Neuropharmacological Effects of Quercetin: A Literature-Based Review

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

Quercetin (QUR) is a natural bioactive flavonoid that has been lately very studied for its beneficial properties in many pathologies. Its neuroprotective effects have been demonstrated in many in vitro studies, as well as in vivo animal experiments and human trials. QUR protects the organism against neurotoxic chemicals and also can prevent the evolution and development of neuronal injury and neurodegeneration. The present work aimed to summarize the literature about the neuroprotective effect of QUR using known database sources. Besides, this review focuses on the assessment of the potential utilization of QUR as a complementary or alternative medicine for preventing and treating neurodegenerative diseases. An up-to-date search was conducted in PubMed, Science Direct and Google Scholar for published work dealing with the neuroprotective effects of QUR against neurotoxic chemicals or in neuronal injury, and in the treatment of neurodegenerative diseases. Findings suggest that QUR possess neuropharmacological protective effects in neurodegenerative brain disorders such as Alzheimer’s disease, Amyloid β peptide, Parkinson’s disease, Huntington's disease, multiple sclerosis, and amyotrophic lateral sclerosis. In summary, this review emphasizes the neuroprotective effects of QUR and its advantages in being used in complementary medicine for the prevention and treatment o of different neurodegenerative diseases.

Related collections

Most cited references 205

Record: found
Abstract: found
Article: not found

Neuroinflammation in Alzheimer's disease.

Michael T Heneka, Monica Carson, Joseph El Khoury … (2015)

Increasing evidence suggests that Alzheimer's disease pathogenesis is not restricted to the neuronal compartment, but includes strong interactions with immunological mechanisms in the brain. Misfolded and aggregated proteins bind to pattern recognition receptors on microglia and astroglia, and trigger an innate immune response characterised by release of inflammatory mediators, which contribute to disease progression and severity. Genome-wide analysis suggests that several genes that increase the risk for sporadic Alzheimer's disease encode factors that regulate glial clearance of misfolded proteins and the inflammatory reaction. External factors, including systemic inflammation and obesity, are likely to interfere with immunological processes of the brain and further promote disease progression. Modulation of risk factors and targeting of these immune mechanisms could lead to future therapeutic or preventive strategies for Alzheimer's disease. Copyright © 2015 Elsevier Ltd. All rights reserved.

0 comments Cited 1411 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: not found

The Microglial Sensome Revealed by Direct RNA Sequencing

Suzanne E Hickman, Nathan D. Kingery, Toshiro K Ohsumi … (2013)

Microglia, the principal neuroimmune sentinels of the brain, continuously sense changes in their environment and respond to invading pathogens, toxins and cellular debris. Microglia exhibit plasticity and can assume neurotoxic or neuroprotective priming states that determine their responses to danger. We used direct RNA sequencing, without amplification or cDNA synthesis, to determine the quantitative transcriptomes of microglia of healthy adult and aged mice. We validated our findings by fluorescent dual in-situ hybridization, unbiased proteomic analysis and quantitative PCR. We report here that microglia have a distinct transcriptomic signature and express a unique cluster of transcripts encoding proteins for sensing endogenous ligands and microbes that we term the “sensome”. With aging, sensome transcripts for endogenous ligand recognition are downregulated, whereas those involved in microbe recognition and host defense are upregulated. In addition, aging is associated with an overall increase in expression of microglial genes involved in neuroprotection.

0 comments Cited 644 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: not found

Mechanisms underlying inflammation in neurodegeneration.

Christopher K. Glass, Kaoru Saijo, Beate Winner … (2010)

Inflammation is associated with many neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and multiple sclerosis. In this Review, we discuss inducers, sensors, transducers, and effectors of neuroinflammation that contribute to neuronal dysfunction and death. Although inducers of inflammation may be generated in a disease-specific manner, there is evidence for a remarkable convergence in the mechanisms responsible for the sensing, transduction, and amplification of inflammatory processes that result in the production of neurotoxic mediators. A major unanswered question is whether pharmacological inhibition of inflammation pathways will be able to safely reverse or slow the course of disease. 2010 Elsevier Inc. All rights reserved.

