
exposure. Family members reported that mothers expressed concern about the possibility
of PEP being transferred to their children through breast milk, fearing that the antibodies
could harm the children because of their young age. Ten household contacts, including
husbands of the six patients, the two children of the breastfeeding mothers, and two
surviving neonates received PEP. All patients were reported to have been aware of
both rabies and PEP, but none sought PEP.
Family members reported that the pregnant women were concerned about potential risks
to their fetus. Only one patient, a breastfeeding mother, sought medical care after
an exposure (Table), but she declined PEP after receiving wound treatment for multiple
severe bites to her hand and arm by a stray dog. One of the pregnant patients was
reported to have sought care from a traditional healer after being bitten twice on
the leg by a stray dog. Family members reported that she had believed that treatment
from a traditional healer was safer than PEP. Among the four other bite victims, one
treated her wound at home with water, one with water and soap, and two did not treat
their bite wound.
None of the family members reported cost or transportation as a specific deterrent
to receiving PEP. The average distance from the patients’ homes to the provincial
medical center where PEP was available was 32.6 miles (range = 9.7–76.4 miles) (52.4
km [range = 15.6–123.0 km]) and time to travel was 78.5 minutes (range = 23–173 minutes).
The average distance to the district medical center where rabies vaccine (but not
rabies immune globulin) was available was 9.8 miles (range = 3.2–18.7 miles) (15.8
km [range = 5.1–30.1 km]), with a travel time of 30.7 minutes (range = 11–65 minutes).
Discussion
Most of the world’s estimated 60,000 annual rabies deaths occur in countries where
canine rabies is endemic and where PEP is often inaccessible to bite victims (
4
). When PEP is available, documentation of vaccination hesitancy for prevention of
rabies is rare. This investigation identified six rabies deaths among breastfeeding
or pregnant women. Based on information provided by family members, these deaths might
have been associated with unfounded concerns about vaccine-associated risks to the
fetus or breastfed child. A previous U.S. report also documented refusal to receive
PEP by a pregnant woman with a potential rabies exposure because of concerns about
the effect of PEP in the fetus; that patient did not develop rabies (
5
). Studies have found no increased risk for spontaneous abortions, premature births,
or fetal abnormalities among pregnant women after receiving PEP (
2
,
6
,
7
).
A growing body of literature documents peripartum rabies cases. Including the six
cases reported here, case reports and a literature review found 20 documented probable
or suspected peripartum rabies cases reported during the 114-year period, 1902–2016
(
8
,
9
). A total of 17 neonates survived, and were reported to be healthy, including eight
who did not receive vaccine or immunoglobulin after caesarean or vaginal delivery
(
8
). Among the three neonates who did not survive, one acquired rabies, and the other
two died from complications unrelated to rabies (
8
,
10
).
Vietnam has made progress in reducing human rabies deaths. The number of human rabies
cases declined 82%, from 505 cases in 1994 to 91 in 2016 (
3
). The expansion of PEP centers in the country has played a critical role in this
reduction by increasing access to PEP. National PEP surveillance data indicate that
an average of 400,000 vaccine doses are administered and 32,000 persons receive rabies
immune globulin each year (
3
). However, work is needed to understand and address the barriers to rabies treatment
among pregnant and breastfeeding women. In this investigation, only one of the six
pregnant or breastfeeding bite victims sought medical care after an exposure.
One strategy aimed at improving health care–seeking behavior and PEP acceptance is
training village health workers to educate community members, including pregnant and
breastfeeding women, regarding treatment options for rabies and the safety of PEP.
Village health workers are respected in the community and are often sought for health
advice on matters including prenatal nutrition and childhood illness. These health
workers could also alert health authorities about animal exposures, prompting a community
investigation to identify additional exposures. Educating traditional healers about
rabies, the importance of PEP, and legal ramifications of rabies treatment by traditional
healers might prevent additional cases through proper medical treatment. All six dogs
associated with these cases were unvaccinated or had an unknown vaccination history,
suggesting a need for improvement in the canine rabies vaccination programs in Vietnam.
Although PEP is viewed favorably by the general population in Vietnam, these findings
suggest that some community members lack knowledge about its safety and appropriateness
for pregnant and breastfeeding women. Given that rabies is almost always fatal in
unvaccinated persons, there is an urgent need for public health messaging about the
safety and effectiveness of PEP, including for pregnant and breastfeeding women.
Summary
What is already known about this topic?
Human rabies deaths are preventable through prompt administration of postexposure
prophylaxis (PEP) with rabies immune globulin and rabies vaccine after exposure to
rabid animals. Rabies PEP is safe for use among pregnant and breastfeeding women;
studies have found no increased risk for spontaneous abortions, premature births,
or fetal abnormalities among pregnant women after receiving PEP.
What is added by this report?
During 2015–2016, six probable cases of rabies were reported among pregnant and breastfeeding
women in Vietnam. None of the six patients sought PEP after exposure. In each case,
families reported the patients’ fear of risk to the fetus or breastfed child as the
primary barrier to the women receiving PEP.
What are the implications for public health practice?
One strategy aimed at improving health care–seeking behavior and PEP acceptance is
training village health workers to educate community members, including pregnant and
breastfeeding women, regarding treatment options for rabies and the safety of PEP.
As more countries expand access to PEP, special attention should focus on addressing
vaccine hesitancy, particularly among pregnant and breastfeeding women, and improving
education of community health workers.