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      Current Trends of Bioactive Peptides—New Sources and Therapeutic Effect

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          Abstract

          Generally, bioactive peptides are natural compounds of food or part of protein that are inactive in the precursor molecule. However, they may be active after hydrolysis and can be transported to the active site. Biologically active peptides can also be synthesized chemically and characterized. Peptides have many properties, including antihypertensive, antioxidant, antimicrobial, anticoagulant, and chelating effects. They are also responsible for the taste of food or for the inhibition of enzymes involved in the development of diseases. The scientific literature has described many peptides with bioactive properties obtained from different sources. Information about the structure, origin, and properties of peptides can also be found in many databases. This review will describe peptides inhibiting the development of current diseases, peptides with antimicrobial properties, and new alternative sources of peptides based on the current knowledge and documentation of their bioactivity. All these issues are part of modern research on peptides and their use in current health or technological problems in food production.

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          Most cited references172

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          Antimicrobial Peptides

          The rapid increase in drug-resistant infections has presented a serious challenge to antimicrobial therapies. The failure of the most potent antibiotics to kill “superbugs” emphasizes the urgent need to develop other control agents. Here we review the history and new development of antimicrobial peptides (AMPs), a growing class of natural and synthetic peptides with a wide spectrum of targets including viruses, bacteria, fungi, and parasites. We summarize the major types of AMPs, their modes of action, and the common mechanisms of AMP resistance. In addition, we discuss the principles for designing effective AMPs and the potential of using AMPs to control biofilms (multicellular structures of bacteria embedded in extracellular matrixes) and persister cells (dormant phenotypic variants of bacterial cells that are highly tolerant to antibiotics).
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            Foodborne pathogens

            Foodborne pathogens are causing a great number of diseases with significant effects on human health and economy. The characteristics of the most common pathogenic bacteria (Bacillus cereus, Campylobacter jejuni, Clostridium botulinum, Clostridium perfringens, Cronobacter sakazakii, Esherichia coli, Listeria monocytogenes, Salmonella spp., Shigella spp., Staphylococccus aureus, Vibrio spp. and Yersinia enterocolitica), viruses (Hepatitis A and Noroviruses) and parasites (Cyclospora cayetanensis, Toxoplasma gondii and Trichinella spiralis), together with some important outbreaks, are reviewed. Food safety management systems based on to classical hazard-based approach has been proved to be inefficient, and risk-based food safety approach is now suggested from leading researchers and organizations. In this context, a food safety management system should be designed in a way to estimate the risks to human health from food consumption and to identify, select and implement mitigation strategies in order to control and reduce these risks. In addition, the application of suitable food safety education programs for all involved people in the production and consumption of foods is suggested.
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              Antioxidant peptides from marine by-products: Isolation, identification and application in food systems. A review

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                Author and article information

                Journal
                Foods
                Foods
                foods
                Foods
                MDPI
                2304-8158
                29 June 2020
                July 2020
                : 9
                : 7
                : 846
                Affiliations
                [1 ]Department of Biochemistry and Food Chemistry, University of Life Sciences in Lublin, 20-704 Lublin, Poland; monika.karas@ 123456up.lublin.pl
                [2 ]Department of Environmental Microbiology, University of Life Sciences in Lublin, 20-069 Lublin, Poland; kamila.rybczynska-tkaczyk@ 123456up.lublin.pl
                [3 ]Department of Analysis and Evaluation of Food Quality, University of Life Sciences in Lublin, 20-704 Lublin, Poland; ewelina.zielinska@ 123456up.lublin.pl
                [4 ]Department of Animal Ethology and Wildlife Management, University of Life Sciences in Lublin, 20-950 Lublin, Poland; damian.zielinski@ 123456up.lublin.pl
                Author notes
                [* ]Correspondence: anna.jakubczyk@ 123456up.lublin.pl ; Tel.: +48-81-462-33-96
                Author information
                https://orcid.org/0000-0002-1087-2000
                https://orcid.org/0000-0002-6082-3864
                https://orcid.org/0000-0002-2100-1315
                https://orcid.org/0000-0002-9131-2688
                Article
                foods-09-00846
                10.3390/foods9070846
                7404774
                32610520
                943436ae-766e-4f34-ae88-81c0ef4c1cc1
                © 2020 by the authors.

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/).

                History
                : 26 May 2020
                : 22 June 2020
                Categories
                Review

                bioactive peptides,antioxidant,metabolic syndrome,peptide inhibitors,antimicrobial peptides,peptides from edible insects

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