0 comments Cited 528 times – based on 0 reviews      Review now

Bookmark

All references

Author and article information

Contributors

Cristina Quispe: URI : https://loop.frontiersin.org/people/1069762/overview

Rajib Hossain: URI : https://loop.frontiersin.org/people/1225696/overview

Muhammad Torequl Islam: URI : https://loop.frontiersin.org/people/1164163/overview

Ahmed Al-Harrasi: URI : https://loop.frontiersin.org/people/435079/overview

Ahmed Al-Rawahi: URI : https://loop.frontiersin.org/people/855228/overview

Miquel Martorell: URI : https://loop.frontiersin.org/people/990095/overview

Ainur Seilkhan: URI : https://loop.frontiersin.org/people/1165829/overview

Anca Oana Docea: URI : https://loop.frontiersin.org/people/1056189/overview

Daniela Calina: URI : https://loop.frontiersin.org/people/430074/overview

Javad Sharifi-Rad: URI : https://loop.frontiersin.org/people/160127/overview

Journal

Journal ID (nlm-ta): Front Pharmacol

Journal ID (iso-abbrev): Front Pharmacol

Journal ID (publisher-id): Front. Pharmacol.

Title: Frontiers in Pharmacology

Publisher: Frontiers Media S.A.

ISSN (Electronic): 1663-9812

Publication date (Electronic): 17 June 2021

Publication date Collection: 2021

Volume: 12

Electronic Location Identifier: 665031

Affiliations

[ ¹ ]Department of Pharmacy, Life Science Faculty, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj, Bangladesh

[ ² ]Facultad de Ciencias de La Salud, Universidad Arturo Prat, Iquique, Chile

[ ³ ]Natural and Medical Sciences Research Centre, University of Nizwa, Nizwa, Oman

[ ⁴ ]Department of Nutrition and Dietetics, Faculty of Pharmacy, Centre for Healthy Living, University of Concepción, Concepción, Chile

[ ⁵ ]Department of Biodiversity of Bioresources, Al-Farabi Kazakh National University, Almaty, Kazakhstan

[ ⁶ ]Educational program, Geography, Environment and Service sector, Abai Kazakh National Pedagogical University, Kazakhstan, Almaty, Kazakhstan

[ ⁷ ]Biomedical Research Centre, Al-Farabi Kazakh National University, Almaty, Kazakhstan

[ ⁸ ]Department of Molecular Biology and Genetics, Al-Farabi Kazakh National University, Almaty, Kazakhstan

[ ⁹ ]Department of Toxicology, University of Medicine and Pharmacy of Craiova, Craiova, Romania

[ ¹⁰ ]Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, Craiova, Romania

[ ¹¹ ]Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Author notes

Edited by: Philippe De Deurwaerdere, Université de Bordeaux, France

Reviewed by: Karl Tsim, Hong Kong University of Science and Technology, China

Touqeer Ahmed, National University of Sciences & Technology, Pakistan

Abhijit Dey, Presidency University, India

*Correspondence: Muhammad Torequl Islam, muhammad.torequl.islam@ 123456tdtu.edu.vn ; Ahmed Al-Harrasi, aharrasi@ 123456unizwa.edu.om ; Daniela Calina, calinadaniela@ 123456gmail.com ; Javad Sharifi-Rad, javad.sharifirad@ 123456gmail.com

This article was submitted to Neuropharmacology, a section of the journal Frontiers in Pharmacology

Article

Publisher ID: 665031

DOI: 10.3389/fphar.2021.665031

PMC ID: 8248808

PubMed ID: 34220504

SO-VID: 91929153-415f-4cf3-b52d-c16c13013446

License:

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

Neuropharmacological Effects of Quercetin: A Literature-Based Review

Read this article at

Abstract

Related collections

Neuropharmacology and Therapy

Most cited references 205

Neuroinflammation in Alzheimer's disease.

The Microglial Sensome Revealed by Direct RNA Sequencing

Mechanisms underlying inflammation in neurodegeneration.

Author and article information

Contributors

Journal

Affiliations

Author notes

Article

History

Categories

Comments

Comment on this article

Similar content 376

Cited by 42

Most referenced authors 2,361