For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
70
views
10
references
 Top references
cited by
68
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      1
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: not found

      Outbreak of Leptospirosis after Flood, the Philippines, 2009

      brief-report

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          After a typhoon in September 2009, an outbreak of leptospirosis occurred in Metro Manila, the Philippines; 471 patients were hospitalized and 51 (10.8%) died. A hospital-based investigation found risk factors associated with fatal infection to be older age, hemoptysis, anuria, jaundice, and delayed treatment with antimicrobial drugs.

          Related collections

          Most cited references10

          • Record: found
          • Abstract: found
          • Article: not found

          Leptospirosis: a zoonotic disease of global importance

          Ajay R Bharti, Jarlath E. Nally, Jessica Ricaldi … (2004)
          In the past decade, leptospirosis has emerged as a globally important infectious disease. It occurs in urban environments of industrialised and developing countries, as well as in rural regions worldwide. Mortality remains significant, related both to delays in diagnosis due to lack of infrastructure and adequate clinical suspicion, and to other poorly understood reasons that may include inherent pathogenicity of some leptospiral strains or genetically determined host immunopathological responses. Pulmonary haemorrhage is recognised increasingly as a major, often lethal, manifestation of leptospirosis, the pathogenesis of which remains unclear. The completion of the genome sequence of Leptospira interrogans serovar lai, and other continuing leptospiral genome sequencing projects, promise to guide future work on the disease. Mainstays of treatment are still tetracyclines and beta-lactam/cephalosporins. No vaccine is available. Prevention is largely dependent on sanitation measures that may be difficult to implement, especially in developing countries.
          Article 0 comments Cited 397 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            The globalization of leptospirosis: worldwide incidence trends.

            Georgios Pappas, Photini Papadimitriou, Vasiliki Siozopoulou … (2008)
            Leptospirosis continues to be a significant zoonosis of the developing world. Globalization, in the context of international travel, particularly for recreational activities and military expeditions, has led to increased exposure of individuals from the developed world to the disease, as recent outbreaks show. We evaluated the trends in annual leptospirosis incidence for individual countries worldwide through reports from national and international organizations, the published medical literature on the subject, and web searches with the terms 'leptospirosis' and the individual country names. Inter-country variations in leptospirosis incidence, when relevant official data were available, were also analyzed. The Caribbean and Latin America, the Indian subcontinent, Southeast Asia, Oceania, and to a lesser extent Eastern Europe, are the most significant foci of the disease, including areas that are popular travel destinations. Leptospirosis is a re-emerging zoonosis of global importance and unique environmental and social correlations. Attempts at global co-ordination and recognition of the true burden of an infectious disease with significant mortality should be encouraged.
            Article 0 comments Cited 157 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: found
              Is Open Access

              Leptospirosis in the Asia Pacific region

              Ann Florence B. Victoriano, Lee Smythe, Nina Gloriani-Barzaga … (2009)
              Background Leptospirosis is a worldwide zoonotic infection that has been recognized for decades, but the problem of the disease has not been fully addressed, particularly in resource-poor, developing countries, where the major burden of the disease occurs. This paper presents an overview of the current situation of leptospirosis in the region. It describes the current trends in the epidemiology of leptospirosis, the existing surveillance systems, and presents the existing prevention and control programs in the Asia Pacific region. Methods Data on leptospirosis in each member country were sought from official national organizations, international public health organizations, online articles and the scientific literature. Papers were reviewed and relevant data were extracted. Results Leptospirosis is highly prevalent in the Asia Pacific region. Infections in developed countries arise mainly from occupational exposure, travel to endemic areas, recreational activities, or importation of domestic and wild animals, whereas outbreaks in developing countries are most frequently related to normal daily activities, over-crowding, poor sanitation and climatic conditions. Conclusion In the Asia Pacific region, predominantly in developing countries, leptospirosis is largely a water-borne disease. Unless interventions to minimize exposure are aggressively implemented, the current global climate change will further aggravate the extent of the disease problem. Although trends indicate successful control of leptospirosis in some areas, there is no clear evidence that the disease has decreased in the last decade. The efficiency of surveillance systems and data collection varies significantly among the countries and areas within the region, leading to incomplete information in some instances. Thus, an accurate reflection of the true burden of the disease remains unknown.
              Article 0 comments Cited 118 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Journal
                Journal ID (nlm-ta): Emerg Infect Dis
                Journal ID (publisher-id): EID
                Title: Emerging Infectious Diseases
                Publisher: Centers for Disease Control and Prevention
                ISSN (Print): 1080-6040
                ISSN (Electronic): 1080-6059
                Publication date (Print): January 2012
                Volume: 18
                Issue: 1
                Pages: 91-94
                Affiliations
                [1]San Lazaro Hospital, Manila, Republic of the Philippines (A.T. Amilasan, E. Salva, M.C.P. Belo, S. Marte, E.M. Dimaano, J.B. Villarama);
                [2]National Center for Global Health and Medicine, Tokyo, Japan (M. Ujiie);
                [3]Nagasaki University, Nagasaki, Japan (M. Ujiie, M. Suzuki, W.-P. Schmidt, K. Ariyoshi);
                [4]National Institute of Infectious Diseases, Tokyo (N. Koizumi);
                [5]Hokkaido University, Sapporo, Japan (K. Yoshimatsu)
                Author notes
                Address for correspondence: Motoi Suzuki, Department of Clinical Medicine, Institute of Tropical Medicine, Nagasaki University, Sakamoto 1-12-4, Nagasaki 852-8523, Japan; email: mosuzuki@ 123456nagasaki-u.ac.jp
                Article
                Publisher ID: 10-1892
                DOI: 10.3201/eid1801.101892
                PMC ID: 3310081
                PubMed ID: 22257492
                SO-VID: 90e90ddc-123b-4d78-b52f-86ab67a9ddc3
                History
                Categories
                Subject: Dispatch
                Subject: Dispatch

                ScienceOpen disciplines: Infectious disease & Microbiology
                Keywords: typhoon,the philippines,weil disease,metro manila,leptospira,bacteria,flood,outbreak,leptospirosis
                Data availability:
                ScienceOpen disciplines: Infectious disease & Microbiology
                Keywords: typhoon, the philippines, weil disease, metro manila, leptospira, bacteria, flood, outbreak, leptospirosis

                Comments

                Comment on this article