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      Endometrial cancer arising from adenomyosis with unusual manifestation: A case report

      case-report

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          Key Clinical Message

          Endometrial Carcinoma Arising from Adenomyosis (EC‐AIA) is an unusual condition, primarily occurring in postmenopausal women. We present a rare case of a 34‐year‐old woman with EC‐AIA, highlighting the diagnostic challenges in distinguishing this malignancy from adenomyosis preoperatively. Conventional imaging methods exhibited limitations, necessitating post‐surgery confirmation through comprehensive examinations. The case emphasizes the need for a multidisciplinary approach for accurate diagnosis and timely management in such uncommon gynecological conditions.

          Abstract

          Histological images depict the rarity of Endometrial Carcinoma Arising from Adenomyosis (EC‐AIA) in a 34‐year‐old premenopausal woman. Sections reveal tumoral nests beneath the myometrial layer with distinctive glandular architectures. Diagnostic challenges necessitate post‐surgery confirmation, emphasizing the need for a multidisciplinary approach for accurate diagnosis and timely management in uncommon gynecological conditions.

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          Most cited references16

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          Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

          This article provides an update on the global cancer burden using the GLOBOCAN 2020 estimates of cancer incidence and mortality produced by the International Agency for Research on Cancer. Worldwide, an estimated 19.3 million new cancer cases (18.1 million excluding nonmelanoma skin cancer) and almost 10.0 million cancer deaths (9.9 million excluding nonmelanoma skin cancer) occurred in 2020. Female breast cancer has surpassed lung cancer as the most commonly diagnosed cancer, with an estimated 2.3 million new cases (11.7%), followed by lung (11.4%), colorectal (10.0 %), prostate (7.3%), and stomach (5.6%) cancers. Lung cancer remained the leading cause of cancer death, with an estimated 1.8 million deaths (18%), followed by colorectal (9.4%), liver (8.3%), stomach (7.7%), and female breast (6.9%) cancers. Overall incidence was from 2-fold to 3-fold higher in transitioned versus transitioning countries for both sexes, whereas mortality varied <2-fold for men and little for women. Death rates for female breast and cervical cancers, however, were considerably higher in transitioning versus transitioned countries (15.0 vs 12.8 per 100,000 and 12.4 vs 5.2 per 100,000, respectively). The global cancer burden is expected to be 28.4 million cases in 2040, a 47% rise from 2020, with a larger increase in transitioning (64% to 95%) versus transitioned (32% to 56%) countries due to demographic changes, although this may be further exacerbated by increasing risk factors associated with globalization and a growing economy. Efforts to build a sustainable infrastructure for the dissemination of cancer prevention measures and provision of cancer care in transitioning countries is critical for global cancer control.
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            Risk factors for endometrial cancer: An umbrella review of the literature

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              Endometrial cancer.

              Although endometrial cancer management remains challenging, a deeper understanding of the genetic diversity as well as the drivers of the various pathogenic states of this disease has led to development of divergent management approaches in an effort to improve therapeutic precision in this complex malignancy. This comprehensive review provides an update on the epidemiology, pathophysiology, diagnosis and molecular classification, recent advancements in disease management, as well as important patient quality-of-life considerations and emerging developments in the rapidly evolving therapeutic landscape of endometrial cancers.
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                Author and article information

                Contributors
                karaji.sina@gmail.com
                Journal
                Clin Case Rep
                Clin Case Rep
                10.1002/(ISSN)2050-0904
                CCR3
                Clinical Case Reports
                John Wiley and Sons Inc. (Hoboken )
                2050-0904
                27 December 2023
                January 2024
                : 12
                : 1 ( doiID: 10.1002/ccr3.v12.1 )
                : e8353
                Affiliations
                [ 1 ] Fellowship in Obstetrics & GYN Imaging, Firoozabadi Clinical Research Development Unit (FACRDU), Department of Radiology, School of Medicine Iran University of Medical Sciences Tehran Iran
                [ 2 ] Department of Radiology Hamedan University of Medical Sciences Hamedan Iran
                [ 3 ] Department of Radiology Iran University of Medical Sciences Tehran Iran
                [ 4 ] Department of Pathology, School of Medicine Iran University of Medical Science Tehran Iran
                [ 5 ] Department of Radiology, School of Medicine, Rasool Akram hospital Iran university of medical sciences Tehran Iran
                [ 6 ] Department of Radiology Tehran University of Medical Sciences Tehran Iran
                Author notes
                [*] [* ] Correspondence

                Sina Karaji, Department of Radiology, Iran University of Medical Sciences, Tehran, Iran.

                Email: karaji.sina@ 123456gmail.com

                Author information
                https://orcid.org/0000-0001-6563-7035
                https://orcid.org/0000-0002-0432-9407
                https://orcid.org/0000-0003-2732-7858
                https://orcid.org/0000-0002-0378-3085
                Article
                CCR38353 CCR3-2023-08-1611.R1
                10.1002/ccr3.8353
                10753132
                38161634
                923c0933-b5ef-45a7-81b4-f88f0c4fbeb1
                © 2023 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd.

                This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

                History
                : 16 November 2023
                : 04 August 2023
                : 02 December 2023
                Page count
                Figures: 4, Tables: 0, Pages: 5, Words: 2794
                Categories
                Radiology & Imaging
                Toxicology
                Psychiatry
                Oncology
                Case Report
                Case Report
                Custom metadata
                2.0
                January 2024
                Converter:WILEY_ML3GV2_TO_JATSPMC version:6.3.6 mode:remove_FC converted:28.12.2023

                adenomyosis,endometrial cancer,mri,ultrasonography,uterine cancer

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