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      When foods become remedies in ancient Greece: The curious case of garlic and other substances

      research-article
      *
      Journal of Ethnopharmacology
      Elsevier Sequoia
      History, Food-drug continuum, Hippocratic corpus, Dietetics, Garlic, Silphium

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          Abstract

          Ethnopharmacological relevance

          The debate on the food-drug continuum could benefit from a historical dimension. This study aims at showing this through one case: the food-drug continuum in Greece in the fifth- and fourth-century BCE. I suggest that at the time the boundary between food and drug – and that between dietetics and pharmacology – was rather blurred.

          Materials and methods

          I study definitions of ‘food’ and ‘medicine’ in texts from the fifth- and fourth-century BCE: the Hippocratic texts, the botanical treatises of Theophrastus and the pseudo-Aristotelian Problems. To illustrate these abstract definitions, I focus on two substances: garlic and silphium.

          Results and discussion

          The Hippocratics were writing in a context of increased professionalization and masculinization of medicine, a context in which dietetics became the most prestigious branch of medicine, praised above pharmacology and surgery. While medicine was becoming more specialised, professionalised and masculine, it avoided becoming too conspicuously so. The Hippocratic authors sometimes noted that medical discoveries are serendipitous and can be made by anyone, whether medically trained or not. By doing so, they allowed themselves to integrate common knowledge and practice into their writings.

          Conclusion

          In the context of the professionalization of ancient medicine, the Hippocratic authors started to address the difference between food and medicine. They saw, however, some advantage in acknowledging the continuum between food and medicine. Scholars should avoid drawing too strict a boundary between ancient dietetics and pharmacology and should instead adopt a multi-disciplinary approach to the therapeutics of the Hippocratic texts.

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          Most cited references97

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          New Insights into Cardiac and Brain Sodium Channels Modulation by Beta Blockers

          Beta-adrenergic blocking agents known as beta blockers are widely used in clinical practice to treat several cardiovascular disorders such as hypertension and high blood pressure in general. They are also used as cardioprotective agents in post myocardial infarction, for the treatment of cardiac arrhythmias and were reported to be beneficial in treating migraine. Recently, they were shown to be efficacious in treating patients with several types of congenital long QT syndromes and in patient with catecholaminergic polymorphic ventricular tachycardia. They mainly act by antagonizing the effects of norepinephrine released from sympathetic nerve endings on beta adrenoceptors. A direct interaction with ion channels in addition to the beta blocking property is now becoming more and more accepted in the scientific community. Propranolol is the beta blocker prototype, it is commonly used as racemic mixture with equal concentrations of R-(+)- and S-(−)-enantiomers. Although, they have been classified as class II antiarrhythmic drugs by Vaughan Williams the molecular mechanisms by which they act is not fully elucidated. On the other hand, their beneficial effect in preventing migraine is not well understood. Earlier electrophysiological studies have reported the effects of propranolol on heart rate and conduction properties in frog auricular fibers, rat, and canine ventricular myocytes. Recent data have shown that beta blockers could modulate Nav1.5, the cardiac voltage-gated sodium channels, but the effect on the expressed brain sodium channels was not envisaged. In the paper by Wang et al., the authors studied the effect of propanol on heterologously expressed recombinant human cardiac (Nav1.5) and the three brain (Nav1.1, Nav1.2, and Nav1.3) sodium channels using whole-cell patch clamp recordings. Previous work from the author's group showed that racemic propranolol and R-(+)-propranolol block Nav1.5 channels (Wang et al., 2008). In this paper the authors extended their study to evaluate the molecular mechanism of the reported block. Both R-(+) and S-(−) propranolol block Nav1.5 sodium channels in tonic and phasic (use-dependent or frequency-dependent) manner with similar affinities. However, nadolol a non-selective beta blocker and metoprolol a selective beta 1 blocker did not induce any tonic or phasic block, suggesting that the sodium channel block property is not common to all beta blockers. More detailed biophysical studies from the authors revealed that that R-(+)-propranolol exhibits biophysical effects on Nav1.5 that are similar but not identical to lidocaine, the class 1 antiarrhythmic drug prototype. That R-(+)-propranolol acts as a typical local anesthetic and class 1 antiarrhythmics on sodium channels by interacting with specific residues in the DIV-S6 segment, including the phenylalanine-1760, known to play a central role in drug binding (Ragsdale et al., 1994) and therefore shares this property with established antiarrhythmic drugs. Finally, further detailed biophysical study from the authors showed that the brain sodium channels (Nav1.1, Nav1.2, and Nav1.3) exhibit less sensitivity to R-(+)-propranolol than the Nav1.5 channels. Since the phenylalanine-1760 is a conserved residue in all sodium channels, including brain sodium channels, studies to elucidate the basis of this reduced affinity at molecular level are warranted. These data reported by Wang et al., in this issue of Frontiers in Pharmacology of Ion Channel and Channelopathies, will pave the path toward a more understanding of the effect of beta blockers on sodium channels, a widely used class of drugs.
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            Continuity and change in the Mediterranean medical tradition: Ruta spp. (rutaceae) in Hippocratic medicine and present practices.

