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Cognitive prognosis of patients with tuberous sclerosis complex.

Author(s): M B Pulsifer, E Winterkorn, Elizabeth Thiele

Publication date: 2007

Keywords: Adolescent, Adult, Child, Child, Preschool, Cognition Disorders, complications, diagnosis, genetics, Female, Humans, Infant, Infant, Newborn, Male, Middle Aged, Mutation, Prognosis, Retrospective Studies, Tuberous Sclerosis

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Abstract

To assess cognitive outcome in patients with tuberous sclerosis complex (TSC) and identify predictive risk factors, we reviewed records of 107 patients who underwent comprehensive neuropsychiatric evaluation. Fifty-seven percent of patients with TSC had normal-range IQ/developmental quotient (DQ). Cognitive outcome was strongly associated with refractory seizures and TSC2 mutation. In TSC, IQ/DQ is bimodally distributed, and more than half of individuals are in the normal range.

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PubMed ID:: 17200495

DOI:: 10.1212/01.wnl.0000250330.44291.54

ScienceOpen disciplines: Chemistry

Keywords: Adolescent,Adult,Child,Child, Preschool,Cognition Disorders,complications,diagnosis,genetics,Female,Humans,Infant,Infant, Newborn,Male,Middle Aged,Mutation,Prognosis,Retrospective Studies,Tuberous Sclerosis

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ScienceOpen disciplines: Chemistry

Cognitive prognosis of patients with tuberous sclerosis complex.

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