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      Immune-related gene expression signatures: a step forward in the stratification of patients with ovarian clear cell carcinoma†.

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          Abstract

          Clear cell carcinoma of the ovary (CCC) is one of the five major histological types of ovarian cancer and presents specific clinicopathological features, such as a higher prevalence in the Asian population and a poor response to conventional chemotherapy. In a recent publication in The Journal of Pathology, Heong, Tan, Miwa et al demonstrated the heterogeneity of the immune landscape of CCC. They reported the immune signatures observed in a large cohort of CCC, including tumours from both Asian and Caucasian women. The authors analysed three cohorts from Europe, Japan, and Singapore, with a total of 246 tumours, and evaluated 730 immune-related genes using NanoString technology. The study revealed four main transcriptional subtypes characterised by the expression of specific sets of genes: PD1-high (11%), CTLA4-high (29%), antigen-presentation (42%), and a pro-angiogenic subtype (18%). The two main conclusions of the study were: (1) that CCCs in women of Asian and Caucasian descent share significant molecular similarities, since all four molecular signatures are present in all the cohorts analysed, without any evident differences in frequency; and (2) that the PD1-high and CTLA4-high subtypes were associated with worse clinical outcomes and may be useful when stratifying treatment in early-stage tumours. The immune signature could represent a promising biomarker of immunotherapy response if future prospective studies confirm it. © 2021 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.

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          Author and article information

          Journal
          J Pathol
          The Journal of pathology
          Wiley
          1096-9896
          0022-3417
          Apr 2022
          : 256
          : 4
          Affiliations
          [1 ] Pathology Department, Hospital Universitario Ramón y Cajal, IRYCIS, Madrid, Spain.
          [2 ] Faculty of Medicine, Universidad de Alcalá, Alcalá de Henares, Spain.
          [3 ] CIBERONC, Madrid, Spain.
          Article
          10.1002/path.5850
          34908168
          949c5c26-51a7-45ba-b1e4-9bf2a5a91076
          History

          immunotherapy,immune signature,clear cell carcinoma of the ovary,biomarker

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