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      Microorganisms under extreme environments and their applications

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          Abstract

          Extremophiles are group of microorganisms that possess ability to tolerate and live under the extremes of physico-chemical, geological and nutritional conditions. Such microorganisms are evolutionary relics and have evolved adaptation strategies at cellular, biochemical and molecular levels. They produce enzymes that are capable to maintain stability and function under the multitudes of extremities. These organisms also produce variety of other molecules and metabolites, such as extremolytes and surface-active compounds to protect against extremes of salinity, pH, pressure, temperatures and solar radiation. Investigations on these microorganisms can further open new avenues and opportunity for research and biotechnological applications in the areas of waste water treatment, bio-plastics, biofuel, cosmetics, agriculture, food and pharmaceuticals. Further, extremophiles have potential roles to play in bioremediation, astrobiology and biorefinery.

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          Most cited references13

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          Metabolic Kinases Moonlighting as Protein Kinases

          Protein kinases regulate every aspect of cellular activity, whereas metabolic enzymes are responsible for energy production and catabolic and anabolic processes. Emerging evidence demonstrates that some metabolic enzymes, such as pyruvate kinase M2, phosphoglycerate kinase 1, ketohexokinase isoform A, hexokinase (HK), and nucleoside diphosphate kinase 1 and 2 (NME1/2), that phosphorylate soluble metabolites can also function as protein kinases and phosphorylate a variety of protein substrates to regulate the Warburg effect, gene expression, cell cycle progression and proliferation, apoptosis, autophagy, exosome secretion, T-cell activation, iron transport, ion channel opening, and many other fundamental cellular functions. The elevated protein kinase functions of these moonlighting metabolic enzymes in tumor development make them promising therapeutic targets for cancer.
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            Biotechnological applications of extremophiles, extremozymes and extremolytes.

            In the last decade, attention to extreme environments has increased because of interests to isolate previously unknown extremophilic microorganisms in pure culture and to profile their metabolites. Microorganisms that live in extreme environments produce extremozymes and extremolytes that have the potential to be valuable resources for the development of a bio-based economy through their application to white, red, and grey biotechnologies. Here, we provide an overview of extremophile ecology, and we review the most recent applications of microbial extremophiles and the extremozymes and extremolytes they produce to biotechnology.
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              Differential effect of algal- and soil-derived dissolved organic matter on alpine lake bacterial community composition and activity

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                Author and article information

                Contributors
                Journal
                Curr Res Microb Sci
                Curr Res Microb Sci
                Current Research in Microbial Sciences
                Elsevier
                2666-5174
                28 May 2022
                2022
                28 May 2022
                : 3
                : 100141
                Affiliations
                [a ]Department of Microbiology, Sikkim University, 6th Mile, Tadong 737102, Gangtok, Sikkim, India
                [b ]UGC-CAS Department of Biosciences, Saurashtra University, Rajkot 360005, Gujarat, India
                [c ]Carl R. Woese Institute for Genomic Biology, University of Illinois Urbana-Champaign, Champaign, Illinois, United States
                Author notes
                [* ]Corresponding author. nthakur@ 123456cus.ac.in
                Article
                S2666-5174(22)00038-4 100141
                10.1016/j.crmicr.2022.100141
                9325898
                35909627
                943ebe82-ef17-443b-8bd0-bdb99418b31d
                © 2022 Published by Elsevier B.V.

                This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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                Articles from the special issue: Microorganisms of extreme environments and their applications, edited by Nagendra Thakur and Satya Singh

                extremophiles,halophiles,psychrophiles,application,enzyme
                extremophiles, halophiles, psychrophiles, application, enzyme

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