ZnCl ₂-promoted domino reaction of 2-hydroxybenzonitriles with ketones for synthesis of 1,3-benzoxazin-4-ones†

Abstract

A ZnCl ₂-promoted synthesis of 1,3-benzoxazin-4-one from 2-hydroxybenzonitriles and ketones was developed. This method displays facile access to a diverse range of substituted 1,3-benzoxazin-4-ones in good yields. This synthetic protocol has advantages: (i) easy availability of starting material; (ii) strong corrosive acid-free condition; (iii) high yield.

Abstract

A method for the synthesis of 1,3-benzoxazine-4-ketone was developed using 2-hydroxybenzonitriles and ketones as raw materials with the promotion of ZnCl ₂.