Commentary: IL-4 and IL-13 receptors and signaling.

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Abstract

Interleukin (IL)-4 and IL-13 were discovered approximately 30years ago and were immediately linked to allergy and atopic diseases. Since then, new roles for IL-4 and IL-13 and their receptors in normal gestation, fetal development and neurological function and in the pathogenesis of cancer and fibrosis have been appreciated. Studying IL-4/-13 and their receptors has revealed important clues about cytokine biology and led to the development of numerous experimental therapeutics. Here we aim to highlight new discoveries and consolidate concepts in the field of IL-4 and IL-13 structure, receptor regulation, signaling and experimental therapeutics.

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Author and article information

Journal

Journal ID (iso-abbrev): Cytokine

Title: Cytokine

Publisher: Elsevier BV

ISSN (Electronic): 1096-0023

ISSN (Print): 1043-4666

Publication date (Electronic): Sep 2015

Volume: 75

Issue: 1

Affiliations

[1 ] Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, United States.

[2 ] Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, United States; Division of Allergy and Clinical Immunology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, United States. Electronic address: nheller@jhmi.edu.

Article

Publisher Item ID: S1043-4666(15)00209-4 Mid ID: NIHMS709321

DOI: 10.1016/j.cyto.2015.05.023

PMC ID: 4546937

PubMed ID: 26187331

SO-VID: 92e131f7-b232-4c29-8f36-ce85386eb329

History

Keywords: Interleukin-13,Interleukin-4,Receptor,Regulation,Singling

Data availability:

Keywords: Interleukin-13, Interleukin-4, Receptor, Regulation, Singling

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