The COVID-19 pandemic which expeditiously turned into a global health crisis also triggered many risks and uncertainties especially for vulnerable groups such as migrants and refugees as a result of the measures restricting social, economic, and educational life as well as mobility. According to the relational sociological perspective, each uncertainty process creates various changes on social networks and relationships, and these relational changes also affect identities, roles, and relational strategies. With this study, it is aimed to explore the economic, social, and familial impacts of the COVID-19 lockdown on Syrian migrants’ lives in Turkey from a relational sociological perspective. The data in the study is obtained by semi-structured qualitative interviews with 13 Syrian citizens living in Mersin province of Turkey. According to the findings of the study, the suspension or slowdown of economic activities due to the pandemic has caused not only an uncertainty about the future, but also a change in familial positions and roles. Also the accepted norms of social relations have been inevitably suspended resulting in increased ambiguity. Strengthening the network of solidarity within relatives and building stronger relationships within the family are common relational strategies of the participants to mitigate the social and economic impacts of the COVID-19 outbreak, but these strategies will not be adequate if the lockdown process is prolonged. Considering the fact that the lockdown measures can be tightened again at any time, social and economic policies should be expanded to include the Syrian migrants in Turkey.