Resultados da aplicação tópica do extrato de própolis na redução da progressão da doença periodontal

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Abstract

RESUMO Agentes químicos têm sido usados para auxiliar na inibição da formação do biofilme e impedir desenvolvimento da doença periodontal (DP). O objetivo deste estudo foi avaliar radiograficamente a ação do extrato de própolis na progressão da DP induzida em ratos. Foram utilizados 48 ratos Wistar, divididos em 4 grupos (n=12): Controle, Pincel, Própolis e Clorexidina. Os grupos foram subdivididos para análise aos 7 e 21 dias. A progressão da DP foi avaliada radiograficamente pela distância entre a junção cemento-esmalte e a crista óssea alveolar na face mesial do 1º molar inferior. A perda óssea foi significativamente menor nos animais do grupo própolis em ambos os períodos (p ≤ 0,01). Concluiu-se por análise radiográfica que a aplicação tópica do extrato de própolis interfere reduzindo a progressão da doença periodontal induzida por ligadura em ratos, demonstrando a importância desse composto como substância auxiliar no tratamento periodontal.

Translated abstract

ABSTRACT Chemical agents have been used to assist on inhibiting biofilm formation and on preventing the development of periodontal disease (PD). The aim of this study was to radiographically evaluate the action of propolis extract on the progression of PD induced in rats. 48 Wistar rats were divided into 4 groups (n = 12): Control, Brush, Propolis and Chlorhexidine. The groups were subdivided for analysis at 7 and 21 days. The progression of the periodontal disease was radiographically assessed by the distance between the cement-enamel junction and the alveolar bone crest mesial of the 1st molar. Bone loss was significantly lower in the Propolis group in both periods (p ≤ 0.01). By radiographic analysis, it is concluded that the topical application of propolis extract interferes by reducing the progression of ligature-induced periodontal disease in rats, demonstrating the importance of this compound as an auxiliary substance in periodontal treatment.

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Most cited references 46

Record: found
Abstract: found
Article: not found

The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer.

E. Middleton, C. Kandaswami, T Theoharides (2000)

Flavonoids are nearly ubiquitous in plants and are recognized as the pigments responsible for the colors of leaves, especially in autumn. They are rich in seeds, citrus fruits, olive oil, tea, and red wine. They are low molecular weight compounds composed of a three-ring structure with various substitutions. This basic structure is shared by tocopherols (vitamin E). Flavonoids can be subdivided according to the presence of an oxy group at position 4, a double bond between carbon atoms 2 and 3, or a hydroxyl group in position 3 of the C (middle) ring. These characteristics appear to also be required for best activity, especially antioxidant and antiproliferative, in the systems studied. The particular hydroxylation pattern of the B ring of the flavonoles increases their activities, especially in inhibition of mast cell secretion. Certain plants and spices containing flavonoids have been used for thousands of years in traditional Eastern medicine. In spite of the voluminous literature available, however, Western medicine has not yet used flavonoids therapeutically, even though their safety record is exceptional. Suggestions are made where such possibilities may be worth pursuing.

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Record: found
Abstract: found
Article: not found

Flavonoids as anti-inflammatory agents: implications in cancer and cardiovascular disease.

Ana García-Lafuente, Eva Guillamón, Ana Villares … (2009)

Chronic inflammation is being shown to be increasingly involved in the onset and development of several pathological disturbances such as arteriosclerosis, obesity, diabetes, neurodegenerative diseases and even cancer. Treatment for chronic inflammatory disorders has not been solved, and there is an urgent need to find new and safe anti-inflammatory compounds. Flavonoids belong to a group of natural substances occurring normally in the diet that exhibit a variety of beneficial effects on health. The anti-inflammatory properties of flavonoids have been studied recently, in order to establish and characterize their potential utility as therapeutic agents in the treatment of inflammatory diseases. Several mechanisms of action have been proposed to explain in vivo flavonoid anti-inflammatory actions, such as antioxidant activity, inhibition of eicosanoid generating enzymes or the modulation of the production of proinflammatory molecules. Recent studies have also shown that some flavonoids are modulators of proinflammatory gene expression, thus leading to the attenuation of the inflammatory response. However, much work remains to be done in order to achieve definitive conclusions about their potential usefulness. This review summarizes the known mechanisms involved in the anti-inflammatory activity of flavonoids and the implications of these effects on the protection against cancer and cardiovascular disease.

0 comments Cited 231 times – based on 0 reviews      Review now

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Record: found
Abstract: not found
Article: not found

The pathogenesis of human periodontitis: an introduction.

R C Page, K Kornman (1997)

0 comments Cited 226 times – based on 0 reviews      Review now

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Author and article information

Contributors

M.R.G. RIBEIRO: Role: ND

A.M. GUALBERTO: Role: ND

M.A.S. SILVA: Role: ND

S.F.C. SOUZA: Role: ND

E.M. SOUZA: Role: ND

V.C. SILVA: Role: ND

Journal

Journal ID (publisher): rbpm

Title: Revista Brasileira de Plantas Medicinais

Abbreviated Title: Rev. bras. plantas med.

Publisher: Sociedade Brasileira de Plantas Medicinais (Botucatu )

ISSN: 1983-084X

Publication date (Print): 2015

Volume: 17

Issue: 4 suppl 2

Pages: 915-921

Affiliations

[1 ] Universidade Federal do Maranhão Brazil

[2 ] Centro Universitário do Maranhão Brazil

Article

Publisher ID: S1516-05722015000600915

DOI: 10.1590/1983-084X/14_136

SO-VID: 938925f3-2d51-4e2b-a3b9-1596826c340c

License:

http://creativecommons.org/licenses/by/4.0/

History

Product

SciELO Brazil

Self URI (journal page): http://www.scielo.br/scielo.php?script=sci_serial&pid=1516-0572&lng=en

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