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      Oncometabolite Accumulation and Epithelial-to-Mesenchymal Transition: The Turn of Fumarate.

      1 , 2
      Cell metabolism
      Elsevier BV

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          Abstract

          Mutations to the Krebs cycle enzyme fumarate hydratase in cancer cells leads to an accumulation of the oncometabolite fumarate. Sciacovelli et al. (2016) demonstrate an epigenetically dependent epithelial-to-mesenchymal transition mediated by modulation of the miR-200 cluster and TET demethylation in response to fumarate accumulation.

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          Author and article information

          Journal
          Cell Metab.
          Cell metabolism
          Elsevier BV
          1932-7420
          1550-4131
          October 11 2016
          : 24
          : 4
          Affiliations
          [1 ] Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), 08908 L'Hospitalet de Llobregat, Barcelona, Catalonia, Spain.
          [2 ] Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), 08908 L'Hospitalet de Llobregat, Barcelona, Catalonia, Spain; Institució Catalana de Recerca i Estudis Avançats (ICREA), 08010 Barcelona, Catalonia, Spain; Department of Physiological Sciences II, School of Medicine, University of Barcelona, 08036 Barcelona, Catalonia, Spain. Electronic address: mesteller@idibell.cat.
          Article
          S1550-4131(16)30505-8
          10.1016/j.cmet.2016.09.020
          27732835
          92497b7b-3f41-4310-828e-dba411ebff1d
          History

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