6
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Numerical computation of pulsatile hemodynamics and diagnostic concern of coronary bifurcated artery flow for Newtonian and non-Newtonian fluid

      research-article

      Read this article at

      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Atherosclerotic with the high occurrence of plaque formation due to stenosis has attracted wide attention among researchers. The left coronary artery has been studied in two-dimensional and in three-dimensional (3D) bifurcation as the models of blood flow through Newtonian and non-Newtonian fluids to better understand the physical mechanism. The computational Fluid Dynamics (CFD) technique is incorporated in COMSOL Multiphysics and then it is justified by satisfactory validation. It is found that the Newtonian model shows larger recirculation zones than non-Newtonian does. The present study also focuses on the evaluations of the lesion of diagnostic and the coefficient of pressure drop assessments on the basis of the diagnostic parameter’s critical values affected by the rheological model. Nevertheless, the leading concentration of the subsisting investigation works is confined to the change of importance factor ( IFc ) affected by arterial blockage. But the IFc of non-Newtonian fluid for 3D left coronary artery bifurcation model decreases with increasing bifurcation angle and the time-averaged inlet pressure is the least for smaller bifurcation angles. The current research further concentrates that the flow separation length reduces with developing bifurcation angle in bifurcated geometry. It is significant to mention that non-Newtonian blood flow model incorporating hemodynamic and diagnostic parameters has great impacts on instantaneous flow systems.

          Related collections

          Most cited references34

          • Record: found
          • Abstract: found
          • Article: not found

          Non-Newtonian blood flow in human right coronary arteries: steady state simulations.

          This study looks at blood flow through four different right coronary arteries, which have been reconstructed from bi-plane angiograms. Five non-Newtonian blood models, as well as the usual Newtonian model of blood viscosity, are used to study the wall shear stress in each of these arteries at a particular point in the cardiac cycle. It was found that in the case of steady flow in a given artery, the pattern of wall shear stress is consistent across all models. The magnitude of wall shear stress, however, is influenced by the model used and correlates with graphs of shear stress versus strain for each model. For mid-range velocities of around 0.2 m s(-1) the models are virtually indistinguishable. Local and global non-Newtonian importance factors are introduced, in an attempt to quantify the types of flows where non-Newtonian behaviour is significant. It is concluded that, while the Newtonian model of blood viscosity is a good approximation in regions of mid-range to high shear, it is advisable to use the Generalised Power Law model (which tends to the Newtonian model in those shear ranges in any case) in order to achieve better approximation of wall shear stress at low shear.
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Pulsatile flow in the human left coronary artery bifurcation: average conditions.

            Xiaoyi He (1996)
            The localization of atherosclerosis in the coronary arteries may be governed by local hemodynamic features. In this study, the pulsatile hemodynamics of the left coronary artery bifurcation was numerically simulated using the spectral element method for realistic in vivo anatomic and physiologic conditions. The velocity profiles were found to be skewed in both the left anterior descending and the circumflex coronary arteries. Velocity skewing arose from the bifurcation as well as from the curvature of the artery over the myocardial surface. Arterial wall shear stress was significantly lower in the bifurcation region, including the side walls. The greatest oscillatory behavior was localized to the outer wall of the circumflex artery. The time-averaged mean wall shear stress varied from about 3 to 98 dynes/cm2 in the left coronary artery system. The highly localized distribution of low and oscillatory shear stress along the walls strongly correlates with the focal locations of atheroma in the human left coronary artery.
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Spatial comparison between wall shear stress measures and porcine arterial endothelial permeability.

              A better understanding of how hemodynamic factors affect the integrity and function of the vascular endothelium is necessary to appreciate more fully how atherosclerosis is initiated and promoted. A novel technique is presented to assess the relation between fluid dynamic variables and the permeability of the endothelium to macromolecules. Fully anesthetized, domestic swine were intravenously injected with the albumin marker Evans blue dye, which was allowed to circulate for 90 min. After the animals were euthanized, silicone casts were made of the abdominal aorta and its iliac branches. Pulsatile flow calculations were subsequently made in computational regions derived from the casts. The distribution of the calculated time-dependent wall shear stress in the external iliac branches was directly compared on a point-by-point basis with the spatially varying in vivo uptake of Evans blue dye in the same arteries. The results indicate that in vivo endothelial permeability to albumin decreases with increasing time-average shear stress over the normal range. Additionally, endothelial permeability increases slightly with oscillatory shear index.
                Bookmark

                Author and article information

                Contributors
                Journal
                Heliyon
                Heliyon
                Heliyon
                Elsevier
                2405-8440
                03 July 2023
                July 2023
                03 July 2023
                : 9
                : 7
                : e17533
                Affiliations
                [a ]Department of Applied Mathematics, University of Dhaka, Dhaka-1000, Bangladesh
                [b ]Research Group of Fluid Flow Modeling and Simulation, Department of Applied Mathematics, University of Dhaka, Dhaka-1000, Bangladesh
                [c ]Department of Applied Mathematics, Noakhali Science and Technology University, Noakhali-3814, Bangladesh
                Author notes
                []Corresponding author. Department of Applied Mathematics, University of Dhaka, Dhaka-1000, Bangladesh zavid@ 123456du.ac.bd
                Article
                S2405-8440(23)04741-2 e17533
                10.1016/j.heliyon.2023.e17533
                10344714
                926ff8e7-b845-4d8e-a218-cf0e83b15c75
                © 2023 The Authors. Published by Elsevier Ltd.

                This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

                History
                : 26 January 2023
                : 31 May 2023
                : 20 June 2023
                Categories
                Research Article

                cfd,pulsatile flow,pressure drop,recirculation length,lesion flow coefficient,importance factor(ifc)

                Comments

                Comment on this article