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Challenging SNP impact on caspofungin resistance by full-length FKS1 allele replacement in Candida lusitaniae.
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Abstract
A strain of the opportunistic pathogenic yeast Candida lusitaniae was genetically engineered for full-length replacement of the FKS1 gene encoding the target of echinocandin antifungals in order to assess the impact of FKS mutations on echinocandin resistance and reduced echinocandin susceptibility (RES).