            Ruta is a genus of Rutaceae family. It features mainly shrubby plants, native to the Mediterranean region and present in traditional medicine of this region since Antiquity. The three most diffused species Ruta chalepensis L., Ruta graveolens L., and Ruta montana (L.) L., are morphologically poorly differentiated and were probably interchangeably used during Antiquity. Hippocratic and contemporary medical applications of the Ruta genus in the Mediterranean were compared to check if they result from a continuity of use from the ancient times to nowadays. Ruta spp. was mainly employed in medical preparations by Hippocratic physicians as an abortifacient and emmenagogue. In addition to gynaecological conditions, in several treatises of the Corpus HippocraticumRuta spp. were also recommended as a specific remedy against pulmonary diseases. Ruta spp. leaves and also roots and seeds, were administered for internal use by Hippocratic physicians after having been soaked in wine or mixed with honey or its derivatives. Contemporary traditional uses of Ruta spp. have been assessed in detail in the whole Mediterranean area. Nowadays, Ruta spp. is used to treat different conditions but, as a general rule, the external uses are preferred as the toxicity of the plant is widely acknowledged.
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              Ethnobotany and ethnopharmacology--interdisciplinary links with the historical sciences.

              In this paper we use three disparate examples to highlight the relevance of historical methods in the context of ethnobotany and ethnopharmacology. Unfortunately, in ethnopharmacology we have only very few examples where such historical depth is possible. On the other hand the first hand data available through ethnopharmacological research, may be of relevance for interpreting historical information. Three distinct methods were used successfully in the retrospective exploration of diachronic data. In order to gain an insight into historical developments in the use of plant species and evolution of pharmacopoeias we used a botanico-historical approach (Rosmarinus officinalis), one that combines linguistic and statistical methods (Popoluca/Mixe), and one that uses historical documentary evidence (Ch'orti). We hope that this methodological discussion encourages a wider use of such historical methods in ethnopharmacology and related areas of research.
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                Author and article information

                Contributors
                Journal
                J Ethnopharmacol
                J Ethnopharmacol
                Journal of Ethnopharmacology
                Elsevier Sequoia
                0378-8741
                1872-7573
                05 June 2015
                05 June 2015
                : 167
                : 30-37
                Affiliations
                [0005]School of History, Archaeology and Religion, Cardiff University, Colum Drive, Cardiff CF10 3EU, United Kingdom
                Author notes
                [* ]Correspondence address: School of History, Archaeology and Religion, John Percival Building, Cardiff University, Colum Drive, Cardiff CF10 3EU, United Kingdom. Tel.: +44 29 208 75631. TotelinLM@ 123456cardiff.ac.uk
                Article
                S0378-8741(14)00612-6
                10.1016/j.jep.2014.08.018
                4469375
                25173971
                912c2783-4e87-4417-b6a1-1ec8e2d56512
                © 2014 The Author

                This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/3.0/).

                History
                : 1 May 2014
                : 8 August 2014
                : 17 August 2014
                Categories
                Research Paper

                Pharmacology & Pharmaceutical medicine
                history,food-drug continuum,hippocratic corpus,dietetics,garlic,silphium

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